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Screening compounds

Mrtx0902

Also known as MRTX-0902, (R)-2-Methyl-3-(1-((4-methyl-7-morpholinopyrido[3,4-d]pyridazin-1-yl)amino)ethyl)benzonitrile, (R)-2-Methyl-3-(1-((4-methyl-7-morpholinopyrido(3,4-d)pyridazin-1-yl)amino)ethyl)benzonitrile

CAS 2654743-22-1Formula C22H24N6OMolar mass 388.48 g/mol
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Mrtx0902 chemical structure, C22H24N6O, CAS 2654743-22-1
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
2654743-22-1
Formula
C22H24N6O
Molar mass
388.48 g/mol
HS code
293499
Category
Screening compounds

What is Mrtx0902?

Plain description, key identifiers and synonyms

SOS1 Inhibitor MRTX0902 is an orally available, brain-penetrant, phthalazine-based inhibitor of the guanine nucleotide exchange factor (GEF) Son of sevenless homolog 1 (SOS1), with potential antineoplastic activity. Upon oral administration, SOS1 inhibitor MRTX0902 selectively targets and binds to SOS1, thereby preventing the interaction of SOS1 with Kirsten rat sarcoma viral oncogene homolog (KRAS) in the guanosine diphosphate (GDP)-bound 'off' state, which is the inactivated state of KRAS. This abrogates the exchange of RAS-bound GDP for guanosine triphosphate (GTP) and prevents the formation of GTP-loaded KRAS, which is the activated 'on' state of KRAS. This prevents activation of downstream RAF/mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) signaling pathway by GTP-loaded KRAS.

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This inhibits mutant KRAS-dependent signaling and may inhibit growth and survival of KRAS-expressing tumor cells. KRAS is a member of the RAS family of oncogenes that is mutated in many cancer cell types. Mutations of KRAS may induce constitutive signal transduction leading to tumor cell proliferation, survival, invasion, and metastasis. SOS1 regulates the KRAS GDP-GTP cycle and promotes nucleotide exchange and formation of 'active' KRAS-GTP.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-methyl-3-[(1R)-1-[(4-methyl-7-morpholin-4-ylpyrido[3,4-d]pyridazin-1-yl)amino]ethyl]benzonitrile
CAS number
2654743-22-1
Molecular formula
C22H24N6O
UNII
CRG69FR93G
MDL number
MFCD34662948
InChIKey
ILPWEAHQRAWJIU-OAHLLOKOSA-N
InChI
InChI=1S/C22H24N6O/c1-14-17(12-23)5-4-6-18(14)15(2)25-22-19-11-21(28-7-9-29-10-8-28)24-13-20(19)16(3)26-27-22/h4-6,11,13,15H,7-10H2,1-3H3,(H,25,27)/t15-/m1/s1
Canonical SMILES
Cc1c(C#N)cccc1C(C)Nc1nnc(C)c2cnc(N3CCOCC3)cc12
Isomeric SMILES
CC1=C(C=CC=C1[C@@H](C)NC2=NN=C(C3=CN=C(C=C32)N4CCOCC4)C)C#N

Synonyms

  • MRTX-0902
  • (R)-2-Methyl-3-(1-((4-methyl-7-morpholinopyrido[3,4-d]pyridazin-1-yl)amino)ethyl)benzonitrile
  • (R)-2-Methyl-3-(1-((4-methyl-7-morpholinopyrido(3,4-d)pyridazin-1-yl)amino)ethyl)benzonitrile
  • Benzonitrile, 2-methyl-3-((1R)-1-((4-methyl-7-(4-morpholinyl)pyrido(3,4-d)pyridazin-1-yl)amino)ethyl)-
  • MRTX 0902
  • (R)-2-Methyl-3-[1-[(4-methyl-7-morpholinopyrido[3,4-d]pyridazin-1-yl)amino]ethyl]benzonitrile
  • SOS1 Inhibitor MRTX0902
  • 2-Methyl-3-[(1R)-1-[(4-methyl-7-morpholin-4-ylpyrido[3,4-d]pyridazin-1-yl)amino]ethyl]benzonitrile
  • 2-methyl-3-[(1R)-1-{[4-methyl-7-(morpholin-4-yl)pyrido[3,4-d]pyridazin-1-yl]amino}ethyl]benzonitrile
  • MRTX0902, MRTX-0902, MRTX 0902
  • MRTX0902?
  • NKF

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
388.48 g/molcalc.
Exact mass
388.2012 Dacalc.
LogP (octanol/water)
3.52calc.
Topological polar surface area
86.96 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
7calc.
Rotatable bonds
4calc.
Heavy atoms
29calc.
Rings
4calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.36calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(CNc2nncc3cnc(N4CCOCC4)cc23)cc1

c1ccc(CNc2nncc3cnc(N4CCOCC4)cc23)cc1

4 rings, 24 atoms.

1 other chemical share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Mrtx0902 suppliers

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Mrtx0902 price

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Uses and applications

What the substance is used for, by industry and function

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Mrtx0902 is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Mrtx0902 is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Mrtx0902, based on the data on this page

What is Mrtx0902?

SOS1 Inhibitor MRTX0902 is an orally available, brain-penetrant, phthalazine-based inhibitor of the guanine nucleotide exchange factor (GEF) Son of sevenless homolog 1 (SOS1), with potential antineoplastic activity.

What is the CAS number of Mrtx0902?

The CAS registry number of Mrtx0902 is 2654743-22-1.

What is the molecular formula and weight of Mrtx0902?

The molecular formula of Mrtx0902 is C22H24N6O and its molar mass is 388.48 g/mol.

What is Mrtx0902 used for?

Known uses and roles of Mrtx0902 include building blocks in research and laboratory and screening compounds in research and laboratory.

Is Mrtx0902 hazardous?

No GHS hazard classification for Mrtx0902 is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Mrtx0902?

Mrtx0902 is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Mrtx0902?

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What is the price of Mrtx0902?

Suppliers quote Mrtx0902 on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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