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Analgesics and anti-inflammatories

Nitrosulindac

Also known as NCX 1102, NO-Releasing Sulindac, (1Z)-5-Fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic Acid, 4-(Nitrooxy)butyl Ester

CAS 326850-47-9Formula C24H24FNO6SMolar mass 473.52 g/mol
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Nitrosulindac chemical structure, C24H24FNO6S, CAS 326850-47-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
326850-47-9
Formula
C24H24FNO6S
Molar mass
473.52 g/mol
HS code
293090
Category
Analgesics and anti-inflammatories

What is Nitrosulindac?

Plain description, key identifiers and synonyms

Nitrosulindac is a carboxylic ester that is the 4-(nitrooxy)butyl ester of sulindac. A non-steroidal anti-inflammatory drug, which also has anticancer activity. It has a role as a non-steroidal anti-inflammatory drug, an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor, an antineoplastic agent, a prodrug and an apoptosis inducer. It is a sulfoxide, a carboxylic ester, an organofluorine compound and a nitrate ester. It is functionally related to a sulindac. It derives from a hydride of an indene.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-nitrooxybutyl 2-[(3Z)-6-fluoro-2-methyl-3-[(4-methylsulfinylphenyl)methylidene]inden-1-yl]acetate
CAS number
326850-47-9
Molecular formula
C24H24FNO6S
InChIKey
CMZSMYLJISCEDU-BKUYFWCQSA-N
InChI
InChI=1S/C24H24FNO6S/c1-16-21(13-17-5-8-19(9-6-17)33(2)30)20-10-7-18(25)14-23(20)22(16)15-24(27)31-11-3-4-12-32-26(28)29/h5-10,13-14H,3-4,11-12,15H2,1-2H3/b21-13-
Canonical SMILES
CC1=C(CC(=O)OCCCCO[N+](=O)[O-])c2cc(F)ccc2C1=Cc1ccc(S(C)=O)cc1
Isomeric SMILES
CC\1=C(C2=C(/C1=C\C3=CC=C(C=C3)S(=O)C)C=CC(=C2)F)CC(=O)OCCCCO[N+](=O)[O-]

Synonyms

  • NCX 1102
  • NO-Releasing Sulindac
  • (1Z)-5-Fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic Acid, 4-(Nitrooxy)butyl Ester
  • 4-(nitrooxy)butyl {(1Z)-5-fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1H-inden-3-yl}acetate
  • 4-nitrooxybutyl 2-[(3Z)-6-fluoro-2-methyl-3-[(4-methylsulfinylphenyl)methylidene]inden-1-yl]acetate

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
473.52 g/molcalc.
Exact mass
473.1308 Dacalc.
LogP (octanol/water)
4.81calc.
Topological polar surface area
95.74 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
10calc.
Heavy atoms
33calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.29calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1=Cc2ccccc2C1=Cc1ccccc1

C1=Cc2ccccc2C1=Cc1ccccc1

3 rings, 16 atoms.

108 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Nitrosulindac suppliers

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Nitrosulindac price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • anti-inflammatory agent
  • anti-inflammatory drug
  • antineoplastic agent
  • antirheumatic drug
  • apoptosis inducer
  • enzyme inhibitor
  • non-steroidal anti-inflammatory drug
  • pharmaceutical
  • pro-agent
  • prodrug

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Nitrosulindac is traded under.

HS 2930.90Indicative HS code

Organo-sulphur compounds, other

World exports in 2024
$5.83B
+0.1% vs 2023, imports $5.93B
2019 to 2024
Top exporters
  1. China40.7%
  2. United States10.9%
  3. Japan9.3%
Top importers
  1. United States13.3%
  2. Brazil12.6%
  3. China6.6%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Nitrosulindac is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Nitrosulindac, based on the data on this page

What is Nitrosulindac?

Nitrosulindac is a carboxylic ester that is the 4-(nitrooxy)butyl ester of sulindac. A non-steroidal anti-inflammatory drug, which also has anticancer activity.

What is the CAS number of Nitrosulindac?

The CAS registry number of Nitrosulindac is 326850-47-9.

What is the molecular formula and weight of Nitrosulindac?

The molecular formula of Nitrosulindac is C24H24FNO6S and its molar mass is 473.52 g/mol.

What is Nitrosulindac used for?

Known uses and roles of Nitrosulindac include anti-inflammatories in pharmaceuticals, anti-inflammatory agent, anti-inflammatory drug, antineoplastic agent, antirheumatic drug and 6 more.

Is Nitrosulindac hazardous?

No GHS hazard classification for Nitrosulindac is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Nitrosulindac?

Nitrosulindac is usually classified under HS code 293090 (Organo-sulphur compounds, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Nitrosulindac?

Post a free request on CompoundList and suppliers of Nitrosulindac will send you quotes. Your contact details stay private until you accept a quote.

What is the price of Nitrosulindac?

Suppliers quote Nitrosulindac on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Nitrosulindac

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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