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Isotope-labelled compounds

Norgestrel

Also known as Norgestrel-d6, Levonorgestrel-D6, (-)-Norgestrel-d6

CAS 2376035-98-0Formula C21H28O2Molar mass 318.49 g/molEC 229-433-5
GHS signal word: Danger. Pictograms: Harmful or irritant, Serious health hazard, Hazardous to the environment 9 suppliers listed
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Norgestrel chemical structure, C21H28O2, CAS 2376035-98-0
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals from methanol
Melting point
205 to 207
Solubility
In water, 1.73 mg/L, temp not stated.
HS code
284590
Category
Isotope-labelled compounds
Illustrative photo, 25 kg white woven sacks of powder on a pallet in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Norgestrel?

Plain description, key identifiers and synonyms

Norgestrel is a synthetic progestin commonly used alone or in combination with an estrogen for contraception. Norgestrel suppresses the secretion of luteinizing and follicle-stimulating hormones (LH and FSH), thickens cervical mucus, and slows the transit of ova through the fallopian tubes. This agent also exhibits antiproliferative activity in endometrial tissue and may exhibit chemopreventive and antineoplastic activities in endometrial carcinoma. (NCI04)

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(8R,9S,10R,13S,14S,17R)-2,2,4,6,6,10-hexadeuterio-13-ethyl-17-ethynyl-17-hydroxy-7,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-3-one
CAS number
2376035-98-0Other or deprecated CAS: 6533-00-2
EC number
229-433-5
Molecular formula
C21H28O2
InChIKey
WWYNJERNGUHSAO-PWFLSJGKSA-N
InChI
InChI=1S/C21H28O2/c1-3-20-11-9-17-16-8-6-15(22)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h2,13,16-19,23H,3,5-12H2,1H3/t16-,17+,18+,19-,20-,21-/m0/s1/i5D2,6D2,13D,16D
Canonical SMILES
C#CC1(O)CCC2C3CCC4=CC(=O)CCC4C3CCC21CC
Isomeric SMILES
[2H]C1=C2[C@](CC(C1=O)([2H])[2H])([C@H]3CC[C@]4([C@H]([C@@H]3CC2([2H])[2H])CC[C@]4(C#C)O)CC)[2H]

Synonyms

  • Norgestrel-d6
  • Levonorgestrel-D6
  • (-)-Norgestrel-d6
  • Norgestrel-d6 (major)
  • (-)-Norgestrel-2,2,4,6,6,10-D6
  • (8R,9S,10R,13S,14S,17R)-2,2,4,6,6,10-hexadeuterio-13-ethyl-17-ethynyl-17-hydroxy-7,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-3-one
  • TMID-0132
  • (8R,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one-2,2,4,6,6,10-d6

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystals from methanolexp.
Melting point
205 to 207exp.
Solubility
In water, 1.73 mg/L, temp not stated.exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
318.49 g/molcalc.
Exact mass
318.2466 Dacalc.
LogP (octanol/water)
3.88calc.
Topological polar surface area
37.3 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
1calc.
Heavy atoms
23calc.
Rings
4calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.76calc.
Formal charge
0calc.
Stereocentres
6calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1C=C2CCC3C4CCCC4CCC3C2CC1

O=C1C=C2CCC3C4CCCC4CCC3C2CC1

4 rings, 18 atoms.

1,419 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H351Suspected of causing cancer.
  • H360May damage fertility or the unborn child.
  • H362May cause harm to breast-fed children.
  • H400Very toxic to aquatic life.
  • H410Very toxic to aquatic life with long lasting effects.
Precautionary statements (18)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P263Avoid contact during pregnancy and while nursing.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P318If exposed or concerned, get medical advice.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P391Collect spillage.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Norgestrel suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 9 suppliers
9 of 9 offers
  • Lupin Ltd
    India, Mumbai ManufacturerUnclaimed profile
    NorgestrelGrade Pharma (USP)
    Price on request
    View
  • Hunan KYF Pharmaceutical Co., Ltd.
    China, Jinshi ManufacturerUnclaimed profile
    NorgestrelGrade, purity and minimum order on request
    Price on request
    View
  • Sterling S.p.A.
    Italy, Corciano ManufacturerUnclaimed profile
    NorgestrelGrade, purity and minimum order on request
    Price on request
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  • Gedeon Richter Plc.
    Hungary ManufacturerUnclaimed profile
    NorgestrelGrade Pharma (USP)
    Price on request
    View
  • Bayer AG
    Germany, Leverkusen ManufacturerUnclaimed profile
    NorgestrelGrade, purity and minimum order on request
    Price on request
    View
  • Clearsynth
    United States, San DiegoUnclaimed profile
    NorgestrelGrade, purity and minimum order on request
    Price on request
    View
  • DempoChem
    Netherlands, RotterdamUnclaimed profile
    NorgestrelGrade, purity and minimum order on request
    Price on request
    View
  • EvitaChem
    China, BeijingUnclaimed profile
    NorgestrelGrade, purity and minimum order on request
    Price on request
    View
  • Veeprho
    Czech Republic, Czech RepublicUnclaimed profile
    NorgestrelGrade, purity and minimum order on request
    Price on request
    View

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

9 suppliers in 8 countries

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Norgestrel price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

How it is made

In a representative chemical synthesis, 6-methoxy-alpha-tetralone is reacted with vinylmagnesium bromide, and the resulting 1,2,3,4-tetrahydro-6-methoxy-1-vinyl-1-naphthol is condensed with 2-ethyl-1,3-cyclopentanedione to form initially a tricyclic intermediate (secosteroid) containing all of the gonane skeleton carbon atoms. Cyclization of the secosteroid via dehydration yields a 13-ethylgona-1,3,5(10)-8,14-pentaene structure which is then successively reduced and ethynylated.

Prepn: H. Smith, Belg. pat. 623,844 (1963), C.A. 61, 4427c (1964), G.A. Hughes, H. Smith, U.S. pat. 3,959,322 (1976 to Herchel Smith)

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Norgestrel is traded under.

HS 2845.90Indicative HS code

Compounds, inorganic or organic, of such isotopes, whether or not chemically defined

World exports in 2024
$2.67B
+19.0% vs 2023, imports $1.67B
2019 to 2024
Top exporters
  1. Ireland55.3%
  2. Hong Kong11.8%
  3. United States10.7%
Top importers
  1. China24.3%
  2. Ireland21.9%
  3. South Korea13.3%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Norgestrel is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Norgestrel, based on the data on this page

What is Norgestrel?

Norgestrel is a synthetic progestin commonly used alone or in combination with an estrogen for contraception. Norgestrel suppresses the secretion of luteinizing and follicle-stimulating hormones (LH and FSH), thickens cervical mucus, and slows the transit of ova through the fallopian tubes.

What is the CAS number of Norgestrel?

The CAS registry number of Norgestrel is 2376035-98-0. Other or deprecated CAS numbers: 6533-00-2.

What is the molecular formula and weight of Norgestrel?

The molecular formula of Norgestrel is C21H28O2 and its molar mass is 318.49 g/mol.

What is Norgestrel used for?

Known uses and roles of Norgestrel include isotope-labelled compounds in research and laboratory.

Is Norgestrel hazardous?

Norgestrel carries the GHS signal word "Danger". Main hazards: causes skin irritation, causes serious eye irritation, suspected of causing cancer. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Norgestrel?

Norgestrel is usually classified under HS code 284590 (Isotopes other than those of heading 2844, compounds, inorganic or organic, of such…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Norgestrel?

CompoundList lists 9 suppliers of Norgestrel in China, Czech Republic, Germany, Hungary and 4 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Norgestrel in India?

1 supplier in India list Norgestrel on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Norgestrel?

Suppliers quote Norgestrel on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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