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Heterocyclic building blocks

(±)-Kawain

Also known as DL-Kavain, 5,6-Dihydro-4-methoxy-6-[(1E)-2-phenylethenyl]-2H-pyran-2-one, 5,6-Dihydro-4-methoxy-6-((1E)-2-phenylethenyl)-2H-pyran-2-one

CAS 3155-48-4Formula C14H14O3Molar mass 230.26 g/molEC 626-921-3
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant, Hazardous to the environment 6 suppliers listed
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(±)-Kawain chemical structure, C14H14O3, CAS 3155-48-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
3155-48-4
Formula
C14H14O3
Molar mass
230.26 g/mol
EC number
626-921-3
HS code
293220
Category
Heterocyclic building blocks

What is (±)-Kawain?

Plain description, key identifiers and synonyms

DL-kavain is https://www.chemicalbook.com/ProductChemicalPropertiesCB9738874_EN.htm. It has a role as a glycine receptor antagonist.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-methoxy-2-[(E)-2-phenylethenyl]-2,3-dihydropyran-6-one
CAS number
3155-48-4 CAS number cross-checkedOther or deprecated CAS: 1635-33-2
EC number
626-921-3
Molecular formula
C14H14O3
UNII
5L1NI60TGB
MDL number
MFCD00270446
InChIKey
XEAQIWGXBXCYFX-BQYQJAHWSA-N
InChI
InChI=1S/C14H14O3/c1-16-13-9-12(17-14(15)10-13)8-7-11-5-3-2-4-6-11/h2-8,10,12H,9H2,1H3/b8-7+
Canonical SMILES
COC1=CC(=O)OC(C=Cc2ccccc2)C1
Isomeric SMILES
COC1=CC(=O)OC(C1)/C=C/C2=CC=CC=C2

Synonyms

  • DL-Kavain
  • 5,6-Dihydro-4-methoxy-6-[(1E)-2-phenylethenyl]-2H-pyran-2-one
  • 5,6-Dihydro-4-methoxy-6-((1E)-2-phenylethenyl)-2H-pyran-2-one
  • Kawain, (+-)-
  • DL-Kawain
  • Neuronica
  • Kavain, dl-
  • rac-Kavain
  • (+/-)-Kavain
  • (+/-)-kawain
  • (E)-4-methoxy-6-styryl-5,6-dihydro-2H-pyran-2-one
  • d,l-Kawain
  • 2H-Pyran-2-one, 5,6-dihydro-4-methoxy-6-[(1E)-2-phenylethenyl]-
  • 4-methoxy-2-[(E)-2-phenylethenyl]-2,3-dihydropyran-6-one
  • 4-Methoxy-6-styryl-5,6-dihydro-2H-pyran-2-one
  • 2H-Pyran-2-one, 5,6-dihydro-4-methoxy-6-(2-phenylethenyl)-
  • 4-Methoxy-6-[(E)-2-phenylvinyl]-5,6-dihydro-2H-pyran-2-one
  • 4-methoxy-6-[(1E)-2-phenylethenyl]-5,6-dihydro-2H-pyran-2-one
  • 2H-Pyran-2-one, 5,6-dihydro-4-methoxy-6-(2-phenylethenyl)-, (E)-(+-)-
  • D,L-Kawin
  • Kawain, DL-
  • trans-5,6-Dihydro-4-methoxy-6-(2-phenylethenyl)-2H-pyran-2-one
  • Kawain (+-)-form
  • KavainDL-Kavain
  • 4-methoxy-6-(2-phenylethenyl)-5,6-dihydro-2h-pyran-2-one
Show all 37 synonyms
  • 2H-Pyran-2-one, 5,6-dihydro-4-methoxy-6-((1E)-2-phenylethenyl)-
  • Kavain (Standard)
  • (+-)-kavain
  • (+-)-kawain
  • 2H-Pyran-2-one, 5,6-dihydro-4-methoxy-6-styryl-
  • DL-Kavain, analytical standard
  • Kawain, (+/-)-
  • 2,6-Heptadienoic acid, 5-hydroxy-3-methoxy-7-phenyl-, delta-lactone
  • Kawain (+/-)-form
  • 4-methoxy-6-styryl-5,6-dihydro-pyran-2-one
  • 4-methoxy-2-[(E)-styryl]-2,3-dihydropyran-6-one
  • DL-Kavain, primary pharmaceutical reference standard

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
230.26 g/molcalc.
Exact mass
230.0943 Dacalc.
LogP (octanol/water)
2.55calc.
Topological polar surface area
35.53 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
3calc.
Heavy atoms
17calc.
Rings
2calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.21calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1C=CCC(C=Cc2ccccc2)O1

O=C1C=CCC(C=Cc2ccccc2)O1

2 rings, 15 atoms.

17 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H302Harmful if swallowed.
  • H311Toxic in contact with skin.
  • H315Causes skin irritation.
  • H331Toxic if inhaled.
  • H332Harmful if inhaled.
  • H400Very toxic to aquatic life.
Precautionary statements (21)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P262Do not get in eyes, on skin, or on clothing.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P316Get emergency medical help immediately.
  • P317Get medical help.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P361 + P364Take off immediately all contaminated clothing. And wash it before reuse.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P391Collect spillage.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

(±)-Kawain suppliers

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All 6 suppliers
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Where suppliers are based

6 suppliers in 4 countries

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(±)-Kawain price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antagonist
  • glycine receptor antagonist

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code (±)-Kawain is traded under.

HS 2932.20Indicative HS code

Lactones

World exports in 2024
$1.97B
−4.7% vs 2023, imports $2.07B
2019 to 2024
Top exporters
  1. China56.3%
  2. India * partner reported7.4%
  3. Germany7.3%
Top importers
  1. United States14.2%
  2. India * partner reported13.5%
  3. Brazil8.5%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for (±)-Kawain is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about (±)-Kawain, based on the data on this page

What is (±)-Kawain?

DL-kavain is https://www.chemicalbook.com/ProductChemicalPropertiesCB9738874_EN.htm. It has a role as a glycine receptor antagonist.

What is the CAS number of (±)-Kawain?

The CAS registry number of (±)-Kawain is 3155-48-4. Other or deprecated CAS numbers: 1635-33-2.

What is the molecular formula and weight of (±)-Kawain?

The molecular formula of (±)-Kawain is C14H14O3 and its molar mass is 230.26 g/mol.

What is (±)-Kawain used for?

Known uses and roles of (±)-Kawain include building blocks in research and laboratory, screening compounds in research and laboratory, antagonist and glycine receptor antagonist.

Is (±)-Kawain hazardous?

(±)-Kawain carries the GHS signal word "Danger". Main hazards: harmful if swallowed, toxic in contact with skin, causes skin irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of (±)-Kawain?

(±)-Kawain is usually classified under HS code 293220 (Lactones). This is indicative, confirm it with your customs broker before shipping.

Where can I buy (±)-Kawain?

CompoundList lists 6 suppliers of (±)-Kawain in China, France, Japan and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of (±)-Kawain?

Suppliers quote (±)-Kawain on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle (±)-Kawain

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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