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Vitamins and nutraceutical actives

Nicotinic acid

Also known as niacin, Pyridine-3-carboxylic acid, 3-pyridinecarboxylic acid

CAS 59-67-6Formula C6H5NO2Molar mass 123.11 g/molEC 200-441-0
GHS signal word: Warning. Pictograms: Harmful or irritant 244 suppliers listed Drug substance
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Nicotinic acid chemical structure, C6H5NO2, CAS 59-67-6
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Needles from alcohol or water
Melting point
237 °C
Boiling point
Sublimes
Density
1.473 g/cm³ at 25 °C
Flash point
193 °C
HS code
293979
Category
Vitamins and nutraceutical actives
Illustrative photo, assorted laboratory chemical bottles and jars on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Nicotinic acid?

Plain description, key identifiers and synonyms

Nicotinic acid is a pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group. It has a role as a metabolite, a vasodilator agent, an antilipemic drug, an antidote, a mouse metabolite, a plant metabolite, an Escherichia coli metabolite, a human urinary metabolite and an EC 3.5.1.19 (nicotinamidase) inhibitor. It is a vitamin B3, a pyridine alkaloid and a pyridinemonocarboxylic acid. It is a conjugate acid of a nicotinate.

Nicotinic acid is a chemical compound: acid form of vitamin B3.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
pyridine-3-carboxylic acid
CAS number
59-67-6 CAS number cross-checkedOther or deprecated CAS: 101113-41-1
EC numbers
200-441-0, 681-634-0
Molecular formula
C6H5NO2
UNII
2679MF687A
MDL number
MFCD00006391
INCI name
NIACIN
InChIKey
PVNIIMVLHYAWGP-UHFFFAOYSA-N
InChI
InChI=1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)
SMILES (canonical and isomeric)
C1=CC(=CN=C1)C(=O)O

Synonyms

  • niacin
  • Pyridine-3-carboxylic acid
  • 3-pyridinecarboxylic acid
  • 3-Carboxypyridine
  • Akotin
  • wampocap
  • Apelagrin
  • Pellagrin
  • Daskil
  • Efacin
  • Niaspan
  • Pelonin
  • Linic
  • Nicyl
  • nicolar
  • Nicotinipca
  • Nicacid
  • Nicangin
  • Niconacid
  • Diacin
  • Nyclin
  • Acidum nicotinicum
  • nicamin
  • Vitaplex N
  • Nico-Span
Show all 39 synonyms
  • Direktan
  • Nicodelmine
  • Nicovasen
  • Pellagramin
  • Bionic
  • Naotin
  • Peviton
  • Niac
  • vitamin B3
  • Nicosan 3
  • Davitamon PP
  • nicobid
  • nicocap
  • Tega-Span

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Needles from alcohol or waterexp.
Odour
Odorlessexp.
Taste
Sour tasteexp.
Melting point
237 °Cexp.
Boiling point
Sublimesexp.
Density
1.473 g/cm³ at 25 °Cexp.
Flash point
193 °Cexp.
Autoignition temperature
580 °Cexp.
Solubility
In water, 1.8 × 10⁺⁴ mg/L at 20 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
123.11 g/molcalc.
Exact mass
123.032 Dacalc.
LogP (octanol/water)
0.78calc.
Topological polar surface area
50.19 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
1calc.
Heavy atoms
9calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccncc1

c1ccncc1

1 ring, 6 atoms, the Pyridine ring system.

118,162 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H319Causes serious eye irritation.
Precautionary statements (4)
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P337 + P317If eye irritation persists: Get medical help.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Nicotinic acid suppliers

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All 244 suppliers
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Where suppliers are based

244 suppliers in 32 countries

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Nicotinic acid price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Hypolipidemic Agents, Vasodilator Agents, Vitamin B Complex.

Medicine (cholesterol-lowering agent), nutrition, feeds, enriched flours, dietary supplement.

/Has/ been used in the enrichment of bread, flour, and other grain-derived products. Animal feed is routinely supplemented with nicotinic acid...

Industrial uses: Flavoring and nutrient, Intermediate.

Consumer uses: Flavoring and nutrient.

Use classes: Cosmetics.

Cosmetic ingredient, INCI name NIACIN(antistatic, smoothing)

Pharmacological actions

  • Hypolipidemic Agents
  • Vasodilator Agents
  • Vitamin B Complex

Roles

  • Escherichia coli metabolite
  • analgesic
  • anti-HIV agent
  • anti-anaemic agent
  • anti-obesity agent
  • antiatherosclerotic agent
  • anticholesteremic drug
  • antidepressant
  • antidote
  • antilipemic drug
  • antimicrobial drug
  • antineoplastic agent
  • antipsychotic agent
  • antitubercular agent
  • anxiolytic drug
  • cardiovascular drug
  • human urinary metabolite
  • hypoglycemic agent
  • metabolite
  • mouse metabolite
  • pharmaceutical
  • plant metabolite
  • renoprotective agent
  • vasodilator agent

Functional uses

  • Anti-static agent
  • Flavouring and nutrient
  • Humectant
  • Softener and conditioner

Cosmetic functions

  • Antistatic
  • Smoothing

Pharmacology

Niacin is a Nicotinic Acid.

How it is made

In an aqueous solution 5-ethyl-2-methylpyridine is oxidized to nicotinic acid in a single-tube reactor by using an excess of nitric acid. The continuous process takes place at 230-270 °C and 6-8 MPa. Pyridine-2,5-dicarboxylic acid is formed as an intermediate, but is not stable under the reaction conditions, undergoing decarboxylation to nicotinic acid nitrate. Neutralization of the nitrate with 5-ethyl-2-methylpyridine yields nicotinic acid. Water and carbon dioxide formed in the reaction are separated from the product. The nitrogen oxide formed is oxidized with air to nitrogen dioxide and then absorbed in water to yield nitric acid, which is recycled into the process.

Preparation by oxidation of alkyl beta-substituted pyridines

Preparation by oxidation of nicotine

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory
  • Active ingredient in FDA approved drug labels

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Nicotinic acid is traded under.

HS 2939.79Indicative HS code

Alkaloids of vegetal origin, other than cocaine, ecgonine, salts, esters and other derivatives, not elsewhere…

World exports in 2024
$701M
+18.9% vs 2023, imports $830M
2019 to 2024
Top exporters
  1. Switzerland * partner reported25.3%
  2. Germany21.4%
  3. India * partner reported14.9%
Top importers
  1. United States20.9%
  2. Germany14.7%
  3. Italy14.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Nicotinic acid is indicative (it is known at chapter level only). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Nicotinic acid, based on the data on this page

What is Nicotinic acid?

Nicotinic acid is a pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group.

What is the CAS number of Nicotinic acid?

The CAS registry number of Nicotinic acid is 59-67-6. Other or deprecated CAS numbers: 101113-41-1.

What is the molecular formula and weight of Nicotinic acid?

The molecular formula of Nicotinic acid is C6H5NO2 and its molar mass is 123.11 g/mol.

What is Nicotinic acid used for?

Hypolipidemic Agents, Vasodilator Agents, Vitamin B Complex. Medicine (cholesterol-lowering agent), nutrition, feeds, enriched flours, dietary supplement. /Has/ been used in the enrichment of bread, flour, and other grain-derived products. Animal feed is routinely supplemented with nicotinic acid...

Is Nicotinic acid hazardous?

Nicotinic acid carries the GHS signal word "Warning". Main hazards: causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Nicotinic acid?

Nicotinic acid is usually classified under HS code 293979 (Alkaloids, natural or reproduced by synthesis, and their salts, ethers, esters and other…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Nicotinic acid?

CompoundList lists 244 suppliers of Nicotinic acid in China, United States, India, Germany and 28 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Nicotinic acid in India?

33 suppliers in India list Nicotinic acid on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Nicotinic acid?

Suppliers quote Nicotinic acid on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Nicotinic acid

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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