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Sulfur and phosphorus compounds

Phosphoramide mustard

Also known as Phosphamide mustard, Friedman acid, N,N-Bis(2-chloroethyl)phosphorodiamidic acid

CAS 10159-53-2Formula C4H11Cl2N2O2PMolar mass 221.02 g/mol
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Phosphoramide mustard chemical structure, C4H11Cl2N2O2P, CAS 10159-53-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
10159-53-2
Formula
C4H11Cl2N2O2P
Molar mass
221.02 g/mol
HS code
294200
Category
Sulfur and phosphorus compounds

What is Phosphoramide mustard?

Plain description, key identifiers and synonyms

Phosphoramide mustard is a phosphorodiamide and a nitrogen mustard.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
amino-[bis(2-chloroethyl)amino]phosphinic acid
CAS number
10159-53-2 CAS number cross-checked
Molecular formula
C4H11Cl2N2O2P
UNII
4K9ULD24RM
InChIKey
RJXQSIKBGKVNRT-UHFFFAOYSA-N
InChI
InChI=1S/C4H11Cl2N2O2P/c5-1-3-8(4-2-6)11(7,9)10/h1-4H2,(H3,7,9,10)
SMILES (canonical and isomeric)
C(CCl)N(CCCl)P(=O)(N)O

Synonyms

  • Phosphamide mustard
  • Friedman acid
  • N,N-Bis(2-chloroethyl)phosphorodiamidic acid
  • Phosphorodiamidic mustard
  • Phosphorodiamidic acid, N,N-bis(2-chloroethyl)-
  • amino-[bis(2-chloroethyl)amino]phosphinic acid
  • Protamine phosphoramide mustard
  • NLPD
  • ASTA 5317
  • N-Lost-phosphorsaeurediamid
  • Phosphorodiamidic acid,N-bis(2-chloroethy)-, mixt. with protamine
  • N,N-di-(2-chloroethyl)-phosphorodiamidic acid
  • Protamine,N-bis(2-chloroethyl)phosphorodiamidic acid

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
221.02 g/molcalc.
Exact mass
219.9935 Dacalc.
LogP (octanol/water)
0.83calc.
Topological polar surface area
66.56 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
1calc.
Rotatable bonds
5calc.
Heavy atoms
11calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Phosphoramide mustard suppliers

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Phosphoramide mustard price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacology

Phosphoramide Mustard is one of a number of chemically-related alkylating agents with antineoplastic properties. The prototype of this group of agents is cyclophosphamide. Most phosphoramide mustards are administered as prodrugs that undergo reductive activation in hypoxic environments to yield cytotoxic metabolites. These agents alkylate and crosslink DNA, resulting in inhibition of DNA replication. Phosphoramide mustards are also immunosuppressants, mutagens and teratogens. (NCI04)

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Phosphoramide mustard is traded under.

HS 2942.00Indicative HS code

Organic compounds not elsewhere classified in chapter 29

World exports in 2024
$589M
−43.5% vs 2023, imports $614M
2019 to 2024
Top exporters
  1. India * partner reported20.7%
  2. United States18.6%
  3. Italy10.4%
Top importers
  1. United States15.1%
  2. Italy6.7%
  3. Japan5.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Phosphoramide mustard is indicative (it is known at chapter level only). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Phosphoramide mustard, based on the data on this page

What is Phosphoramide mustard?

Phosphoramide mustard is a phosphorodiamide and a nitrogen mustard.

What is the CAS number of Phosphoramide mustard?

The CAS registry number of Phosphoramide mustard is 10159-53-2.

What is the molecular formula and weight of Phosphoramide mustard?

The molecular formula of Phosphoramide mustard is C4H11Cl2N2O2P and its molar mass is 221.02 g/mol.

What is Phosphoramide mustard used for?

Known uses and roles of Phosphoramide mustard include building blocks in research and laboratory.

Is Phosphoramide mustard hazardous?

No GHS hazard classification for Phosphoramide mustard is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Phosphoramide mustard?

Phosphoramide mustard is usually classified under HS code 294200 (XIII. OTHER ORGANIC COMPOUNDS, other organic compounds). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Phosphoramide mustard?

Post a free request on CompoundList and suppliers of Phosphoramide mustard will send you quotes. Your contact details stay private until you accept a quote.

What is the price of Phosphoramide mustard?

Suppliers quote Phosphoramide mustard on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Phosphoramide mustard

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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