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Impurities and reference standards

N,N,N',N'-Tetramethylbenzidine

Also known as N,N,N',N'-Tetramethyl-(1,1'-biphenyl)-4,4'-diamine, n,n,n,n-tetramethylbenzidine, Benzidine, N,N,N',N'-tetramethyl-

CAS 366-29-0Formula C16H20N2Molar mass 240.35 g/molEC 206-676-5
GHS signal word: Warning. Pictograms: Harmful or irritant 5 suppliers listed
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N,N,N',N'-Tetramethylbenzidine chemical structure, C16H20N2, CAS 366-29-0
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
366-29-0
Formula
C16H20N2
Molar mass
240.35 g/mol
EC number
206-676-5
HS code
292159
Category
Impurities and reference standards

What is N,N,N',N'-Tetramethylbenzidine?

Plain description, key identifiers and synonyms

N,N,N',N'-Tetramethylbenzidine is a chemical substance with the molecular formula C16H20N2 and a molar mass of 240.35 g/mol. Its CAS registry number is 366-29-0. The IUPAC name is 4-[4-(dimethylamino)phenyl]-N,N-dimethylaniline.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-[4-(dimethylamino)phenyl]-N,N-dimethylaniline
CAS number
366-29-0 CAS number cross-checked
EC number
206-676-5
Molecular formula
C16H20N2
UNII
2Q6KUH7P3S
MDL number
MFCD00008310
InChIKey
YRNWIFYIFSBPAU-UHFFFAOYSA-N
InChI
InChI=1S/C16H20N2/c1-17(2)15-9-5-13(6-10-15)14-7-11-16(12-8-14)18(3)4/h5-12H,1-4H3
SMILES (canonical and isomeric)
CN(C)C1=CC=C(C=C1)C2=CC=C(C=C2)N(C)C

Synonyms

  • N,N,N',N'-Tetramethyl-(1,1'-biphenyl)-4,4'-diamine
  • n,n,n,n-tetramethylbenzidine
  • Benzidine, N,N,N',N'-tetramethyl-
  • 4,4'-Bis(dimethylamino)biphenyl
  • N4,N4,N4',N4'-tetramethyl-[1,1'-biphenyl]-4,4'-diamine
  • 4,4'-Bis(N,N-dimethylamino)biphenyl
  • N,N,N',N'-Tetramethyl-p,p'-benzidine
  • [1,1'-Biphenyl]-4,4'-diamine, N,N,N',N'-tetramethyl-
  • (1,1'-Biphenyl)-4,4'-diamine, N,N,N',N'-tetramethyl-
  • 4-[4-(dimethylamino)phenyl]-N,N-dimethylaniline
  • 4,4'-Bis(dimethylamino)-1,1'-biphenyl
  • Ulipristal Impurity 8
  • {4-[4-(dimethylamino)phenyl]phenyl}dimethylamine
  • (1,1'-Biphenyl)-4,4'-diamine, N4,N4,N4',N4'-tetramethyl-
  • [1,1'-Biphenyl]-4,4'-diamine, N4,N4,N4',N4'-tetramethyl-
  • N,N',N'-Tetramethylbenzidine
  • Benzidine,N,N',N'-tetramethyl-
  • N,N,N'',N''-Tetramethylbenzidine
  • Tetramethylbenzidine, N,N,N',N'-
  • [1,4'-diamine, N,N,N',N'-tetramethyl-
  • 4-[4-(dimethylamino)phenyl]-N,N-dimethyl-aniline
  • N,N,N',N'-Tetramethylbenzidine, >=95% (HPLC)
  • [1,1'-Biphenyl]-4,4'-diamine,N,N,N'',N'-tetramethyl-
  • N,N,N',N'-Tetramethyl(1,1'-biphenyl)-4,4'-diamine
  • N,N-Dimethyl-(4'-(dimethylamino)biphenyl-4-yl)amine
Show all 28 synonyms
  • N-[4'-(dimethylamino)[1,1'-biphenyl]-4-yl]-N,N-dimethylamine
  • N~4~,N~4~,N~4'~,N~4'~-Tetramethyl[1,1'-biphenyl]-4,4'-diamine
  • N4,N4,N4 inverted exclamation mark ,N4 inverted exclamation mark -Tetramethyl-[1,1 inverted exclamation mark -biphenyl]-4,4 inverted exclamation mark -diamine

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
240.35 g/molcalc.
Exact mass
240.1626 Dacalc.
LogP (octanol/water)
3.49calc.
Topological polar surface area
6.48 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
3calc.
Heavy atoms
18calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.25calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(-c2ccccc2)cc1

c1ccc(-c2ccccc2)cc1

2 rings, 12 atoms, the Biphenyl ring system.

32,228 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (16)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

N,N,N',N'-Tetramethylbenzidine suppliers

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Where suppliers are based

5 suppliers in 4 countries

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N,N,N',N'-Tetramethylbenzidine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Applications are not documented for this substance yet. Suppliers often describe uses on their product pages, linked in the suppliers list above.

Regulatory status

Inventories, regulations and trade controls that list this substance

United States

  • TSCA inventory (USA)
    Status: Inactive in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code N,N,N',N'-Tetramethylbenzidine is traded under.

HS 2921.59Indicative HS code

Aromatic polyamines and their derivatives, salts thereof, other

World exports in 2024
$510M
−0.4% vs 2023, imports $488M
2019 to 2024
Top exporters
  1. China26.6%
  2. Japan16.6%
  3. India * partner reported12.4%
Top importers
  1. United States17.9%
  2. Germany11.6%
  3. South Korea7.4%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for N,N,N',N'-Tetramethylbenzidine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about N,N,N',N'-Tetramethylbenzidine, based on the data on this page

What is N,N,N',N'-Tetramethylbenzidine?

N,N,N',N'-Tetramethylbenzidine is a chemical substance with the molecular formula C16H20N2 and a molar mass of 240.35 g/mol. Its CAS registry number is 366-29-0. The IUPAC name is 4-[4-(dimethylamino)phenyl]-N,N-dimethylaniline.

What is the CAS number of N,N,N',N'-Tetramethylbenzidine?

The CAS registry number of N,N,N',N'-Tetramethylbenzidine is 366-29-0.

What is the molecular formula and weight of N,N,N',N'-Tetramethylbenzidine?

The molecular formula of N,N,N',N'-Tetramethylbenzidine is C16H20N2 and its molar mass is 240.35 g/mol.

Is N,N,N',N'-Tetramethylbenzidine hazardous?

N,N,N',N'-Tetramethylbenzidine carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation, may cause respiratory irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of N,N,N',N'-Tetramethylbenzidine?

N,N,N',N'-Tetramethylbenzidine is usually classified under HS code 292159 (Aromatic polyamines and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy N,N,N',N'-Tetramethylbenzidine?

CompoundList lists 5 suppliers of N,N,N',N'-Tetramethylbenzidine in China, India, Singapore and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy N,N,N',N'-Tetramethylbenzidine in India?

1 supplier in India list N,N,N',N'-Tetramethylbenzidine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of N,N,N',N'-Tetramethylbenzidine?

Suppliers quote N,N,N',N'-Tetramethylbenzidine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle N,N,N',N'-Tetramethylbenzidine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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