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Alkaloids

(-)-Mitragynine

Also known as Mitragynine, 9-Methoxycorynantheidine, Skf 12711

CAS 4098-40-2Formula C23H30N2O4Molar mass 398.50 g/molEC 863-118-9
GHS signal word: Warning. Pictograms: Harmful or irritant 3 suppliers listed
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(-)-Mitragynine chemical structure, C23H30N2O4, CAS 4098-40-2
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
White amorphous powder
Melting point
104 °C
Boiling point
235 °C
Solubility
Soluble in alcohol, chloroform, acetic acid
HS code
293979
Category
Alkaloids
Illustrative photo, fine white powder in a clear glass bottle on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is (-)-Mitragynine?

Plain description, key identifiers and synonyms

Mitragynine is a monoterpenoid indole alkaloid.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
methyl (E)-2-[(2S,3S,12bS)-3-ethyl-8-methoxy-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-2-yl]-3-methoxyprop-2-enoate
CAS number
4098-40-2 CAS number cross-checked
EC number
863-118-9
Molecular formula
C23H30N2O4
UNII
EP479K822J
InChIKey
LELBFTMXCIIKKX-QVRQZEMUSA-N
InChI
InChI=1S/C23H30N2O4/c1-5-14-12-25-10-9-15-21-18(7-6-8-20(21)28-3)24-22(15)19(25)11-16(14)17(13-27-2)23(26)29-4/h6-8,13-14,16,19,24H,5,9-12H2,1-4H3/b17-13+/t14-,16+,19+/m1/s1
Canonical SMILES
CCC1CN2CCc3c([nH]c4cccc(OC)c34)C2CC1C(=COC)C(=O)OC
Isomeric SMILES
CC[C@@H]1CN2CCC3=C([C@@H]2C[C@@H]1/C(=C\OC)/C(=O)OC)NC4=C3C(=CC=C4)OC

Synonyms

  • Mitragynine
  • 9-Methoxycorynantheidine
  • Skf 12711
  • methyl (E)-2-[(2S,3S,12bS)-3-ethyl-8-methoxy-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-2-yl]-3-methoxyprop-2-enoate
  • 16,17-Didehydro-9,17-dimethoxy-17,18-seco-20-alpha-yohimban-16-carboxylic acid methyl ester
  • methyl (2E)-2-((2S,4S,5S)-5-ethyl-12-methoxy-7,17-diazatetracyclo(8.7.0.0^(2,7).0^(11,16))heptadeca-1(10),11,13,15-tetraen-4-yl)-3-methoxyprop-2-enoate
  • methyl (2E)-2-[(2S,4S,5S)-5-ethyl-12-methoxy-7,17-diazatetracyclo[8.7.0.0^{2,7}.0^{11,16}]heptadeca-1(10),11,13,15-tetraen-4-yl]-3-methoxyprop-2-enoate
  • methyl (E)-2-((2S,3S,12bS)-3-ethyl-8-methoxy-1,2,3,4,6,7,12,12b-octahydroindolo(2,3-a)quinolizin-2-yl)-3-methoxyprop-2-enoate
  • SK&F-12711
  • (E)-Methyl 2-((2S,3S,12bS)-3-ethyl-8-methoxy-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-2-yl)-3-methoxyacrylate
  • Mitragynine (100?g/mL in Methanol)
  • Mitragynin
  • SK&F 12711
  • Mitragynine - 95%
  • Mitragynine - 97%
  • Mitragynine, 1mg/ml in Methanol
  • Mitragynine, 0.1mg/ml in Methanol
  • Mitragynine (100 ug/mL in Methanol)
  • Mitragynine 100 microg/mL in Methanol
  • methyl (E)-2-[(2S,3S,12bS)-3-ethyl-8-methoxy-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-2-yl]-3-methoxy-prop-2-enoate
  • Corynan-16-carboxylic acid, 16,17-didehydro-9,17-dimethoxy-, methyl ester, (16E,20beta)-
  • (a-E,2S,3S,12bS)-3-Ethyl-1,2,3,4,6,7,12 ,12b-octahydro-8-methoxy-a-(methoxymethylene)-indolo[2 ,3-a]quinolizine-2-acetic acid methyl ester
  • (E)-methyl2-((2s,3s,12bs)-3-ethyl-8-methoxy-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-2-yl)-3-methoxyacrylate
  • Indolo[2,3-a]quinolizine-2-acetic acid, 3-ethyl-1,2,3,4,6,7,12,12b-octahydro-8-methoxy-alpha-(methoxymethylene)-, methyl ester, (alphaE,2S,3S,12bS)-
  • methyl (E)-2-((2S,3S,12bS)-3-ethyl-8-methoxy-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-2-yl)-3-methoxyacrylate
Show all 26 synonyms
  • methyl(e)-2-[(2s,3s,12bs)-3-ethyl-8-methoxy-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-2-yl]-3-methoxyprop-2-enoate

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
White amorphous powderexp.
Melting point
104 °Cexp.
Boiling point
235 °Cexp.
Solubility
Soluble in alcohol, chloroform, acetic acidexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
398.50 g/molcalc.
Exact mass
398.2206 Dacalc.
LogP (octanol/water)
3.83calc.
Topological polar surface area
63.79 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
5calc.
Heavy atoms
29calc.
Rings
4calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.52calc.
Formal charge
0calc.
Stereocentres
3calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2c3c([nH]c2c1)C1CCCCN1CC3

c1ccc2c3c([nH]c2c1)C1CCCCN1CC3

4 rings, 17 atoms, the 1,2,3,4,6,7,12,12b-Octahydroindolo(2,3-a)quinolizine ring system.

58 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H317May cause an allergic skin reaction.
  • H319Causes serious eye irritation.
Precautionary statements (11)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

(-)-Mitragynine suppliers

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All 3 suppliers

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Where suppliers are based

3 suppliers in 2 countries

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(-)-Mitragynine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

The Thai medicinal plant Mitragyna speciosa (kratom) is misused as a herbal drug. Besides this, a new herbal blend has appeared on the drugs of abuse market, named Krypton, a mixture of O-demethyltramadol (ODT) and kratom. (Kratom).

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code (-)-Mitragynine is traded under.

HS 2939.79Indicative HS code

Alkaloids of vegetal origin, other than cocaine, ecgonine, salts, esters and other derivatives, not elsewhere…

World exports in 2024
$701M
+18.9% vs 2023, imports $830M
2019 to 2024
Top exporters
  1. Switzerland * partner reported25.3%
  2. Germany21.4%
  3. India * partner reported14.9%
Top importers
  1. United States20.9%
  2. Germany14.7%
  3. Italy14.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for (-)-Mitragynine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about (-)-Mitragynine, based on the data on this page

What is (-)-Mitragynine?

Mitragynine is a monoterpenoid indole alkaloid.

What is the CAS number of (-)-Mitragynine?

The CAS registry number of (-)-Mitragynine is 4098-40-2.

What is the molecular formula and weight of (-)-Mitragynine?

The molecular formula of (-)-Mitragynine is C23H30N2O4 and its molar mass is 398.50 g/mol.

What is (-)-Mitragynine used for?

The Thai medicinal plant Mitragyna speciosa (kratom) is misused as a herbal drug. Besides this, a new herbal blend has appeared on the drugs of abuse market, named Krypton, a mixture of O-demethyltramadol (ODT) and kratom. (Kratom).

Is (-)-Mitragynine hazardous?

(-)-Mitragynine carries the GHS signal word "Warning". Main hazards: may cause an allergic skin reaction, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of (-)-Mitragynine?

(-)-Mitragynine is usually classified under HS code 293979 (Alkaloids, natural or reproduced by synthesis, and their salts, ethers, esters and other…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy (-)-Mitragynine?

CompoundList lists 3 suppliers of (-)-Mitragynine in United States and China. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of (-)-Mitragynine?

Suppliers quote (-)-Mitragynine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle (-)-Mitragynine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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