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Analgesics and anti-inflammatories

Oxymorphone

Also known as Oximorphonum, 14-Hydroxydihydromorphinone, Dihydrohydroxymorphinone

CAS 76-41-5Formula C17H19NO4Molar mass 301.34 g/molEC 200-959-7
GHS signal word: Danger. Pictograms: Acute toxicity (severe) Prohibited, not for trade Drug substance
Why it is not for trade
Oxymorphone chemical structure, C17H19NO4, CAS 76-41-5
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals from boiling ethanol, ethyl acetate, or benzene
Melting point
248 to 249
Solubility
Soluble in boiling acetone and chloroform, readily soluble in aqueous alkalies, moderate…
HS code
293911
Category
Analgesics and anti-inflammatories

What is Oxymorphone?

Plain description, key identifiers and synonyms

Oxymorphone is a morphinane alkaloid.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-methyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
CAS number
76-41-5 CAS number cross-checked
EC number
200-959-7
Molecular formula
C17H19NO4
UNII
9VXA968E0C
InChIKey
UQCNKQCJZOAFTQ-ISWURRPUSA-N
InChI
InChI=1S/C17H19NO4/c1-18-7-6-16-13-9-2-3-10(19)14(13)22-15(16)11(20)4-5-17(16,21)12(18)8-9/h2-3,12,15,19,21H,4-8H2,1H3/t12-,15+,16+,17-/m1/s1
Canonical SMILES
CN1CCC23c4c5ccc(O)c4OC2C(=O)CCC3(O)C1C5
Isomeric SMILES
CN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)O

Synonyms

  • Oximorphonum
  • 14-Hydroxydihydromorphinone
  • Dihydrohydroxymorphinone
  • Dihydroxymorphinone
  • Oximorfona
  • (-)-Oxymorphone
  • 7,8-Dihydro-14-hydroxymorphinone
  • Oxymorphonum
  • Oxymorphone cii
  • Dihydro-14-hydroxymorphinone
  • (14S)-14-Hydroxydihydromorphinone
  • Morphinone, dihydro-14-hydroxy-
  • NIH 10323
  • Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-methyl-, (5alpha)-
  • Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-methyl-
  • Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-methyl-, (5-alpha)-
  • (4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-methyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
  • oximorfone
  • (1S,5R,13R,17S)-10,17-dihydroxy-4-methyl-12-oxa-4-azapentacyclo(9.6.1.0^(1,13).0^(5,17).0^(7,18))octadeca-7(18),8,10-trien-14-one
  • (1S,5R,13R,17S)-10,17-dihydroxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7(18),8,10-trien-14-one
  • (4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-methyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro(3,2-e)isoquinolin-7-one
  • (4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-methyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro(3,2-e)isoquinoline-7-one
  • (4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-methyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one
  • 4,5alpha-Epoxy-3,14-dihydroxy-17-methylmorphinan-6-one
  • (1S,5R,13R,17S)-10,17-dihydroxy-4-methyl-12-oxa-4-azapentacyclo(9.6.1.01,13.05,17.07,18)octadeca-7(18),8,10-trien-14-one
Show all 35 synonyms
  • Numorphan
  • Oxymorphine
  • Opana
  • Numorphone
  • Oxymorphone (INN)
  • 3,14-Dihydroxy-4,5-alpha-epoxy-17-methylmorphinan-6-one
  • Oxycodone Hydrochloride EP Impurity A
  • Ossimorfone
  • Morphinan-6-one, 3,14-dihydroxy-4,5-alpha-epoxy-17-methyl-
  • Oxymorphone (1.0 mg/mL in Methanol)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystals from boiling ethanol, ethyl acetate, or benzeneexp.
Melting point
248 to 249exp.
Solubility
Soluble in boiling acetone and chloroform, readily soluble in aqueous alkalies, moderately soluble in boiling ethanol, sparingly soluble in benzeneexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
301.34 g/molcalc.
Exact mass
301.1314 Dacalc.
LogP (octanol/water)
0.75calc.
Topological polar surface area
70 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
0calc.
Heavy atoms
22calc.
Rings
5calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.59calc.
Formal charge
0calc.
Stereocentres
4calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CCC2C3Cc4cccc5c4C2(CCN3)C1O5

O=C1CCC2C3Cc4cccc5c4C2(CCN3)C1O5

5 rings, 19 atoms.

148 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)

Hazard statements

  • H300Fatal if swallowed.
  • H310Fatal in contact with skin.
  • H330Fatal if inhaled.
Precautionary statements (18)
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P262Do not get in eyes, on skin, or on clothing.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P284In case of inadequate ventilation wear respiratory protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P316Get emergency medical help immediately.
  • P320Specific treatment is urgent (see supplemental first aid instructions on the label).
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P361 + P364Take off immediately all contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Oxymorphone suppliers

Trading restrictions apply to this substance

Narcotic drug

Oxymorphone is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: UN Single Convention on Narcotic Drugs 1961, HS 2022 subheading 2939.11 (opium alkaloids and their derivatives)

Our policy on controlled substances

Oxymorphone price

Indicative price range per kg from live supplier offers

Prices are not shown for prohibited substances.

Uses and applications

What the substance is used for, by industry and function

Oxymorphone is a Schedule II controlled substance.

Schedule II Controlled Substance: (A) The drug or other substance has a high potential for abuse, (B) The drug or other substance has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions, and (C) Abuse of the drug or other substances may lead to severe psychological or physical dependence.

Veterinary medication:.

Use classes: Pharmaceuticals.

Pharmacological actions

  • Adjuvants, Anesthesia
  • Analgesics, Opioid
  • Narcotics

Functional uses

  • Pharmaceutical

Pharmacology

Oxymorphone is an Opioid Agonist. The mechanism of action of oxymorphone is as a Full Opioid Agonist.

How it is made

Oxycodone is hydrolyzed with boiling concentrated hydrobromic acid.

Thebaine is dissolved in aqueous formic acid and treated with 30% hydrogen peroxide, after which neutralization with aqueous ammonia yields 14-hydroxycodeinone. This then is dissolved in acetic acid and hydrogenated with the aid of palladium-charcoal catalyst to form 14-hydroxy-7,8-dihydrocodeinone (oxycodone). In the form of its hydrochloride, this compound is demethylated by means of heating with pyridine hydrochloride to yield crude oxymorphone hydrochloride, which is then purified. (Oxymorphone hydrochloride)

Regulatory status

Inventories, regulations and trade controls that list this substance

Narcotic drug

Oxymorphone is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: UN Single Convention on Narcotic Drugs 1961, HS 2022 subheading 2939.11 (opium alkaloids and their derivatives)

Our policy on controlled substances

Controls

  • US DEA controlled substance or listed chemical
  • Controlled narcotic drug

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Oxymorphone is traded under.

HS 2939.11Exact HS code

Concentrates of poppy straw, buprenorphine (INN), codeine, dihydrocodeine (INN)…

World exports in 2024
$246M
−3.8% vs 2023, imports $339M
2019 to 2024
Top exporters
  1. United Kingdom33.3%
  2. Spain21.3%
  3. Czech Republic8.6%
Top importers
  1. United States30.8%
  2. United Kingdom13.2%
  3. Germany6.3%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Oxymorphone is indicative (it was matched by name in the HS nomenclature). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Oxymorphone, based on the data on this page

What is Oxymorphone?

Oxymorphone is a morphinane alkaloid.

What is the CAS number of Oxymorphone?

The CAS registry number of Oxymorphone is 76-41-5.

What is the molecular formula and weight of Oxymorphone?

The molecular formula of Oxymorphone is C17H19NO4 and its molar mass is 301.34 g/mol.

What is Oxymorphone used for?

Oxymorphone is a Schedule II controlled substance. Schedule II Controlled Substance: (A) The drug or other substance has a high potential for abuse, (B) The drug or other substance has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions, and (…

Is Oxymorphone hazardous?

Oxymorphone carries the GHS signal word "Danger". Main hazards: fatal if swallowed, fatal in contact with skin, fatal if inhaled. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Oxymorphone?

Oxymorphone is usually classified under HS code 293911 (Concentrates of poppy straw, buprenorphine (INN), codeine, dihydrocodeine (INN)…). This is indicative, confirm it with your customs broker before shipping.

Can I buy Oxymorphone on CompoundList?

No. Oxymorphone is on our prohibited list, so listings, quotes and messages for it are disabled. This page is kept for information only.

Guides for buyers

Practical guides that help when you source, ship or handle Oxymorphone

Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page

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