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Murcko scaffold

Ring system with 5 rings and 32 atoms

13 chemicals on CompoundList share this ring system.

Rings
5
Scaffold atoms
32
Chemicals
13
With full pages
3
Scaffold SMILES

O=C1CN(C(=O)N2C(c3ccccc3)=NC(c3ccccc3)C2c2ccccc2)CCN1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1CN(C(=O)N2C(c3ccccc3)=NC(c3ccccc3)C2c2ccccc2)CCN1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 13 of 13 chemicals

4-(4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one chemical structure, C30H30Cl2N4O4, CAS 890090-75-2
4-(4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one
CAS 890090-75-2C30H30Cl2N4O4
Nutlin 3 chemical structure, C30H30Cl2N4O4, CAS 548472-68-0
Nutlin 3
CAS 548472-68-0C30H30Cl2N4O4
Nutlin-3B chemical structure, C30H30Cl2N4O4, CAS 675576-97-3
Nutlin-3B
CAS 675576-97-3C30H30Cl2N4O4
4-[4,5-Bis(3,4-dichlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one chemical structure, C30H28Cl4N4O4
4-[4,5-Bis(3,4-dichlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one
C30H28Cl4N4O4
4-[(4S,5R)-2-(4-Methoxy-2-propan-2-yloxyphenyl)-4,5-bis[4-(trifluoromethyl)phenyl]-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one chemical structure, C32H30F6N4O4
4-[(4S,5R)-2-(4-Methoxy-2-propan-2-yloxyphenyl)-4,5-bis[4-(trifluoromethyl)phenyl]-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one
C32H30F6N4O4
4-[(4S,5R)-4,5-Bis(3,4-dichlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one chemical structure, C30H28Cl4N4O4
4-[(4S,5R)-4,5-Bis(3,4-dichlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one
C30H28Cl4N4O4
Caylin-1 chemical structure, C30H28Cl4N4O4, CAS 1207480-88-3
Caylin-1
CAS 1207480-88-3C30H28Cl4N4O4
4-[(4R,5S)-2-(4-Methoxy-2-propan-2-yloxyphenyl)-4,5-bis[4-(trifluoromethyl)phenyl]-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one chemical structure, C32H30F6N4O4, CAS 1392830-09-9
4-[(4R,5S)-2-(4-Methoxy-2-propan-2-yloxyphenyl)-4,5-bis[4-(trifluoromethyl)phenyl]-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one
CAS 1392830-09-9C32H30F6N4O4
Nutlin carboxylic acid chemical structure, C32H32Cl2N4O6, CAS 2249750-27-2
Nutlin carboxylic acid
CAS 2249750-27-2C32H32Cl2N4O6
Nutlin-C1-amido-PEG4-C2-N3 chemical structure, C42H52Cl2N8O9, CAS 2369022-70-6
Nutlin-C1-amido-PEG4-C2-N3
CAS 2369022-70-6C42H52Cl2N8O9
(4R,5S)-Nutlin carboxylic acid chemical structure, C32H32Cl2N4O6, CAS 2306390-08-7
(4R,5S)-Nutlin carboxylic acid
CAS 2306390-08-7C32H32Cl2N4O6
Orb3210977 chemical structure, C36H40Cl2N8O6, CAS 2977227-58-8
Orb3210977
CAS 2977227-58-8C36H40Cl2N8O6
Orb3211163 chemical structure, C38H44Cl2N8O7, CAS 3035510-04-1
Orb3211163
CAS 3035510-04-1C38H44Cl2N8O7