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Alkaloids

Dihydrocodeine

Also known as Rapacodin, Novicondin, Codhydrine

CAS 125-28-0Formula C18H23NO3Molar mass 301.39 g/molEC 204-732-3
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant, Serious health hazard Prohibited, not for trade
Why it is not for trade
Dihydrocodeine chemical structure, C18H23NO3, CAS 125-28-0
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
125-28-0
Formula
C18H23NO3
Molar mass
301.39 g/mol
EC number
204-732-3
HS code
293911
Category
Alkaloids

What is Dihydrocodeine?

Plain description, key identifiers and synonyms

Dihydrocodeine is a morphinane alkaloid.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(4R,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol
CAS number
125-28-0 CAS number cross-checked
EC number
204-732-3
Molecular formula
C18H23NO3
UNII
N9I9HDB855
InChIKey
RBOXVHNMENFORY-DNJOTXNNSA-N
InChI
InChI=1S/C18H23NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19/h3,6,11-13,17,20H,4-5,7-9H2,1-2H3/t11-,12+,13-,17-,18-/m0/s1
Canonical SMILES
COc1ccc2c3c1OC1C(O)CCC4C(C2)N(C)CCC341
Isomeric SMILES
CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)OC)O[C@H]3[C@H](CC4)O

Synonyms

  • Rapacodin
  • Novicondin
  • Codhydrine
  • Dehacodin
  • Hydrocodeine
  • 8,14-Dihydroneopine
  • Dihidrocodeina
  • Dihydroneopine
  • Cohydrin
  • alpha-Hydrocodol
  • Drocode
  • Dihydrocodeinum
  • Diidrocodeina
  • Remedacen
  • DH-codeine
  • IDS-ND-008(SECT.2)
  • 3-Methoxy-12-methyl-5,6,7,7a,8,9-hexahydro-4aH-8,9c-iminoethanophenanthro(4,5-bcd)furan-5-ol
  • Morphinan-6-alpha-ol, 4,5-alpha-epoxy-3-methoxy-17-methyl-
  • Morphinan-6-ol, 4,5-epoxy-3-methoxy-17-methyl-, (5alpha,6alpha)-
  • (4R,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol
  • Paracodina
  • Dihydrocodeine Acid
  • (4R,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro(3,2-e)isoquinolin-7-ol
  • (4R,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro(3,2-e)isoquinoline-7-ol
  • (4R,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-ol
Show all 33 synonyms
  • Paracodin
  • Nadeine
  • Codeine, 7,8-dihydro-
  • Novicodin
  • Dihydrokodein
  • Dihydrocodeine (INN)
  • 6alpha-Hydrocodol
  • 6-alpha-Hydrocodol

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
301.39 g/molcalc.
Exact mass
301.1678 Dacalc.
LogP (octanol/water)
1.73calc.
Topological polar surface area
41.93 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
1calc.
Heavy atoms
22calc.
Rings
5calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.67calc.
Formal charge
0calc.
Stereocentres
5calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1cc2c3c(c1)OC1CCCC4C(C2)NCCC314

c1cc2c3c(c1)OC1CCCC4C(C2)NCCC314

5 rings, 18 atoms.

110 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H301 + H311 + H331Toxic if swallowed. Toxic in contact with skin. Toxic if inhaled.
  • H301Toxic if swallowed.
  • H311Toxic in contact with skin.
  • H317May cause an allergic skin reaction.
  • H331Toxic if inhaled.
  • H334May cause allergy or asthma symptoms or breathing difficulties if inhaled.
Precautionary statements (24)
  • P233Keep container tightly closed.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P262Do not get in eyes, on skin, or on clothing.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P284In case of inadequate ventilation wear respiratory protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P316Get emergency medical help immediately.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P342 + P316If experiencing respiratory symptoms: Get emergency medical help immediately.
  • P361 + P364Take off immediately all contaminated clothing. And wash it before reuse.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403Store in a well-ventilated place.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Dihydrocodeine suppliers

Trading restrictions apply to this substance

Narcotic drug

Dihydrocodeine is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: UN Single Convention on Narcotic Drugs 1961, HS 2022 subheading 2939.11 (opium alkaloids and their derivatives)

Our policy on controlled substances

Dihydrocodeine price

Indicative price range per kg from live supplier offers

Prices are not shown for prohibited substances.

Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Pharmacological actions

  • Analgesics, Opioid

Roles

  • analgesic
  • pharmaceutical

Pharmacology

Dihydrocodeine is an Opioid Agonist. The mechanism of action of dihydrocodeine is as a Full Opioid Agonist.

Regulatory status

Inventories, regulations and trade controls that list this substance

Narcotic drug

Dihydrocodeine is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: UN Single Convention on Narcotic Drugs 1961, HS 2022 subheading 2939.11 (opium alkaloids and their derivatives)

Our policy on controlled substances

Controls

  • US DEA controlled substance or listed chemical
  • Controlled narcotic drug

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Dihydrocodeine is traded under.

HS 2939.11Exact HS code

Concentrates of poppy straw, buprenorphine (INN), codeine, dihydrocodeine (INN)…

World exports in 2024
$246M
−3.8% vs 2023, imports $339M
2019 to 2024
Top exporters
  1. United Kingdom33.3%
  2. Spain21.3%
  3. Czech Republic8.6%
Top importers
  1. United States30.8%
  2. United Kingdom13.2%
  3. Germany6.3%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Dihydrocodeine is indicative (it was matched by name in the HS nomenclature). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Dihydrocodeine, based on the data on this page

What is Dihydrocodeine?

Dihydrocodeine is a morphinane alkaloid.

What is the CAS number of Dihydrocodeine?

The CAS registry number of Dihydrocodeine is 125-28-0.

What is the molecular formula and weight of Dihydrocodeine?

The molecular formula of Dihydrocodeine is C18H23NO3 and its molar mass is 301.39 g/mol.

What is Dihydrocodeine used for?

Use classes: Pharmaceuticals.

Is Dihydrocodeine hazardous?

Dihydrocodeine carries the GHS signal word "Danger". Main hazards: toxic if swallowed. toxic in contact with skin. toxic if inhaled, toxic if swallowed, toxic in contact with skin. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Dihydrocodeine?

Dihydrocodeine is usually classified under HS code 293911 (Concentrates of poppy straw, buprenorphine (INN), codeine, dihydrocodeine (INN)…). This is indicative, confirm it with your customs broker before shipping.

Can I buy Dihydrocodeine on CompoundList?

No. Dihydrocodeine is on our prohibited list, so listings, quotes and messages for it are disabled. This page is kept for information only.

Guides for buyers

Practical guides that help when you source, ship or handle Dihydrocodeine

Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page

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