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Impurities and reference standards

Oxymorphone hydrochloride

Also known as Oxymorphone HCl, Opana ER, Oxymorphone hydrochloride (USP)

CAS 357-07-3Formula C17H20ClNO4Molar mass 337.80 g/molEC 206-610-5
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant, Serious health hazard Prohibited, not for trade Drug substance
Why it is not for trade
Oxymorphone hydrochloride chemical structure, C17H20ClNO4, CAS 357-07-3
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
357-07-3
Formula
C17H20ClNO4
Molar mass
337.80 g/mol
EC number
206-610-5
HS code
293499
Category
Impurities and reference standards

What is Oxymorphone hydrochloride?

Plain description, key identifiers and synonyms

Oxymorphone hydrochloride is a member of phenanthrenes.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-methyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one, hydrochloride
CAS number
357-07-3 CAS number cross-checked
EC number
206-610-5
Molecular formula
C17H20ClNO4
UNII
5Y2EI94NBC
InChIKey
BCGJBQBWUGVESK-KCTCKCTRSA-N
InChI
InChI=1S/C17H19NO4.ClH/c1-18-7-6-16-13-9-2-3-10(19)14(13)22-15(16)11(20)4-5-17(16,21)12(18)8-9;/h2-3,12,15,19,21H,4-8H2,1H3;1H/t12-,15+,16+,17-;/m1./s1
Canonical SMILES
CN1CCC23c4c5ccc(O)c4OC2C(=O)CCC3(O)C1C5.Cl
Isomeric SMILES
CN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)O.Cl

Synonyms

  • Oxymorphone HCl
  • Opana ER
  • Oxymorphone hydrochloride (USP)
  • 4,5-alpha-Epoxy-3,14-dihydroxy-17-methylmorphinan-6-one hydrochloride
  • Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-methyl-, hydrochloride, (5alpha)-
  • Numorphan
  • Opana
  • 4,5alpha-Epoxy-3,14-dihydroxy-17-methylmorphinan-6-one hydrochloride
  • Oxymorphone hcl narcotic analgesic
  • (4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-methyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one, hydrochloride
  • Oxymorphinone hydrochloride
  • Oxycodone Hydrochloride EP Impurity A
  • Numorphan (TN)
  • Opana (TN)
  • 76-41-5 free base
  • (5alpha)-4,5-Epoxy-3,14-dihydroxy-17-methylmorphinan-6-one hydrochloride
  • Morphinan-6-one, 3,14-dihydroxy-4,5-alpha-epoxy-17-methyl-, hydrochloride
  • 3,14-Dihydroxy-17-methyl-5alpha-4,5-epoxymorphinan-6-one--hydrogen chloride (1/1)
  • Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-methyl-, hydrochloride, (5.alpha.)-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
337.80 g/molcalc.
Exact mass
337.1081 Dacalc.
LogP (octanol/water)
1.17calc.
Topological polar surface area
70 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
0calc.
Heavy atoms
23calc.
Rings
5calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.59calc.
Formal charge
0calc.
Stereocentres
4calc.
Components
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CCC2C3Cc4cccc5c4C2(CCN3)C1O5

O=C1CCC2C3Cc4cccc5c4C2(CCN3)C1O5

5 rings, 19 atoms.

148 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H301Toxic if swallowed.
  • H302Harmful if swallowed.
  • H310Fatal in contact with skin.
  • H311Toxic in contact with skin.
  • H315Causes skin irritation.
  • H317May cause an allergic skin reaction.
  • H319Causes serious eye irritation.
  • H330Fatal if inhaled.
  • H334May cause allergy or asthma symptoms or breathing difficulties if inhaled.
  • H361Suspected of damaging fertility or the unborn child.
Precautionary statements (32)
  • P203Obtain, read and follow all safety instructions before use.
  • P233Keep container tightly closed.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P262Do not get in eyes, on skin, or on clothing.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P284In case of inadequate ventilation wear respiratory protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P316Get emergency medical help immediately.
  • P318If exposed or concerned, get medical advice.
  • P320Specific treatment is urgent (see supplemental first aid instructions on the label).
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P342 + P316If experiencing respiratory symptoms: Get emergency medical help immediately.
  • P361 + P364Take off immediately all contaminated clothing. And wash it before reuse.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403Store in a well-ventilated place.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Oxymorphone hydrochloride suppliers

Trading restrictions apply to this substance

Controlled or monitored substance

Oxymorphone hydrochloride is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Our policy on controlled substances

Oxymorphone hydrochloride price

Indicative price range per kg from live supplier offers

Prices are not shown for prohibited substances.

Uses and applications

What the substance is used for, by industry and function

Pharmacology

Oxymorphone Hydrochloride is the hydrochloride salt form of oxymorphone, a semisynthetic opioid with a potent analgesic property. Oxymorphone hydrochloride binds to and activates opiate receptors, specifically mu-receptors, in the central nervous system (CNS). This results in sedation, analgesia, decreased gastrointestinal motility, and respiratory depression.

Regulatory status

Inventories, regulations and trade controls that list this substance

Controlled or monitored substance

Oxymorphone hydrochloride is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Our policy on controlled substances

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Oxymorphone hydrochloride is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Oxymorphone hydrochloride is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Oxymorphone hydrochloride, based on the data on this page

What is Oxymorphone hydrochloride?

Oxymorphone hydrochloride is a member of phenanthrenes.

Is Oxymorphone hydrochloride hazardous?

Oxymorphone hydrochloride carries the GHS signal word "Danger". Main hazards: toxic if swallowed, harmful if swallowed, fatal in contact with skin. This summary is not an SDS, always read the supplier safety data sheet.

Can I buy Oxymorphone hydrochloride on CompoundList?

No. Oxymorphone hydrochloride is on our prohibited list, so listings, quotes and messages for it are disabled. This page is kept for information only.

Guides for buyers

Practical guides that help when you source, ship or handle Oxymorphone hydrochloride

Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page

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