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Sulfur and phosphorus compounds

Palifosfamide

Also known as Isophosphamide mustard, Ifosfamide mustard, Isophosphoramide mustard

CAS 31645-39-3Formula C4H11Cl2N2O2PMolar mass 221.02 g/mol
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Palifosfamide chemical structure, C4H11Cl2N2O2P, CAS 31645-39-3
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
31645-39-3
Formula
C4H11Cl2N2O2P
Molar mass
221.02 g/mol
HS code
294200
Category
Sulfur and phosphorus compounds

What is Palifosfamide?

Plain description, key identifiers and synonyms

Isophosphamide mustard is a phosphorodiamide.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
bis(2-chloroethylamino)phosphinic acid
CAS number
31645-39-3 CAS number cross-checked
Molecular formula
C4H11Cl2N2O2P
UNII
6A4U6NN813
InChIKey
BKCJZNIZRWYHBN-UHFFFAOYSA-N
InChI
InChI=1S/C4H11Cl2N2O2P/c5-1-3-7-11(9,10)8-4-2-6/h1-4H2,(H3,7,8,9,10)
SMILES (canonical and isomeric)
C(CCl)NP(=O)(NCCCl)O

Synonyms

  • Isophosphamide mustard
  • Ifosfamide mustard
  • Isophosphoramide mustard
  • Phosphorodiamidic acid, N,N'-bis(2-chloroethyl)-
  • Ifosforamide mustard
  • Palifosfamida
  • N,N'-Bis(2-chloroethyl)phosphorodiamidic acid
  • N,N'-Di-(2-chloroethyl)phosphorodiamidic acid
  • N,N'-Bis-(2-chloroethyl)phosphoric acid
  • N1,N2-Bis(2-chloroethyl)phosphoric acid diamide
  • bis[(2-chloroethyl)amino]phosphinic acid
  • Palifosfamide (mart.)
  • bis((2-chloroethyl)amino)phosphinic acid
  • palifosfamidum
  • IPM-Lysine
  • iphosphoramide mustard
  • Isophosphoramide Mustard-Lysine
  • bis(2-chloroethylamino)phosphinic acid
  • IPAM
  • Isophosphoramide mustard, IPM, ZIO-201
  • Phosphorodiamidic acid,N'-bis(2-chloroethyl)-
  • Palifosfamide?
  • ZIO 201
  • Palifosfamide (USAN/INN)
  • C4H11Cl2N2O2P
Show all 27 synonyms
  • N,N'-Bis(2-chloroethyl)phosphorodiamidic acid #
  • N,N inverted exclamation marka-Bis(2-chloroethyl)phosphorodiamidic acid

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
221.02 g/molcalc.
Exact mass
219.9935 Dacalc.
LogP (octanol/water)
0.74calc.
Topological polar surface area
61.36 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
1calc.
Rotatable bonds
6calc.
Heavy atoms
11calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Palifosfamide suppliers

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Where suppliers are based

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Palifosfamide price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Antineoplastic Agents, Alkylating

Roles

  • antineoplastic agent
  • pharmaceutical

Pharmacology

Palifosfamide is a synthetic mustard compound with potential antineoplastic activity. An active metabolite of ifosfamide covalently linked to the amino acid lysine for stability, palifosfamide irreversibly alkylates and cross-links DNA through GC base pairs, resulting in irreparable 7-atom inter-strand cross-links, inhibition of DNA replication and cell death follow. Unlike ifosfamide, this agent is not metabolized to acrolein or chloroacetaldehyde, metabolites associated with bladder and CNS toxicities. In addition, because palifosfamide does not require activation by aldehyde dehydrogenase, it may overcome the tumor resistance seen with ifosfamide.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Palifosfamide is traded under.

HS 2942.00Indicative HS code

Organic compounds not elsewhere classified in chapter 29

World exports in 2024
$589M
−43.5% vs 2023, imports $614M
2019 to 2024
Top exporters
  1. India * partner reported20.7%
  2. United States18.6%
  3. Italy10.4%
Top importers
  1. United States15.1%
  2. Italy6.7%
  3. Japan5.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Palifosfamide is indicative (it is known at chapter level only). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Palifosfamide, based on the data on this page

What is Palifosfamide?

Isophosphamide mustard is a phosphorodiamide.

What is the CAS number of Palifosfamide?

The CAS registry number of Palifosfamide is 31645-39-3.

What is the molecular formula and weight of Palifosfamide?

The molecular formula of Palifosfamide is C4H11Cl2N2O2P and its molar mass is 221.02 g/mol.

What is Palifosfamide used for?

Known uses and roles of Palifosfamide include building blocks in research and laboratory, antineoplastic agent, pharmaceutical and antineoplastic agents, alkylating.

Is Palifosfamide hazardous?

No GHS hazard classification for Palifosfamide is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Palifosfamide?

Palifosfamide is usually classified under HS code 294200 (XIII. OTHER ORGANIC COMPOUNDS, other organic compounds). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Palifosfamide?

CompoundList lists 1 supplier of Palifosfamide in United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Palifosfamide?

Suppliers quote Palifosfamide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Palifosfamide

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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