CompoundList
Sign in
Hormones and steroids

Methylprednisolone

Also known as Medrate, Medrone, Urbason

CAS 83-43-2Formula C22H30O5Molar mass 374.48 g/molEC 201-476-4
GHS signal word: Danger. Pictograms: Harmful or irritant, Serious health hazard 116 suppliers listed Drug substance
Get quotes Compare 116 suppliers
Methylprednisolone chemical structure, C22H30O5, CAS 83-43-2
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals
Melting point
228 to 237
Solubility
MW 416.51, crystals, MP 205-208 °C, specific optical rotation: 101 deg at 20 °C (dioxane…
HS code
293729
Category
Hormones and steroids
Illustrative photo, a shrink wrapped pallet of kraft paper sacks in a chemical plant
Typical packagingIllustrative packaging image, not the actual product

What is Methylprednisolone?

Plain description, key identifiers and synonyms

6alpha-methylprednisolone is the 6alpha-stereoisomer of 6-methylprednisolone. It has a role as an anti-inflammatory drug, a xenobiotic, an adrenergic agent, an antiemetic, a neuroprotective agent and an environmental contaminant. It is a primary alpha-hydroxy ketone, a tertiary alpha-hydroxy ketone and a 6-methylprednisolone.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
CAS number
83-43-2 CAS number cross-checked
EC number
201-476-4
Molecular formula
C22H30O5
UNII
X4W7ZR7023
MDL number
MFCD00010591
InChIKey
VHRSUDSXCMQTMA-PJHHCJLFSA-N
InChI
InChI=1S/C22H30O5/c1-12-8-14-15-5-7-22(27,18(26)11-23)21(15,3)10-17(25)19(14)20(2)6-4-13(24)9-16(12)20/h4,6,9,12,14-15,17,19,23,25,27H,5,7-8,10-11H2,1-3H3/t12-,14-,15-,17-,19+,20-,21-,22-/m0/s1
Canonical SMILES
CC1CC2C(C(O)CC3(C)C2CCC3(O)C(=O)CO)C2(C)C=CC(=O)C=C12
Isomeric SMILES
C[C@H]1C[C@H]2[C@@H]3CC[C@@]([C@]3(C[C@@H]([C@@H]2[C@@]4(C1=CC(=O)C=C4)C)O)C)(C(=O)CO)O

Synonyms

  • Medrate
  • Medrone
  • Urbason
  • 6alpha-Methylprednisolone
  • Metilbetasone
  • Promacortine
  • Metastab
  • Metrisone
  • Wyacort
  • Dopomedrol
  • Medesone
  • Noretona
  • Suprametil
  • Besonia
  • Moderin
  • Solomet
  • Artisone-wyeth
  • Sieropresol
  • Esametone
  • Firmacort
  • Metrocort
  • Metysolon
  • Methylprednisolon
  • Medlone 21
  • Methylprednisolonum
Show all 39 synonyms
  • delta(1)-6alpha-Methylhydrocortisone
  • 1-Dehydro-6alpha-methylhydrocortisone
  • Summicort
  • 11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
  • (6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
  • 6alpha-Methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
  • 11beta,17alpha,21-Trihydroxy-6alpha-methyl-1,4-pregnadiene-3,20-dione
  • (6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
  • Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-6alpha-methyl-
  • Pregna-1,4-diene-3,20-dione, 11,17,21-trihydroxy-6-methyl-, (6alpha,11beta)-
  • Metipred
  • Solpredone
  • Duralone
  • Meprolone

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystalsexp.
Odour
Odorlessexp.
Melting point
228 to 237exp.
Solubility
MW 416.51, crystals, MP 205-208 °C, specific optical rotation: 101 deg at 20 °C (dioxane), uv max (95% ethanol): 243 nm (alpha m 14825), Sol in dioxane, sparingly sol in acetone, alcohol, chloroform, methanol, slightly sol in ether.exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
374.48 g/molcalc.
Exact mass
374.2093 Dacalc.
LogP (octanol/water)
1.8calc.
Topological polar surface area
94.83 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
2calc.
Heavy atoms
27calc.
Rings
4calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.73calc.
Formal charge
0calc.
Stereocentres
8calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1C=CC2C(=C1)CCC1C3CCCC3CCC21

O=C1C=CC2C(=C1)CCC1C3CCCC3CCC21

4 rings, 18 atoms.

956 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302Harmful if swallowed.
  • H312Harmful in contact with skin.
  • H360May damage fertility or the unborn child.
  • H361Suspected of damaging fertility or the unborn child.
  • H372Causes damage to organs through prolonged or repeated exposure.
  • H373May cause damage to organs through prolonged or repeated exposure.
Precautionary statements (15)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P317Get medical help.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Methylprednisolone suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 116 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

116 suppliers in 17 countries

Send one request to many suppliers

Choose up to 10 suppliers or let us match your request. Compare quotes side by side, free.

Choose suppliersPost a request

Methylprednisolone price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

Get latest price

Uses and applications

What the substance is used for, by industry and function

Used to treat rheumatoid arthritis.

Used in dogs and cats as an anti-inflammatory agent. (Medrol Tablets).

Used in dogs as an analgesic agent. (Cortoba Tablets).

Treatment of inflammation and related disorders in cats and dogs, treatment of allergic and dermatologic disorders in cats and dogs, and as supportive therapy to antibacterial treatment of severe infections in cats and dogs. Treatment of inflammation and related disorders in horses. (Depo-Medrol Sterile Aqueous Suspension).

Use classes: Pharmaceuticals, Animal Drugs.

Pharmacological actions

  • Anti-Inflammatory Agents
  • Antiemetics
  • Glucocorticoids
  • Neuroprotective Agents

Roles

  • adrenergic agent
  • analgesic
  • anti-anaemic agent
  • anti-asthmatic agent
  • anti-inflammatory agent
  • anti-inflammatory drug
  • antiatherosclerotic agent
  • antiemetic
  • antifibrotic agent
  • antiinfective agent
  • antimicrobial agent
  • antineoplastic agent
  • antiparkinson drug
  • antirheumatic drug
  • antispasmodic drug
  • cardiovascular drug
  • dermatologic drug
  • environmental contaminant
  • geroprotector
  • immunosuppressive agent
  • nephroprotective agent
  • neuroprotective agent
  • renoprotective agent
  • vulnerary

Pharmacology

Methylprednisolone is a Corticosteroid. The mechanism of action of methylprednisolone is as a Corticosteroid Hormone Receptor Agonist.

How it is made

Preparation: Sebek, Spero, US 2897218 (1959 to Upjohn), Gould, US 3053832 (1962 to Schering)

Cortisone is first converted to the 6-keto derivative via suitable intermediates. Subsequent Grignard reaction with methylmagnesium bromide and further reaction steps then yield 6a-methylprednisolone.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

United States

  • TSCA inventory (USA)
    Status: Inactive in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Methylprednisolone is traded under.

HS 2937.29Indicative HS code

Steroidal hormones, their derivatives and structural analogues, other

World exports in 2024
$2.32B
+5.7% vs 2023, imports $2.41B
2019 to 2024
Top exporters
  1. Belgium25.3%
  2. United States24.9%
  3. China13.0%
Top importers
  1. Italy18.0%
  2. Canada13.0%
  3. Belgium12.2%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Methylprednisolone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Methylprednisolone, based on the data on this page

What is Methylprednisolone?

6alpha-methylprednisolone is the 6alpha-stereoisomer of 6-methylprednisolone. It has a role as an anti-inflammatory drug, a xenobiotic, an adrenergic agent, an antiemetic, a neuroprotective agent and an environmental contaminant.

What is the CAS number of Methylprednisolone?

The CAS registry number of Methylprednisolone is 83-43-2.

What is the molecular formula and weight of Methylprednisolone?

The molecular formula of Methylprednisolone is C22H30O5 and its molar mass is 374.48 g/mol.

What is Methylprednisolone used for?

Used to treat rheumatoid arthritis. Used in dogs and cats as an anti-inflammatory agent. (Medrol Tablets). Used in dogs as an analgesic agent. (Cortoba Tablets).

Is Methylprednisolone hazardous?

Methylprednisolone carries the GHS signal word "Danger". Main hazards: harmful if swallowed, harmful in contact with skin, may damage fertility or the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Methylprednisolone?

Methylprednisolone is usually classified under HS code 293729 (Steroidal hormones, their derivatives and structural analogues, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Methylprednisolone?

CompoundList lists 116 suppliers of Methylprednisolone in India, United States, China, United Kingdom and 13 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Methylprednisolone in India?

35 suppliers in India list Methylprednisolone on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Methylprednisolone?

Suppliers quote Methylprednisolone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Methylprednisolone

Get quotes for Methylprednisolone

Post one free request with your grade, quantity and destination. Matching suppliers send quotes you can compare side by side.
Post a request Sell Methylprednisolone
Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
Embed this structure on your websiteShow code

Paste this code into your page to show the 2D structure of Methylprednisolone with a 3D view, its CAS number where known and a link back to this page. Free to use with the link kept.

<iframe src="https://www.compoundlist.com/embed/structure/methylprednisolone-83-43-2" title="Methylprednisolone structure on CompoundList" width="360" height="420" style="border:1px solid #E7E2DA;border-radius:12px;max-width:100%" loading="lazy" referrerpolicy="strict-origin-when-cross-origin"></iframe>
Preview the embed

Explore more in Hormones and steroids or HS code 293729

116 suppliers
Free quotes, contact stays private
Get quotes