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Hormones and steroids

Nafarelin

Also known as Nafareline, Nafarelina, Nafarelinum

CAS 76932-56-4Formula C66H83N17O13Molar mass 1,322.50 g/molEC 686-425-8
GHS signal word: Danger. Pictograms: Serious health hazard 12 suppliers listed Drug substance
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Nafarelin chemical structure, C66H83N17O13, CAS 76932-56-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
76932-56-4
Formula
C66H83N17O13
Molar mass
1,322.50 g/mol
EC number
686-425-8
HS code
293329
Category
Hormones and steroids

What is Nafarelin?

Plain description, key identifiers and synonyms

Nafarelin is a Gonadotropin Releasing Hormone Receptor Agonist. The mechanism of action of nafarelin is as a Gonadotropin Releasing Hormone Receptor Agonist.

Nafarelin is a pharmaceutical drug.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
CAS number
76932-56-4 CAS number cross-checked
EC number
686-425-8
Molecular formula
C66H83N17O13
UNII
1X0094V6JV
MDL number
MFCD00871253
InChIKey
RWHUEXWOYVBUCI-ITQXDASVSA-N
InChI
InChI=1S/C66H83N17O13/c1-36(2)25-48(58(89)76-47(13-7-23-71-66(68)69)65(96)83-24-8-14-54(83)64(95)73-33-55(67)86)77-60(91)50(28-38-15-18-39-9-3-4-10-40(39)26-38)78-59(90)49(27-37-16-19-43(85)20-17-37)79-63(94)53(34-84)82-61(92)51(29-41-31-72-45-12-6-5-11-44(41)45)80-62(93)52(30-42-32-70-35-74-42)81-57(88)46-21-22-56(87)75-46/h3-6,9-12,15-20,26,31-32,35-36,46-54,72,84-85H,7-8,13-14,21-25,27-30,33-34H2,1-2H3,(H2,67,86)(H,70,74)(H,73,95)(H,75,87)(H,76,89)(H,77,91)(H,78,90)(H,79,94)(H,80,93)(H,81,88)(H,82,92)(H4,68,69,71)/t46-,47-,48-,49-,50+,51-,52-,53-,54-/m0/s1
Canonical SMILES
CC(C)CC(NC(=O)C(Cc1ccc2ccccc2c1)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CO)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(Cc1cnc[nH]1)NC(=O)C1CCC(=O)N1)C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NCC(N)=O
Isomeric SMILES
CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N)NC(=O)[C@@H](CC2=CC3=CC=CC=C3C=C2)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC5=CNC6=CC=CC=C65)NC(=O)[C@H](CC7=CN=CN7)NC(=O)[C@@H]8CCC(=O)N8

Synonyms

  • Nafareline
  • Nafarelina
  • Nafarelinum
  • Lhrh, 6(d-nal(2))
  • 6-D-(2-naphthyl)alanyl-GnRH
  • Nafarelin?
  • LHRH, Ala(2-naphthyl)(6)-
  • 5-Oxopro-his-trp-ser-tyr-d-nal(2)-leu-arg-pro-gly-nh2

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
1,322.50 g/molcalc.
Exact mass
1,321.6356 Dacalc.
LogP (octanol/water)
-1.62calc.
Topological polar surface area
474.6 Ųcalc.
Hydrogen bond donors
16calc.
Hydrogen bond acceptors
15calc.
Rotatable bonds
33calc.
Heavy atoms
96calc.
Rings
8calc.
Aromatic rings
6calc.
Fraction sp3 carbons
0.41calc.
Formal charge
0calc.
Stereocentres
9calc.
Lipinski rule of five
Fails (3 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(CNC(=O)C(Cc1ccc2ccccc2c1)NC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(Cc1cnc[nH]1)NC(=O)C1CCC(=O)N1)NCC(=O)N1CCCC1

O=C(CNC(=O)C(Cc1ccc2ccccc2c1)NC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(Cc1cnc[nH]1)NC(=O)C1CCC(=O)N1)NCC(=O)N1CCCC1

8 rings, 75 atoms.

4 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H360May damage fertility or the unborn child.
Precautionary statements (5)
  • P203Obtain, read and follow all safety instructions before use.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P318If exposed or concerned, get medical advice.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Nafarelin suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 12 suppliers
12 of 12 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

12 suppliers in 4 countries

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Nafarelin price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Fertility Agents, Female

Roles

  • agonist
  • anti-estrogen
  • gonadotropin releasing hormone agonist
  • hormone agonist
  • hormone receptor modulator
  • pharmaceutical
  • receptor modulator

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Nafarelin is traded under.

HS 2933.29Indicative HS code

Compounds containing an unfused imidazole ring (whether or not hydrogenated) in the…

World exports in 2024
$1.43B
−7.6% vs 2023, imports $1.47B
2019 to 2024
Top exporters
  1. China28.1%
  2. France * partner reported12.7%
  3. India * partner reported10.3%
Top importers
  1. United Kingdom13.0%
  2. United States7.9%
  3. China6.5%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Nafarelin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Nafarelin, based on the data on this page

What is Nafarelin?

Nafarelin is a Gonadotropin Releasing Hormone Receptor Agonist. The mechanism of action of nafarelin is as a Gonadotropin Releasing Hormone Receptor Agonist.

What is the CAS number of Nafarelin?

The CAS registry number of Nafarelin is 76932-56-4.

What is the molecular formula and weight of Nafarelin?

The molecular formula of Nafarelin is C66H83N17O13 and its molar mass is 1,322.50 g/mol.

What is Nafarelin used for?

Known uses and roles of Nafarelin include hormones and steroids in pharmaceuticals, agonist, anti-estrogen, gonadotropin releasing hormone agonist, hormone agonist and 4 more.

Is Nafarelin hazardous?

Nafarelin carries the GHS signal word "Danger". Main hazards: may damage fertility or the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Nafarelin?

Nafarelin is usually classified under HS code 293329 (Compounds containing an unfused imidazole ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Nafarelin?

CompoundList lists 12 suppliers of Nafarelin in China, United States, Germany and France. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Nafarelin?

Suppliers quote Nafarelin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Nafarelin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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