CompoundList
Sign in
Screening compounds

Nutlin-3B

Also known as 2-Piperazinone, 4-(((4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-(4-methoxy-2-(1-methylethoxy)phenyl)-1H-imidazol-1-yl)carbonyl)-, 2-Piperazinone, 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-, (+/-)-Nutlin-3

CAS 675576-97-3Formula C30H30Cl2N4O4Molar mass 581.50 g/mol
5 suppliers listed
Get quotes Compare 5 suppliers
Nutlin-3B chemical structure, C30H30Cl2N4O4, CAS 675576-97-3
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
675576-97-3
Formula
C30H30Cl2N4O4
Molar mass
581.50 g/mol
HS code
293359
Category
Screening compounds

What is Nutlin-3B?

Plain description, key identifiers and synonyms

Nutlin-3 is a Nutlin and a piperazinone. It has a role as an anticoronaviral agent.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-[(4R,5S)-4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one
CAS number
675576-97-3 CAS number cross-checkedOther or deprecated CAS: 548472-68-0
Molecular formula
C30H30Cl2N4O4
UNII
FJA1772CVW
MDL number
MFCD11977784, MFCD11978162
InChIKey
BDUHCSBCVGXTJM-IZLXSDGUSA-N
InChI
InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)/t27-,28+/m1/s1
Canonical SMILES
COc1ccc(C2=NC(c3ccc(Cl)cc3)C(c3ccc(Cl)cc3)N2C(=O)N2CCNC(=O)C2)c(OC(C)C)c1
Isomeric SMILES
CC(C)OC1=C(C=CC(=C1)OC)C2=N[C@@H]([C@@H](N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl

Synonyms

  • 2-Piperazinone, 4-(((4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-(4-methoxy-2-(1-methylethoxy)phenyl)-1H-imidazol-1-yl)carbonyl)-
  • 2-Piperazinone, 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-
  • (+/-)-Nutlin-3
  • 4-[(4R,5S)-4,5-Bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one
  • 4-((4R,5S)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one
  • Nutlin 3b
  • (+)-Nutlin-3
  • 4-[(4R,5S)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl]piperazin-2-one
  • 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone
  • C30H30Cl2N4O4
  • Nutln 3A
  • 2-Piperazinone,4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-,rel-
  • cis-4-{[4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydroimidazol-1-yl]carbonyl}piperazin-2-one
  • 4-(cis-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one
  • 4-[(4R,5S)-4,5-Bis(4-chlorophenyl)-2-{4-methoxy-2-[(propan-2-yl)oxy]phenyl}-4,5-dihydro-1H-imidazole-1-carbonyl]piperazin-2-one
  • Nutlin (3)
  • 4-[cis-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl]piperazin-2-one
  • Nutlin-3, >=98% (HPLC), powder
  • 4-[(4R,5S)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazole-1-carbonyl]piperazin-2-one
  • (+/-)-4-[4,5-Bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one
  • 4-[(4R,5S)-4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one
  • 4-[cis-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidaZole-1-carbonyl]piperaZin-2-one (Nutlin-3)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
581.50 g/molcalc.
Exact mass
580.1644 Dacalc.
LogP (octanol/water)
5.89calc.
Topological polar surface area
83.47 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
6calc.
Heavy atoms
40calc.
Rings
5calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.3calc.
Formal charge
0calc.
Stereocentres
2calc.
Lipinski rule of five
Fails (2 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CN(C(=O)N2C(c3ccccc3)=NC(c3ccccc3)C2c2ccccc2)CCN1

O=C1CN(C(=O)N2C(c3ccccc3)=NC(c3ccccc3)C2c2ccccc2)CCN1

5 rings, 32 atoms.

12 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Nutlin-3B suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 5 suppliers
5 of 5 offers
  • Axon Medchem
    United States, RestonUnclaimed profile
    Nutlin-3BGrade, purity and minimum order on request
    Price on request
    View
  • BroadPharm
    United States, San DiegoUnclaimed profile
    Nutlin-3BGrade, purity and minimum order on request
    Price on request
    View
  • Excenen Pharmatech Co., Ltd.
    China, GuangzhouUnclaimed profile
    Nutlin-3BGrade, purity and minimum order on request
    Price on request
    View
  • Glixx Labs, Inc
    United States, HopkintonUnclaimed profile
    Nutlin-3BGrade, purity and minimum order on request
    Price on request
    View
  • Synthonix, Inc.
    United States, Wake ForestUnclaimed profile
    Nutlin-3BGrade, purity and minimum order on request
    Price on request
    View

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

5 suppliers in 2 countries

Send one request to many suppliers

Choose up to 10 suppliers or let us match your request. Compare quotes side by side, free.

Choose suppliersPost a request

Nutlin-3B price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

Get latest price

Uses and applications

What the substance is used for, by industry and function

Roles

  • anticoronaviral agent
  • antimicrobial agent
  • antiviral agent

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Nutlin-3B is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Nutlin-3B is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Nutlin-3B, based on the data on this page

What is Nutlin-3B?

Nutlin-3 is a Nutlin and a piperazinone. It has a role as an anticoronaviral agent.

What is the CAS number of Nutlin-3B?

The CAS registry number of Nutlin-3B is 675576-97-3. Other or deprecated CAS numbers: 548472-68-0.

What is the molecular formula and weight of Nutlin-3B?

The molecular formula of Nutlin-3B is C30H30Cl2N4O4 and its molar mass is 581.50 g/mol.

What is Nutlin-3B used for?

Known uses and roles of Nutlin-3B include building blocks in research and laboratory, screening compounds in research and laboratory, anticoronaviral agent, antimicrobial agent and antiviral agent.

Is Nutlin-3B hazardous?

No GHS hazard classification for Nutlin-3B is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Nutlin-3B?

Nutlin-3B is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Nutlin-3B?

CompoundList lists 5 suppliers of Nutlin-3B in United States and China. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Nutlin-3B?

Suppliers quote Nutlin-3B on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Nutlin-3B

Get quotes for Nutlin-3B

Post one free request with your grade, quantity and destination. Matching suppliers send quotes you can compare side by side.
Post a request Sell Nutlin-3B
Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
Embed this structure on your websiteShow code

Paste this code into your page to show the 2D structure of Nutlin-3B with a 3D view, its CAS number where known and a link back to this page. Free to use with the link kept.

<iframe src="https://www.compoundlist.com/embed/structure/nutlin-3b-675576-97-3" title="Nutlin-3B structure on CompoundList" width="360" height="420" style="border:1px solid #E7E2DA;border-radius:12px;max-width:100%" loading="lazy" referrerpolicy="strict-origin-when-cross-origin"></iframe>
Preview the embed

Explore more in Screening compounds or HS code 293359

5 suppliers
Free quotes, contact stays private
Get quotes