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Impurities and reference standards

Naproxen methyl ester

Also known as (S)-Naproxen Methyl Ester, Methyl (2S)-2-(6-methoxynaphthalen-2-yl)propanoate, (+)-Naproxen Methyl Ester

CAS 26159-35-3Formula C15H16O3Molar mass 244.29 g/molEC 641-911-9
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant, Serious health hazard, Hazardous to the environment 1 supplier listed
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Naproxen methyl ester chemical structure, C15H16O3, CAS 26159-35-3
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
26159-35-3
Formula
C15H16O3
Molar mass
244.29 g/mol
EC number
641-911-9
HS code
291899
Category
Impurities and reference standards

What is Naproxen methyl ester?

Plain description, key identifiers and synonyms

Naproxen methyl ester is a chemical substance with the molecular formula C15H16O3 and a molar mass of 244.29 g/mol. Its CAS registry number is 26159-35-3. The IUPAC name is methyl (2S)-2-(6-methoxynaphthalen-2-yl)propanoate.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
methyl (2S)-2-(6-methoxynaphthalen-2-yl)propanoate
CAS number
26159-35-3 CAS number cross-checked
EC number
641-911-9
Molecular formula
C15H16O3
UNII
571OJX4PDN
MDL number
MFCD12031841
InChIKey
ZFYFBPCRUQZGJE-JTQLQIEISA-N
InChI
InChI=1S/C15H16O3/c1-10(15(16)18-3)11-4-5-13-9-14(17-2)7-6-12(13)8-11/h4-10H,1-3H3/t10-/m0/s1
Canonical SMILES
COC(=O)C(C)c1ccc2cc(OC)ccc2c1
Isomeric SMILES
C[C@@H](C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)OC

Synonyms

  • (S)-Naproxen Methyl Ester
  • Methyl (2S)-2-(6-methoxynaphthalen-2-yl)propanoate
  • (+)-Naproxen Methyl Ester
  • Naproxen impurity E
  • 2-Naphthaleneacetic acid, 6-methoxy-alpha-methyl-, methyl ester, (alphaS)-
  • Naproxen sodium impurity E
  • 2-Naphthaleneacetic acid, 6-methoxy-alpha-methyl-, methyl ester, (.alpha.s)-
  • Naproxen impurity e (ep impurity)
  • Naproxen sodium impurity e (ep impurity)
  • (S)-Methyl 2-(6-methoxynaphthalen-2-yl)propanoate
  • Naproxen EP Impurity E
  • Methyl (S)-2-(6-Methoxynaphthalen-2-yl)propanoate
  • (S)-Methyl2-(6-methoxynaphthalen-2-yl)propanoate
  • Methyl (2S)-2-(6-Methoxynaphthalen-2-yl)propanoate (Naproxen Methyl Ester)
  • Monomethyl derivative of Naproxen
  • Methyl (2S)-2-(6-Methoxynaphthalen-2-yl)propanoate, Naproxen Imp. E (EP), Naproxen Methyl Ester, Naproxen Impurity E
  • Naproxen Impurity 28
  • Naproxen methyl derivative
  • (r,s)-naproxen methyl ester
  • (+)-Napr oxen methyl ester
  • (S)-alpha-methyl-6-methoxy-2-naphthaleneacetic acid methyl ester
  • Methyl 2-(6-methoxy-2-naphthyl)propanoate #
  • methyl (2S)-2-(6-methoxy-2-naphthyl)propanoate
  • (S)-Naproxen methyl ester, pharmaceutical impurity standard
  • (a-S)-6-Methoxy-a-methyl-2-naphthaleneacetic acid methyl ester
Show all 29 synonyms
  • (S)-6-Methoxy-a-methyl-2-naphthaleneacetic acid methyl ester
  • 2-Naphthaleneacetic acid, 6-methoxy-alpha-methyl-, methyl ester
  • 2-Naphthaleneacetic acid, 6-methoxy-|A-methyl-, methyl ester, (|AS)-
  • RXH

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
244.29 g/molcalc.
Exact mass
244.1099 Dacalc.
LogP (octanol/water)
3.12calc.
Topological polar surface area
35.53 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
3calc.
Heavy atoms
18calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.27calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2ccccc2c1

c1ccc2ccccc2c1

2 rings, 10 atoms, the Naphthalene ring system.

17,920 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H301Toxic if swallowed.
  • H302Harmful if swallowed.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
  • H360May damage fertility or the unborn child.
  • H361fdSuspected of damaging fertility. Suspected of damaging the unborn child.
  • H411Toxic to aquatic life with long lasting effects.
Precautionary statements (24)
  • P203Obtain, read and follow all safety instructions before use.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P391Collect spillage.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Naproxen methyl ester suppliers

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Naproxen methyl ester price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Applications are not documented for this substance yet. Suppliers often describe uses on their product pages, linked in the suppliers list above.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Naproxen methyl ester is traded under.

HS 2918.99Indicative HS code

Carboxylic acids, with additional oxygen function (not alcohol, phenol, aldehyde or ketone)…

World exports in 2024
$1.46B
−1.1% vs 2023, imports $1.54B
2019 to 2024
Top exporters
  1. China40.0%
  2. India * partner reported26.6%
  3. Germany8.0%
Top importers
  1. United States25.6%
  2. Brazil6.7%
  3. Argentina5.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Naproxen methyl ester is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Naproxen methyl ester, based on the data on this page

What is Naproxen methyl ester?

Naproxen methyl ester is a chemical substance with the molecular formula C15H16O3 and a molar mass of 244.29 g/mol. Its CAS registry number is 26159-35-3. The IUPAC name is methyl (2S)-2-(6-methoxynaphthalen-2-yl)propanoate.

What is the CAS number of Naproxen methyl ester?

The CAS registry number of Naproxen methyl ester is 26159-35-3.

What is the molecular formula and weight of Naproxen methyl ester?

The molecular formula of Naproxen methyl ester is C15H16O3 and its molar mass is 244.29 g/mol.

Is Naproxen methyl ester hazardous?

Naproxen methyl ester carries the GHS signal word "Danger". Main hazards: toxic if swallowed, harmful if swallowed, causes skin irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Naproxen methyl ester?

Naproxen methyl ester is usually classified under HS code 291899 (Carboxylic acids with additional oxygen function and their anhydrides, halides…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Naproxen methyl ester?

CompoundList lists 1 supplier of Naproxen methyl ester in China. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Naproxen methyl ester?

Suppliers quote Naproxen methyl ester on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Naproxen methyl ester

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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