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Hormones and steroids

Norgestimate

Also known as Dexnorgestrel acetime, Norgestimato, Norgestimatum

CAS 35189-28-7Formula C23H31NO3Molar mass 369.51 g/molEC 639-446-1
GHS signal word: Danger. Pictograms: Harmful or irritant, Serious health hazard 14 suppliers listed
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Norgestimate chemical structure, C23H31NO3, CAS 35189-28-7
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
35189-28-7
Formula
C23H31NO3
Appearance
Crystals from methylene chloride
Melting point
214 to 218
HS code
293723
Category
Hormones and steroids
Illustrative photo, closed jumbo bulk bags in a warehouse in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Norgestimate?

Plain description, key identifiers and synonyms

Norgestimate is a ketoxime, a steroid ester and a terminal acetylenic compound. It has a role as a contraceptive drug, a synthetic oral contraceptive and a progestin.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
[(3E,8R,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-3-hydroxyimino-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-yl] acetate
CAS number
35189-28-7 CAS number cross-checkedOther or deprecated CAS: 107382-52-5
EC number
639-446-1
Molecular formula
C23H31NO3
UNII
NKX8DN6TY9
MDL number
MFCD00867874
InChIKey
KIQQMECNKUGGKA-NMYWJIRASA-N
InChI
InChI=1S/C23H31NO3/c1-4-22-12-10-19-18-9-7-17(24-26)14-16(18)6-8-20(19)21(22)11-13-23(22,5-2)27-15(3)25/h2,14,18-21,26H,4,6-13H2,1,3H3/b24-17+/t18-,19+,20+,21-,22-,23-/m0/s1
Canonical SMILES
C#CC1(OC(C)=O)CCC2C3CCC4=CC(=NO)CCC4C3CCC21CC
Isomeric SMILES
CC[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C#C)OC(=O)C)CCC4=C/C(=N/O)/CC[C@H]34

Synonyms

  • Dexnorgestrel acetime
  • Norgestimato
  • Norgestimatum
  • ORF 10131
  • RWJ 10131
  • (+)-13-Ethyl-17-hydroxy-18,19-dinor-17alpha-pregn-4-en-20-yn-3-one oxime acetate (ester)
  • (17alpha)-17-(Acetyloxy)-13-ethyl-18,19-dinorpregn-4-en-20-yn-3-one 3-oxime
  • d-13beta-Ethyl-17alpha-ethynyl-17beta-acetoxygon-4-en-3-one oxime
  • (1S,2R,5E,10R,11S,14R,15S)-15-ethyl-14-ethynyl-5-(hydroxyimino)tetracyclo(8.7.0.0^(2,7).0^(11,15))heptadec-6-en-14-yl acetate
  • (1S,2R,5E,10R,11S,14R,15S)-15-ethyl-14-ethynyl-5-(hydroxyimino)tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-14-yl acetate
  • anti-Norgestimate
  • Norgestimate, E-
  • [(3E,8R,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-3-hydroxyimino-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-yl] acetate
  • 18,19-Dinorpregn-4-en-20-yn-3-one, 17-(acetyloxy)-13-ethyl-, 3-oxime, (3E,17alpha)-
  • Norgestimate (USP/INN)
  • dexnorgestrel
  • Norgestimate, >=97% (HPLC)
  • (3E)-17alpha-ethynyl-3-(hydroxyimino)-18a-homoestr-4-en-17beta-yl acetate
  • 18,19-Dinorpregn-4-en-20-yn-3-one, 17-(acetyloxy)-13-ethyl-, 3-oxime, (17alpha)-
  • (1R,3aS,3bR,7E,9aR,9bS,11aS)-11a-Ethyl-1-ethynyl-7-(hydroxyimino)-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[a]phenanthren-1-yl acetate
  • (8R,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-3-(hydroxyimino)-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate
  • 18,19-Dinorpregn-4-en-20-yn-3-one, 17-(acetyloxy)-13-ethyl-, 3-oxime, (3E,17.alpha.)-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystals from methylene chlorideexp.
Melting point
214 to 218exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
369.51 g/molcalc.
Exact mass
369.2304 Dacalc.
LogP (octanol/water)
4.71calc.
Topological polar surface area
58.89 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
2calc.
Heavy atoms
27calc.
Rings
4calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.74calc.
Formal charge
0calc.
Stereocentres
6calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, N=C1C=C2CCC3C4CCCC4CCC3C2CC1

N=C1C=C2CCC3C4CCCC4CCC3C2CC1

4 rings, 18 atoms.

90 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302Harmful if swallowed.
  • H312Harmful in contact with skin.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H332Harmful if inhaled.
  • H351Suspected of causing cancer.
  • H360May damage fertility or the unborn child.
  • H361Suspected of damaging fertility or the unborn child.
  • H362May cause harm to breast-fed children.
Precautionary statements (22)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P263Avoid contact during pregnancy and while nursing.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P317Get medical help.
  • P318If exposed or concerned, get medical advice.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Norgestimate suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 14 suppliers
14 of 14 offers

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Where suppliers are based

14 suppliers in 6 countries

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Norgestimate price

Indicative price range per kg from live supplier offers

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Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Contraceptive Agents, Hormonal
  • Contraceptives, Oral, Synthetic

Roles

  • agonist
  • anti-HIV agent
  • antimicrobial agent
  • antiviral agent
  • bone density conservation agent
  • contraceptive drug
  • female contraceptive drug
  • hormone
  • molecular messenger
  • oral contraceptive
  • pharmaceutical
  • progestin
  • progestogen
  • reproductive control drug
  • sex hormone
  • synthetic oral contraceptive

Pharmacology

Norgestimate is a Progestin.

How it is made

Prepn: A.P. Shroff, D.E. 2633210, U.s. pat. 4027019 (both 1977 to Ortho).

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Norgestimate is traded under.

HS 2937.23Indicative HS code

Oestrogens and progestogens

World exports in 2024
$762M
−2.3% vs 2023, imports $693M
2019 to 2024
Top exporters
  1. China42.9%
  2. Italy18.4%
  3. Netherlands8.9%
Top importers
  1. India * partner reported12.1%
  2. United States11.0%
  3. Belgium8.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Norgestimate is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Norgestimate, based on the data on this page

What is Norgestimate?

Norgestimate is a ketoxime, a steroid ester and a terminal acetylenic compound. It has a role as a contraceptive drug, a synthetic oral contraceptive and a progestin.

What is the CAS number of Norgestimate?

The CAS registry number of Norgestimate is 35189-28-7. Other or deprecated CAS numbers: 107382-52-5.

What is the molecular formula and weight of Norgestimate?

The molecular formula of Norgestimate is C23H31NO3 and its molar mass is 369.51 g/mol.

What is Norgestimate used for?

Known uses and roles of Norgestimate include hormones and steroids in pharmaceuticals, agonist, anti-hiv agent, antimicrobial agent, antiviral agent and 14 more.

Is Norgestimate hazardous?

Norgestimate carries the GHS signal word "Danger". Main hazards: harmful if swallowed, harmful in contact with skin, causes skin irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Norgestimate?

Norgestimate is usually classified under HS code 293723 (Oestrogens and progestogens). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Norgestimate?

CompoundList lists 14 suppliers of Norgestimate in Italy, United States, China, India and 2 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Norgestimate in India?

2 suppliers in India list Norgestimate on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Norgestimate?

Suppliers quote Norgestimate on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Norgestimate

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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