CompoundList
Sign in
Analgesics and anti-inflammatories

Naproxen

Also known as (S)-Naproxen, (+)-Naproxen, Equiproxen

CAS 22204-53-1Formula C14H14O3Molar mass 230.26 g/molEC 244-838-7
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant, Serious health hazard 99 suppliers listed Drug substance
Get quotes Compare 99 suppliers
Naproxen chemical structure, C14H14O3, CAS 22204-53-1
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals from acetone-hexane
Melting point
155 °C
Solubility
Soluble in 25 parts ethanol (96%), 20 parts methanol, 15 parts chloroform, 40 parts ethe…
HS code
291899
Category
Analgesics and anti-inflammatories
Illustrative photo, closed jumbo bulk bags in a warehouse in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Naproxen?

Plain description, key identifiers and synonyms

Naproxen is a methoxynaphthalene that is 2-methoxynaphthalene substituted by a carboxy ethyl group at position 6. Naproxen is a non-steroidal anti-inflammatory drug commonly used for the reduction of pain, fever, inflammation and stiffness caused by conditions such as osteoarthritis, kidney stones, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis, menstrual cramps, tendinitis, bursitis, and for the treatment of primary dysmenorrhea. It works by inhibiting both the COX-1 and COX-2 enzymes. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antipyretic, a xenobiotic, a gout suppressant, a cyclooxygenase 2 inhibitor, a cyclooxygenase 1 inhibitor, an environmental contaminant and a drug allergen. It is a monocarboxylic acid and a methoxynaphthalene. It is a conjugate acid of a naproxen(1-).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid
CAS number
22204-53-1 CAS number cross-checkedOther or deprecated CAS: 131991-52-1
EC number
244-838-7
Molecular formula
C14H14O3
UNII
57Y76R9ATQ
MDL number
MFCD00010500
INCI name
NAPROXEN
InChIKey
CMWTZPSULFXXJA-VIFPVBQESA-N
InChI
InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)/t9-/m0/s1
Canonical SMILES
COc1ccc2cc(C(C)C(=O)O)ccc2c1
Isomeric SMILES
C[C@@H](C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O

Synonyms

  • (S)-Naproxen
  • (+)-Naproxen
  • Equiproxen
  • Naprosyn
  • Naproxene
  • (S)-(+)-Naproxen
  • d-Naproxen
  • Nycopren
  • Naixan
  • Ec-Naprosyn
  • (+)-(S)-Naproxen
  • (2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid
  • (S)-(+)-2-(6-Methoxy-2-naphthyl)propionic acid
  • Laraflex
  • Naprosyne
  • Naproxeno
  • Naproxenum
  • Calosen
  • Naprius
  • Reuxen
  • Bonyl
  • Naxen
  • Axer
  • Veradol
  • Xenar
Show all 39 synonyms
  • Dysmenalgit N
  • Napren E
  • (S)-2-(6-Methoxy-2-naphthyl)propionic acid
  • (S)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid
  • (+)-2-(6-Methoxy-2-naphthyl)propionic acid
  • (+)-2-(Methoxy-2-naphthyl)-propionic acid
  • d-2-(6-Methoxy-2-naphthyl)propionic acid
  • (+)-2-(Methoxy-2-naphthyl)-propionsaeure
  • (S)-2-(6-Methoxy-2-naphthyl)propanoic acid
  • CG 3117
  • (+)-(S)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid
  • (+)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid
  • 2-Naphthaleneacetic acid, 6-methoxy-alpha-methyl-, (+)-
  • Pn400 component naproxen

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystals from acetone-hexaneexp.
Odour
Practically odorlessexp.
Melting point
155 °Cexp.
Solubility
Soluble in 25 parts ethanol (96%), 20 parts methanol, 15 parts chloroform, 40 parts ether. Practically insoluble in waterexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
230.26 g/molcalc.
Exact mass
230.0943 Dacalc.
LogP (octanol/water)
3.04calc.
Topological polar surface area
46.53 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
3calc.
Heavy atoms
17calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.21calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2ccccc2c1

c1ccc2ccccc2c1

2 rings, 10 atoms, the Naphthalene ring system.

17,920 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H301Toxic if swallowed.
  • H302Harmful if swallowed.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
  • H361Suspected of damaging fertility or the unborn child.
Precautionary statements (22)
  • P203Obtain, read and follow all safety instructions before use.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Naproxen suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 99 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

99 suppliers in 16 countries

Send one request to many suppliers

Choose up to 10 suppliers or let us match your request. Compare quotes side by side, free.

Choose suppliersPost a request

Naproxen price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

Get latest price

Uses and applications

What the substance is used for, by industry and function

Anti-inflammatory agent with analgesic and antipyretic properties. Both the acid and sodium salt are used to treat rheumatoid arthritis and other musculoskeletal disorders, dysmmenorrhea, and acute gout.

Non-steroidal anti-inflammatory drug.

Therapeutic category: Anti-inflammatory, analgesic, antipyretic.

Therapeutic category (veterinary): Anti-inflammatory.

Use classes: Pharmaceuticals, Animal Drugs.

Cosmetic ingredient, INCI name NAPROXEN(skin conditioning)

Pharmacological actions

  • Anti-Inflammatory Agents, Non-Steroidal
  • Cyclooxygenase Inhibitors
  • Gout Suppressants

Roles

  • aetiopathogenetic role
  • allergen
  • analgesic
  • anti-inflammatory agent
  • anti-inflammatory drug
  • anti-ulcer drug
  • antimicrobial agent
  • antineoplastic agent
  • antipyretic
  • antirheumatic drug
  • antiviral agent
  • cyclooxygenase 1 inhibitor
  • cyclooxygenase 2 inhibitor
  • drug allergen
  • environmental contaminant
  • enzyme inhibitor
  • gout suppressant
  • immunomodulator
  • immunosuppressive agent
  • non-narcotic analgesic
  • non-steroidal anti-inflammatory drug
  • pharmaceutical
  • vulnerary
  • xenobiotic

Functional uses

  • Pharmaceutical
  • Softener and conditioner

Cosmetic functions

  • Skin conditioning

Pharmacology

Naproxen is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of naproxen is as a Cyclooxygenase Inhibitor.

How it is made

Three consecutive (phase transfer catalysis) reactions (esterification, C-alkylation, and hydrolysis) are used to convert phenylacetic acid derivatives to compounds such as ibuprofen and naproxen.

The major pharmaceutical products based on 2-naphthol (include) ... the antirheumatic naproxen, produced via 2-methoxynaphthalene.

Naproxen, an antirheumatic, is ... prepared from 2-naphthol by the Friedel-Crafts acylation of 2-methoxynaphthalene and subsequent Willgerodt-Kindler reaction. The S-configuration which is obtained from its racemic mixture with the alkaloid cinchonidine is the effective isomer.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory
  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Naproxen is traded under.

HS 2918.99Indicative HS code

Carboxylic acids, with additional oxygen function (not alcohol, phenol, aldehyde or ketone)…

World exports in 2024
$1.46B
−1.1% vs 2023, imports $1.54B
2019 to 2024
Top exporters
  1. China40.0%
  2. India * partner reported26.6%
  3. Germany8.0%
Top importers
  1. United States25.6%
  2. Brazil6.7%
  3. Argentina5.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Naproxen is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Naproxen, based on the data on this page

What is Naproxen?

Naproxen is a methoxynaphthalene that is 2-methoxynaphthalene substituted by a carboxy ethyl group at position 6.

What is the CAS number of Naproxen?

The CAS registry number of Naproxen is 22204-53-1. Other or deprecated CAS numbers: 131991-52-1.

What is the molecular formula and weight of Naproxen?

The molecular formula of Naproxen is C14H14O3 and its molar mass is 230.26 g/mol.

What is Naproxen used for?

Anti-inflammatory agent with analgesic and antipyretic properties. Both the acid and sodium salt are used to treat rheumatoid arthritis and other musculoskeletal disorders, dysmmenorrhea, and acute gout. Non-steroidal anti-inflammatory drug. Therapeutic category: Anti-inflammatory, analgesic, antipyretic.

Is Naproxen hazardous?

Naproxen carries the GHS signal word "Danger". Main hazards: toxic if swallowed, harmful if swallowed, causes skin irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Naproxen?

Naproxen is usually classified under HS code 291899 (Carboxylic acids with additional oxygen function and their anhydrides, halides…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Naproxen?

CompoundList lists 99 suppliers of Naproxen in China, United States, Germany, India and 12 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Naproxen in India?

5 suppliers in India list Naproxen on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Naproxen?

Suppliers quote Naproxen on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Naproxen

Get quotes for Naproxen

Post one free request with your grade, quantity and destination. Matching suppliers send quotes you can compare side by side.
Post a request Sell Naproxen
Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
Embed this structure on your websiteShow code

Paste this code into your page to show the 2D structure of Naproxen with a 3D view, its CAS number where known and a link back to this page. Free to use with the link kept.

<iframe src="https://www.compoundlist.com/embed/structure/naproxen-22204-53-1" title="Naproxen structure on CompoundList" width="360" height="420" style="border:1px solid #E7E2DA;border-radius:12px;max-width:100%" loading="lazy" referrerpolicy="strict-origin-when-cross-origin"></iframe>
Preview the embed

Explore more in Analgesics and anti-inflammatories or HS code 291899

99 suppliers
Free quotes, contact stays private
Get quotes