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Analgesics and anti-inflammatories

Oxycodone

Also known as Dihydrone, Dihydrohydroxycodeinone, Dihydroxycodeinone

CAS 76-42-6Formula C18H21NO4Molar mass 315.37 g/molEC 200-960-2
GHS signal word: Warning. Pictograms: Harmful or irritant, Serious health hazard Prohibited, not for trade Drug substance
Why it is not for trade
Oxycodone chemical structure, C18H21NO4, CAS 76-42-6
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Rods from ethanol
Melting point
219 °C
Solubility
Insoluble in water
HS code
293911
Category
Analgesics and anti-inflammatories

What is Oxycodone?

Plain description, key identifiers and synonyms

Oxycodone is a semisynthetic opioid of formula C18H21NO4 that is derived from thebaine. It is a moderately potent opioid analgesic, generally used for relief of moderate to severe pain. It has a role as an opioid analgesic, an antitussive and a mu-opioid receptor agonist. It is an organic heteropentacyclic compound and a semisynthetic derivative. It is functionally related to a thebaine. It is a conjugate base of an oxycodone(1+). It derives from a hydride of a morphinan.

Oxycodone is an analgesic alkaloid (opioid).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(4R,4aS,7aR,12bS)-4a-hydroxy-9-methoxy-3-methyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
CAS number
76-42-6 CAS number cross-checked
EC number
200-960-2
Molecular formula
C18H21NO4
UNII
CD35PMG570
InChIKey
BRUQQQPBMZOVGD-XFKAJCMBSA-N
InChI
InChI=1S/C18H21NO4/c1-19-8-7-17-14-10-3-4-12(22-2)15(14)23-16(17)11(20)5-6-18(17,21)13(19)9-10/h3-4,13,16,21H,5-9H2,1-2H3/t13-,16+,17+,18-/m1/s1
Canonical SMILES
COc1ccc2c3c1OC1C(=O)CCC4(O)C(C2)N(C)CCC314
Isomeric SMILES
CN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)OC)O4)O

Synonyms

  • Dihydrone
  • Dihydrohydroxycodeinone
  • Dihydroxycodeinone
  • Diphydrone
  • Oxicodona
  • Endone
  • Oxanest
  • (-)-14-Hydroxydihydrocodeinone
  • Dihydro-14-hydroxycodeinone
  • Oxycodonum
  • Xtampza
  • Remoxy
  • 14-Hydroxydihydrocodeinone
  • OxyIR
  • Endine (Australia)
  • Xtampza ER
  • Eubine [France]
  • Supendol [Canada]
  • (-)-Oxycodone
  • Codeinone, dihydrohydroxy-
  • Pavinal
  • Oxycodone cii
  • 4,5alpha-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one
  • Codeinone, dihydro-14-hydroxy-
  • oxymorphone 3-methyl ether
Show all 39 synonyms
  • Pancodone retard (United Kingdom)
  • 4,5-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one
  • Pti 821
  • Codeinone, 7,8-dihydro-14-hydroxy-
  • Eubine (France)
  • Morphinan-6-one, 4,5alpha-epoxy-14-hydroxy-3-methoxy-17-methyl-
  • Morphinan-6-one, 4,5-epoxy-14-hydroxy-3-methoxy-17-methyl-, (5alpha)-
  • Supendol (Canada)
  • Oxycodeinon
  • Oxycone
  • (4R,4aS,7aR,12bS)-4a-hydroxy-9-methoxy-3-methyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
  • oxicodone
  • Proladone
  • Oxycodone SR

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Rods from ethanolexp.
Melting point
219 °Cexp.
Solubility
Insoluble in waterexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
315.37 g/molcalc.
Exact mass
315.1471 Dacalc.
LogP (octanol/water)
1.05calc.
Topological polar surface area
59 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
1calc.
Heavy atoms
23calc.
Rings
5calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.61calc.
Formal charge
0calc.
Stereocentres
4calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CCC2C3Cc4cccc5c4C2(CCN3)C1O5

O=C1CCC2C3Cc4cccc5c4C2(CCN3)C1O5

5 rings, 19 atoms.

148 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302Harmful if swallowed.
  • H336May cause drowsiness or dizziness.
  • H361dSuspected of damaging the unborn child.
  • H361fdSuspected of damaging fertility. Suspected of damaging the unborn child.
  • H362May cause harm to breast-fed children.
Precautionary statements (16)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P263Avoid contact during pregnancy and while nursing.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P330Rinse mouth.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Oxycodone suppliers

Trading restrictions apply to this substance

Narcotic drug

Oxycodone is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: UN Single Convention on Narcotic Drugs 1961, HS 2022 subheading 2939.11 (opium alkaloids and their derivatives)

Our policy on controlled substances

Oxycodone price

Indicative price range per kg from live supplier offers

Prices are not shown for prohibited substances.

Uses and applications

What the substance is used for, by industry and function

Oxycodone (DEA Code Number: 9143) is a Schedule II controlled substance.

Schedule II Controlled Substance: (A) The drug or other substance has a high potential for abuse, (B) The drug or other substance has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions, and (C) Abuse of the drug or other substances may lead to severe psychological or physical dependence.

Narcotics, Analgesics, Opioid.

Use classes: Pharmaceuticals.

Pharmacological actions

  • Analgesics, Opioid
  • Narcotics

Roles

  • agonist
  • analgesic
  • antitussive
  • mu-opioid agent
  • mu-opioid receptor agonist
  • neurotransmitter agent
  • opioid agent
  • opioid analgesic
  • opioid receptor agonist
  • pharmaceutical

Functional uses

  • Pharmaceutical

Pharmacology

Oxycodone is an Opioid Agonist. The mechanism of action of oxycodone is as a Full Opioid Agonist.

How it is made

Thebaine is oxidized with hydrogene peroxide to 14-hydroxycodeinone, which is hydrogenated directly or via its oxime, or its bromination products to oxycodone. The reduction of 14-hydroxycodeinone can also be performed with sodium hydrosulfite. Alternatively, 14-hydroxycodeinone is prepared by oxidation of codeine.

Regulatory status

Inventories, regulations and trade controls that list this substance

Narcotic drug

Oxycodone is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: UN Single Convention on Narcotic Drugs 1961, HS 2022 subheading 2939.11 (opium alkaloids and their derivatives)

Our policy on controlled substances

Controls

  • US DEA controlled substance or listed chemical
  • Controlled narcotic drug

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Oxycodone is traded under.

HS 2939.11Exact HS code

Concentrates of poppy straw, buprenorphine (INN), codeine, dihydrocodeine (INN)…

World exports in 2024
$246M
−3.8% vs 2023, imports $339M
2019 to 2024
Top exporters
  1. United Kingdom33.3%
  2. Spain21.3%
  3. Czech Republic8.6%
Top importers
  1. United States30.8%
  2. United Kingdom13.2%
  3. Germany6.3%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Oxycodone is indicative (it was matched by name in the HS nomenclature). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Oxycodone, based on the data on this page

What is Oxycodone?

Oxycodone is a semisynthetic opioid of formula C18H21NO4 that is derived from thebaine. It is a moderately potent opioid analgesic, generally used for relief of moderate to severe pain. It has a role as an opioid analgesic, an antitussive and a mu-opioid receptor agonist.

What is the CAS number of Oxycodone?

The CAS registry number of Oxycodone is 76-42-6.

What is the molecular formula and weight of Oxycodone?

The molecular formula of Oxycodone is C18H21NO4 and its molar mass is 315.37 g/mol.

What is Oxycodone used for?

Oxycodone (DEA Code Number: 9143) is a Schedule II controlled substance. Schedule II Controlled Substance: (A) The drug or other substance has a high potential for abuse, (B) The drug or other substance has a currently accepted medical use in treatment in the United States or a currently accepted medical use with seve…

Is Oxycodone hazardous?

Oxycodone carries the GHS signal word "Warning". Main hazards: harmful if swallowed, may cause drowsiness or dizziness, suspected of damaging the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Oxycodone?

Oxycodone is usually classified under HS code 293911 (Concentrates of poppy straw, buprenorphine (INN), codeine, dihydrocodeine (INN)…). This is indicative, confirm it with your customs broker before shipping.

Can I buy Oxycodone on CompoundList?

No. Oxycodone is on our prohibited list, so listings, quotes and messages for it are disabled. This page is kept for information only.

Guides for buyers

Practical guides that help when you source, ship or handle Oxycodone

Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page

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