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Vitamins and nutraceutical actives

Nicotinamide

Also known as niacinamide, 3-Pyridinecarboxamide, pyridine-3-carboxamide

CAS 98-92-0Formula C6H6N2OMolar mass 122.13 g/molEC 202-713-4
GHS signal word: Warning. Pictograms: Harmful or irritant 318 suppliers listed Drug substance
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Nicotinamide chemical structure, C6H6N2O, CAS 98-92-0
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
White, powder, needles from benzene
Melting point
128.8 °C
Boiling point
157 °C
Density
1.400 g/cm³ at 25 °C
Flash point
182 °C
HS code
293629
Category
Vitamins and nutraceutical actives
Illustrative photo, fine white powder in a clear glass bottle on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Nicotinamide?

Plain description, key identifiers and synonyms

Nicotinamide is a pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group. It has a role as a geroprotector, an antioxidant, a cofactor, a metabolite, an EC 3.5.1.98 (histone deacetylase) inhibitor, an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor, a neuroprotective agent, an anti-inflammatory agent, a Sir2 inhibitor, a mouse metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a human urinary metabolite. It is a vitamin B3, a pyridinecarboxamide and a pyridine alkaloid. It is functionally related to a nicotinic acid.

Nicotinamide is a chemical compound: amide form of vitamin B3.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
pyridine-3-carboxamide
CAS number
98-92-0 CAS number cross-checkedOther or deprecated CAS: 11032-50-1, 1255150-40-3
EC numbers
202-713-4, 234-265-0
Molecular formula
C6H6N2O
UNII
25X51I8RD4
MDL number
MFCD00006395
INCI name
NIACINAMIDE
InChIKey
DFPAKSUCGFBDDF-UHFFFAOYSA-N
InChI
InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)
SMILES (canonical and isomeric)
C1=CC(=CN=C1)C(=O)N

Synonyms

  • niacinamide
  • 3-Pyridinecarboxamide
  • pyridine-3-carboxamide
  • Nicotinic acid amide
  • Aminicotin
  • Amixicotyn
  • Benicot
  • Dipegyl
  • Nicofort
  • Papulex
  • Nicotinic amide
  • Delonin amide
  • Pelonin amide
  • Inovitan PP
  • Nicotilamide
  • Nicotylamide
  • Endobion
  • Hansamid
  • Nicamindon
  • Nicobion
  • Nicovitol
  • Nikotinamid
  • Niozymin
  • Savacotyl
  • Pelmine
Show all 39 synonyms
  • 3-Carbamoylpyridine
  • Austrovit PP
  • Vi-Nicotyl
  • Amnicotin
  • Nicomidol
  • Nicosylamide
  • Nicotamide
  • Nicotililamido
  • Nicovitina
  • Nicozymin
  • Niocinamide
  • Niacevit
  • Niamide
  • Nicamina

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
White, powder, needles from benzeneexp.
Odour
Odorlessexp.
Taste
Bitter tasteexp.
Melting point
128.8 °Cexp.
Boiling point
157 °Cexp.
Density
1.400 g/cm³ at 25 °Cexp.
Flash point
182 °Cexp.
Autoignition temperature
480 °Cexp.
Solubility
In water, 5 × 10⁺⁵ mg/L at 25 °Cexp.
Vapour pressure
Vapor pressure, kPa at 35 °C: 3.1exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
122.13 g/molcalc.
Exact mass
122.048 Dacalc.
LogP (octanol/water)
0.18calc.
Topological polar surface area
55.98 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
1calc.
Heavy atoms
9calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccncc1

c1ccncc1

1 ring, 6 atoms, the Pyridine ring system.

118,162 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (16)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Nicotinamide suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 318 suppliers
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

318 suppliers in 40 countries

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Nicotinamide price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Vitamin B Complex.

Nicotinamide is ... used in cosmetics as hair and skin conditioning agent.

/Has/ been used in the enrichment of bread, flour, and other grain-derived products. Animal feed is routinely supplemented with ... nicotinamide. Nicotinamide is also used in multivitamin preparations.

Veterinary medication:.

Industrial uses: Brightener, Intermediate, Flavoring and nutrient.

Consumer uses: Flavoring and nutrient.

Use classes: Cosmetics.

Cosmetic ingredient, INCI name NIACINAMIDE(smoothing)

Pharmacological actions

  • Vitamin B Complex

Roles

  • Escherichia coli metabolite
  • Saccharomyces cerevisiae metabolite
  • Sir2 inhibitor
  • anti-anaemic agent
  • anti-inflammatory agent
  • antidepressant
  • antiglaucoma drug
  • antineoplastic agent
  • antioxidant
  • antipsoriatic
  • central nervous system drug
  • cofactor
  • dermatologic drug
  • geroprotector
  • human urinary metabolite
  • immunomodulator
  • immunosuppressive agent
  • metabolite
  • mouse metabolite
  • neuroprotective agent
  • ophthalmology drug
  • pharmaceutical
  • protective agent
  • renoprotective agent

Functional uses

  • Flavouring and nutrient
  • Humectant
  • Softener and conditioner

Cosmetic functions

  • Smoothing

Pharmacology

Niacinamide is the active form of vitamin B3 and a component of the coenzyme nicotinamide adenine dinucleotide (NAD). Niacinamide acts as a chemo- and radio-sensitizing agent by enhancing tumor blood flow, thereby reducing tumor hypoxia. This agent also inhibits poly(ADP-ribose) polymerases, enzymes involved in the rejoining of DNA strand breaks induced by radiation or chemotherapy.

How it is made

2-Methylglutaronitrile, a byproduct of adiponitrile production, is converted to 2-methyl-1,5-diaminopentane. Cyclic hydrogenation gives 3-methylpiperidine. Dehydrogenation yields 3-methylpyridine, which is then ammoxidated and partly hydrolyzed to nicotinamide.

In a multitubular reactor 3-methylpyridine, air, ammonia, and hydrogen react at ca. 350 °C and moderate pressure to give 3-cyanopyridine. Heterogeneous catalysts containing oxides of antimony, vanadium, and titanium, antimony, vanadium, and uranium or antimony-vanadium-titanium catalyst are highly effective.

Read more

For instance, with a vanadium, titanium, zirconium, molybdenum catalyst, a reactor temperature of 340 °C, and a molar feed ratio of 3-methylpyridine:ammonia: oxygen of 1:1.3:40 yields 95% of 3-cyanopyridine. 3-Cyanopyridine is converted to nicotinamide by alkaline hydrolysis. This reaction has the advantage that saponification to the amide is fast compared to total hydrolysis to nicotinic acid. The hydrolysis to the amide is normally carried out with catalytic amounts of bases, mainly sodium hydroxide, at 130-150 °C.

In the Lonza process, 3-cyanopyridine is converted to nicotinamide by means of an immobilized microorganism of the genus Rhodococcus. Heterogeneous catalysts are also mentioned. A copper-chromium oxide catalyst, manganese dioxide, or manganese dioxide with chromium-nickel oxide, chromium-cobalt oxide, or manganese dioxide with titanium-silicon dioxide give good yields of nicotinamide.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory
  • Active ingredient in FDA approved drug labels

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Nicotinamide is traded under.

HS 2936.29Indicative HS code

Vitamins and their derivatives, unmixed, other vitamins and their derivatives

World exports in 2024
$2.21B
+8.7% vs 2023, imports $1.85B
2019 to 2024
Top exporters
  1. China25.3%
  2. United States14.5%
  3. Australia13.8%
Top importers
  1. United States16.4%
  2. Netherlands9.4%
  3. Spain5.6%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Nicotinamide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Nicotinamide, based on the data on this page

What is Nicotinamide?

Nicotinamide is a pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.

What is the CAS number of Nicotinamide?

The CAS registry number of Nicotinamide is 98-92-0. Other or deprecated CAS numbers: 11032-50-1, 1255150-40-3.

What is the molecular formula and weight of Nicotinamide?

The molecular formula of Nicotinamide is C6H6N2O and its molar mass is 122.13 g/mol.

What is Nicotinamide used for?

Vitamin B Complex. Nicotinamide is ... used in cosmetics as hair and skin conditioning agent. /Has/ been used in the enrichment of bread, flour, and other grain-derived products. Animal feed is routinely supplemented with ... nicotinamide. Nicotinamide is also used in multivitamin preparations. Veterinary medication:.

Is Nicotinamide hazardous?

Nicotinamide carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation, may cause respiratory irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Nicotinamide?

Nicotinamide is usually classified under HS code 293629 (Vitamins and their derivatives, unmixed, other vitamins and their derivatives). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Nicotinamide?

CompoundList lists 318 suppliers of Nicotinamide in China, India, United States, Germany and 36 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Nicotinamide in India?

57 suppliers in India list Nicotinamide on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Nicotinamide?

Suppliers quote Nicotinamide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Nicotinamide

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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