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Alkaloids

Pholcodine

Also known as Homocodeine, Glycodine, Codylin

CAS 509-67-1Formula C23H30N2O4Molar mass 398.50 g/molEC 208-102-9
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant Prohibited, not for trade
Why it is not for trade
Pholcodine chemical structure, C23H30N2O4, CAS 509-67-1
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
509-67-1
Formula
C23H30N2O4
Molar mass
398.50 g/mol
EC number
208-102-9
HS code
293911
Category
Alkaloids

What is Pholcodine?

Plain description, key identifiers and synonyms

Pholcodine is a morphinane alkaloid that is a derivative of morphine with a 2-morpholinoethyl group at the 3-position. It has a role as an opioid analgesic, an antitussive, a mu-opioid receptor agonist and a drug allergen. It is a morphinane alkaloid and an organic heteropentacyclic compound.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(4R,4aR,7S,7aR,12bS)-3-methyl-9-(2-morpholin-4-ylethoxy)-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol
CAS number
509-67-1 CAS number cross-checked
EC number
208-102-9
Molecular formula
C23H30N2O4
UNII
LPP64AWZ7L
InChIKey
GPFAJKDEDBRFOS-FKQDBXSBSA-N
InChI
InChI=1S/C23H30N2O4/c1-24-7-6-23-16-3-4-18(26)22(23)29-21-19(5-2-15(20(21)23)14-17(16)24)28-13-10-25-8-11-27-12-9-25/h2-5,16-18,22,26H,6-14H2,1H3/t16-,17+,18-,22-,23-/m0/s1
Canonical SMILES
CN1CCC23c4c5ccc(OCCN6CCOCC6)c4OC2C(O)C=CC3C1C5
Isomeric SMILES
CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)OCCN6CCOCC6)O[C@H]3[C@H](C=C4)O

Synonyms

  • Homocodeine
  • Glycodine
  • Codylin
  • Folcodine
  • Neocodine
  • Weifacodine
  • Hibernyl
  • Pholtex
  • Memine
  • Morpholinylethylmorphine
  • Tussokon
  • Ethnine
  • Folcodina
  • Galenphol
  • Biocalyptol
  • Pholcodinum
  • Dia-Tuss
  • Ethnine Simplex
  • 3-Morpholylaethylmorphin
  • beta-Morpholinoethylmorphine
  • 3-(2-(4-Morpholinyl)ethyl)morphine
  • Tetrahydro-1,4-oxazinylmethylcodeine
  • DEA No. 9314
  • Pavacol-D
  • IDS-NP-011(SECT.2)
Show all 39 synonyms
  • 7,8-Didehydro-4,5-alpha-epoxy-17-methyl-3-(2-morpholinoethoxy)morphinan-6-alpha-ol
  • Evaphol
  • Tixylix daytime
  • Evaphol strong
  • Pholcomed fte
  • Gppe linct
  • Sancos co
  • Tixylix dry cough
  • Tixylix night-time
  • (1S,5R,13R,14S,17R)-4-methyl-10-(2-(morpholin-4-yl)ethoxy)-12-oxa-4-azapentacyclo(9.6.1.0^(1,13).0^(5,17).0^(7,18))octadeca-7(18),8,10,15-tetraen-14-ol
  • (1S,5R,13R,14S,17R)-4-methyl-10-[2-(morpholin-4-yl)ethoxy]-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7(18),8,10,15-tetraen-14-ol
  • (4R,4aR,7S,7aR,12bS)-3-methyl-9-(2-morpholin-4-ylethoxy)-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro(3,2-e)isoquinoline-7-o
  • (4R,4aR,7S,7aR,12bS)-3-methyl-9-(2-morpholin-4-ylethoxy)-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-o
  • Tixylix night cough

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
398.50 g/molcalc.
Exact mass
398.2206 Dacalc.
LogP (octanol/water)
1.2calc.
Topological polar surface area
54.4 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
4calc.
Heavy atoms
29calc.
Rings
6calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.65calc.
Formal charge
0calc.
Stereocentres
5calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1=CC2C3Cc4ccc(OCCN5CCOCC5)c5c4C2(CCN3)C(C1)O5

C1=CC2C3Cc4ccc(OCCN5CCOCC5)c5c4C2(CCN3)C(C1)O5

6 rings, 27 atoms.

13 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H301Toxic if swallowed.
  • H302Harmful if swallowed.
  • H311Toxic in contact with skin.
  • H312Harmful in contact with skin.
  • H331Toxic if inhaled.
  • H332Harmful if inhaled.
Precautionary statements (19)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P262Do not get in eyes, on skin, or on clothing.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P316Get emergency medical help immediately.
  • P317Get medical help.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P361 + P364Take off immediately all contaminated clothing. And wash it before reuse.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Pholcodine suppliers

Trading restrictions apply to this substance

Narcotic drug

Pholcodine is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: UN Single Convention on Narcotic Drugs 1961, HS 2022 subheading 2939.11 (opium alkaloids and their derivatives)

Our policy on controlled substances

Pholcodine price

Indicative price range per kg from live supplier offers

Prices are not shown for prohibited substances.

Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Pharmacological actions

  • Analgesics
  • Antitussive Agents

Roles

  • aetiopathogenetic role
  • agonist
  • allergen
  • analgesic
  • antitussive
  • drug allergen
  • mu-opioid agent
  • mu-opioid receptor agonist
  • neurotransmitter agent
  • opioid agent
  • opioid analgesic
  • opioid receptor agonist
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

Narcotic drug

Pholcodine is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: UN Single Convention on Narcotic Drugs 1961, HS 2022 subheading 2939.11 (opium alkaloids and their derivatives)

Our policy on controlled substances

Controls

  • US DEA controlled substance or listed chemical
  • Controlled narcotic drug

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Pholcodine is traded under.

HS 2939.11Exact HS code

Concentrates of poppy straw, buprenorphine (INN), codeine, dihydrocodeine (INN)…

World exports in 2024
$246M
−3.8% vs 2023, imports $339M
2019 to 2024
Top exporters
  1. United Kingdom33.3%
  2. Spain21.3%
  3. Czech Republic8.6%
Top importers
  1. United States30.8%
  2. United Kingdom13.2%
  3. Germany6.3%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Pholcodine is indicative (it was matched by name in the HS nomenclature). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Pholcodine, based on the data on this page

What is Pholcodine?

Pholcodine is a morphinane alkaloid that is a derivative of morphine with a 2-morpholinoethyl group at the 3-position. It has a role as an opioid analgesic, an antitussive, a mu-opioid receptor agonist and a drug allergen. It is a morphinane alkaloid and an organic heteropentacyclic compound.

What is the CAS number of Pholcodine?

The CAS registry number of Pholcodine is 509-67-1.

What is the molecular formula and weight of Pholcodine?

The molecular formula of Pholcodine is C23H30N2O4 and its molar mass is 398.50 g/mol.

What is Pholcodine used for?

Use classes: Pharmaceuticals.

Is Pholcodine hazardous?

Pholcodine carries the GHS signal word "Danger". Main hazards: toxic if swallowed, harmful if swallowed, toxic in contact with skin. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Pholcodine?

Pholcodine is usually classified under HS code 293911 (Concentrates of poppy straw, buprenorphine (INN), codeine, dihydrocodeine (INN)…). This is indicative, confirm it with your customs broker before shipping.

Can I buy Pholcodine on CompoundList?

No. Pholcodine is on our prohibited list, so listings, quotes and messages for it are disabled. This page is kept for information only.

Guides for buyers

Practical guides that help when you source, ship or handle Pholcodine

Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page

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