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Central nervous system drugs

Nabilone

Also known as Cesamet, Nabilona, Nabilonum

CAS 51022-71-0Formula C24H36O3Molar mass 372.55 g/molEC 637-087-5
GHS signal word: Warning. Pictograms: Harmful or irritant Prohibited, not for trade Drug substance
Why it is not for trade
Nabilone chemical structure, C24H36O3, CAS 51022-71-0
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
51022-71-0
Formula
C24H36O3
Molar mass
372.55 g/mol
EC number
637-087-5
HS code
293299
Category
Central nervous system drugs

What is Nabilone?

Plain description, key identifiers and synonyms

Nabilone is a synthetic cannabinoid and dibenzopyrane derivative with anti-emetic activity. Although the mechanism of action has not been fully elucidated yet, it has been suggested that nabilone is a highly selective and strong agonist for the cannabinoid receptors CB1 and CB2, both of which are coupled to Gi/o proteins. The CB1 receptors are expressed predominantly in central and peripheral neurons and receptor stimulation has been implicated in the reduction of chemotherapy-induced nausea.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(6aR,10aR)-1-hydroxy-6,6-dimethyl-3-(2-methyloctan-2-yl)-7,8,10,10a-tetrahydro-6aH-benzo[c]chromen-9-one
CAS number
51022-71-0 CAS number cross-checkedOther or deprecated CAS: 61617-09-2
EC number
637-087-5
Molecular formula
C24H36O3
UNII
2N4O9L084N
InChIKey
GECBBEABIDMGGL-RTBURBONSA-N
InChI
InChI=1S/C24H36O3/c1-6-7-8-9-12-23(2,3)16-13-20(26)22-18-15-17(25)10-11-19(18)24(4,5)27-21(22)14-16/h13-14,18-19,26H,6-12,15H2,1-5H3/t18-,19-/m1/s1
Canonical SMILES
CCCCCCC(C)(C)c1cc(O)c2c(c1)OC(C)(C)C1CCC(=O)CC21
Isomeric SMILES
CCCCCCC(C)(C)C1=CC(=C2[C@@H]3CC(=O)CC[C@H]3C(OC2=C1)(C)C)O

Synonyms

  • Cesamet
  • Nabilona
  • Nabilonum
  • CPD 109514
  • (6Ar,10ar)-1-hydroxy-6,6-dimethyl-3-(2-methyloctan-2-yl)-6H,6ah,7H,8H,9H,10H,10ah-benzo[c]isochromen-9-one
  • LY 109514
  • (6aR,10aR)-1-hydroxy-6,6-dimethyl-3-(2-methyloctan-2-yl)-6H,6aH,7H,8H,9H,10H,10aH-benzo(c)isochromen-9-one
  • 1-hydroxy-6,6-dimethyl-3-(2-methyloctan-2-yl)-7,8,10,10a-tetrahydro-6aH-benzo(c)chromen-9-one
  • (6aR,10aR)-1-hydroxy-6,6-dimethyl-3-(2-methyloctan-2-yl)-7,8,10,10a-tetrahydro-6aH-benzo[c]chromen-9-one
  • Nabilone (1.0 mg/mL in Acetonitrile)
  • (-)-Nabilone
  • (6aR,10aR)-1-Hydroxy-6,6-dimethyl-3-(2-methyloctan-2-yl)-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-one
  • 9H-Dibenzo(b,d)pyran-9-one, 3-(1,1-dimethylheptyl)-6,6a,7,8,10,10a-hexahydro-1-hydroxy-6,6-dimethyl-, (6aR,10aR)-rel-
  • 9H-Dibenzo[b,d]pyran-9-one, 3-(1,1-dimethylheptyl)-6,6a,7,8,10,10a-hexahydro-1-hydroxy-6,6-dimethyl-, (6aR,10aR)-rel-
  • Cesamet (TN)
  • Nabilone (USAN/INN)
  • DEA No. 7379
  • Nabilone (1 mg/mL in Acetonitrile)
  • Nabilone, solid, >=98% (HPLC)
  • (+-)-3-(1,1-Dimethylheptyl)-6,6abeta,7,8,10,10aalpha-hexahydro-1-hydroxy-6,6-dimethyl-9H-dibenzo(b,d)pyran-9-one
  • (+-)-trans-3-(1,1-Dimethylheptyl)-6a,7,8,9,10,10a-hexahydro-1-hydroxy-6,6-dimethyl-6H-dibenzo(b,d)pyran-9-on
  • (+-)-trans-3-(1,1-Dimethylheptyl-7,8,10,10a-tetrahydro-1-hydroxy-6,6-dimethyl-6H-dibenzo(b,d)pyran-9(6aH)-on
  • (+-)-trans-3-(1,1-Dimethylheptyl)-6,6a,7,8,10,10a-hexahydro-1-hydroxy-6,6-dimethyl-9H-dibenzo(b,d)pyran-9-one
  • (+/-)-3-(1,1-Dimethylheptyl-6,6a.beta.,7,8,10,10a.alpha.-hexahydro-1-hydroxy-6,6-dimethyl-9H-dibenzo(b,d)pyran-9-one
  • (-)-trans-1-hydroxy-3-(1,1-dimethylheptyl)-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]-pyran-9-one
Show all 28 synonyms
  • (-)-trans-1-Hydroxy-3-(1,1-dimethylheptyl)-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-one
  • (-)-trans-3-(1,1-dimethylheptyl)-6,6a,7,8,10,10a-hexahydro-1-hydroxy-6,6-dimethyl-9h-dibenzo[b,d]pyran-9-one
  • (6aR,10aR)-1-hydroxy-6,6-dimethyl-3-(2-methyloctan-2-yl)-7,8,10,10a-tetrahydro-6H-benzo[c]chromen-9(6aH)-one

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
372.55 g/molcalc.
Exact mass
372.2664 Dacalc.
LogP (octanol/water)
6.26calc.
Topological polar surface area
46.53 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
6calc.
Heavy atoms
27calc.
Rings
3calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.71calc.
Formal charge
0calc.
Stereocentres
2calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CCC2COc3ccccc3C2C1

O=C1CCC2COc3ccccc3C2C1

3 rings, 15 atoms.

8 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
Precautionary statements (5)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P317If swallowed: Get medical help.
  • P330Rinse mouth.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Nabilone suppliers

Trading restrictions apply to this substance

Psychotropic substance

Nabilone is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Nabilone

Reference: US DEA Schedule I or II

Our policy on controlled substances

Nabilone price

Indicative price range per kg from live supplier offers

Prices are not shown for prohibited substances.

Uses and applications

What the substance is used for, by industry and function

Industries and functions

Pharmacological actions

  • Anti-Anxiety Agents
  • Antiemetics

Pharmacology

Nabilone is a Cannabinoid.

Regulatory status

Inventories, regulations and trade controls that list this substance

Psychotropic substance

Nabilone is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Nabilone

Reference: US DEA Schedule I or II

Our policy on controlled substances

Controls

  • US DEA controlled substance or listed chemical

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Nabilone is traded under.

HS 2932.99Indicative HS code

Heterocyclic compounds with oxygen hetero-atom(s) only, other

World exports in 2024
$3.81B
+10.3% vs 2023, imports $7.05B
2019 to 2024
Top exporters
  1. China28.9%
  2. Switzerland * partner reported12.7%
  3. Germany7.8%
Top importers
  1. United States49.7%
  2. China11.9%
  3. India * partner reported3.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Nabilone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Nabilone, based on the data on this page

What is Nabilone?

Nabilone is a synthetic cannabinoid and dibenzopyrane derivative with anti-emetic activity.

What is the CAS number of Nabilone?

The CAS registry number of Nabilone is 51022-71-0. Other or deprecated CAS numbers: 61617-09-2.

What is the molecular formula and weight of Nabilone?

The molecular formula of Nabilone is C24H36O3 and its molar mass is 372.55 g/mol.

What is Nabilone used for?

Known uses and roles of Nabilone include cns agents in pharmaceuticals, anti-anxiety agents and antiemetics.

Is Nabilone hazardous?

Nabilone carries the GHS signal word "Warning". Main hazards: harmful if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Nabilone?

Nabilone is usually classified under HS code 293299 (Heterocyclic compounds with oxygen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Can I buy Nabilone on CompoundList?

No. Nabilone is on our prohibited list, so listings, quotes and messages for it are disabled. This page is kept for information only.

Guides for buyers

Practical guides that help when you source, ship or handle Nabilone

Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page

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