Piperidine
Also known as Hexahydropyridine, Cyclopentimine, Azacyclohexane
Key facts
What buyers check first
- Appearance
- Clear, colorless liquid
- Melting point
- -7 °C
- Boiling point
- 106 °C
- Density
- Relative density (water = 1): 0.86
- Flash point
- 16 °C
- HS code
- 293332
- Category
- Polymers and thermoplastics
- UN number
- UN 2401
What is Piperidine?
Plain description, key identifiers and synonyms
Piperidine is an azacycloalkane that is cyclohexane in which one of the carbons is replaced by a nitrogen. It is a metabolite of cadaverine, a polyamine found in the human intestine. It has a role as a base, a reagent, a catalyst, a non-polar solvent, a protic solvent, a plant metabolite and a human metabolite. It is a member of piperidines, a secondary amine, a saturated organic heteromonocyclic parent and an azacycloalkane. It is a conjugate base of a piperidinium.
Identifiers
Registry numbers, names and line notations, tap to copy
- IUPAC name
- piperidine
- CAS number
- 110-89-4 CAS number cross-checkedOther or deprecated CAS: 52167-54-1, 89014-30-2
- EC number
- 203-813-0
- Molecular formula
- C5H11N
- UNII
- 67I85E138Y
- MDL number
- MFCD00005979
- InChIKey
- NQRYJNQNLNOLGT-UHFFFAOYSA-N
- InChI
- InChI=1S/C5H11N/c1-2-4-6-5-3-1/h6H,1-5H2
- SMILES (canonical and isomeric)
- C1CCNCC1
Synonyms
- Hexahydropyridine
- Cyclopentimine
- Azacyclohexane
- Hexazane
- Cypentil
- Pentamethyleneimine
- Piperidin
- Pentamethylenimine
- Perhydropyridine
- Pyridine, hexahydro-
- Pentamethyleneamine
- piperdine
- Piperidine, homopolymer
- azinane
- Piperidine, puriss. p.a., >=99.0% (GC/T)
- piperadine
- pyperidine
- N-piperidine
- Piperidine [UN2401] [Corrosive]
- Piperidine, 99%
- TOLPERISONE_met028
- Piperidine on Rasta Resin
- Piperidine (Peptide Grade)
- Piperidine, >=99%, FG
- Piperidine, >=99%, FCC
Show all 31 synonymsShow fewer synonyms
- Piperidine, analytical standard
- Piperidine (Peptide Grade), 99%
- Piperidine, ReagentPlus(R), 99%
- UN 2401
- Piperidine, biotech. grade, >=99.5%
- Piperidine, purum, >=96.0% (GC/T)
Physical and chemical properties
Measured values and descriptors computed from the structure
Physical and chemical properties
Measured values, check the supplier specification for your grade
| Appearance | Clear, colorless liquidexp.Measured value |
|---|---|
| Odour | AMINE-LIKE ODORexp.Measured value |
| Taste | BURNING PEPPERY TASTEexp.Measured value |
| Melting point | -7 °Cexp.Measured value |
| Boiling point | 106 °Cexp.Measured value |
| Density | Relative density (water = 1): 0.86exp.Measured value |
| Flash point | 16 °Cexp.Measured value |
| Solubility | Miscible in waterexp.Measured value |
| Vapour pressure | VP: 40 mm Hg at 29.2 °Cexp.Measured value |
Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.
Computed descriptors
Calculated from the structure, useful for screening and formulation
| Molecular weight | 85.15 g/molcalc.Computed value |
|---|---|
| Exact mass | 85.0891 Dacalc.Computed value |
| LogP (octanol/water) | 0.76calc.Computed value |
| Topological polar surface area | 12.03 Ųcalc.Computed value |
| Hydrogen bond donors | 1calc.Computed value |
| Hydrogen bond acceptors | 1calc.Computed value |
| Rotatable bonds | 0calc.Computed value |
| Heavy atoms | 6calc.Computed value |
| Rings | 1calc.Computed value |
| Aromatic rings | 0calc.Computed value |
| Fraction sp3 carbons | 1calc.Computed value |
| Formal charge | 0calc.Computed value |
| Stereocentres | 0calc.Computed value |
| Lipinski rule of five | Passes (0 violations)calc.Computed value |
Calculated for screening. Confirm critical figures with the supplier.
Murcko scaffold
The ring system that remains when every side chain is removed
C1CCNCC1
1 ring, 6 atoms. This chemical is the scaffold itself.
32,085 other chemicals share this scaffoldSafety and hazards
GHS classification summary, not a safety data sheet
Hazard statements
- H225Highly flammable liquid and vapour.
- H311Toxic in contact with skin.
- H314Causes severe skin burns and eye damage.
- H331Toxic if inhaled.
Precautionary statements (28)
- P210Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
- P233Keep container tightly closed.
- P240Ground and bond container and receiving equipment.
- P241Use explosion-proof electrical, ventilating and lighting equipment.
- P242Use non-sparking tools.
- P243Take action to prevent static discharges.
- P260Do not breathe dust, fume, gas, mist, vapours or spray.
- P261Avoid breathing dust, fume, gas, mist, vapours or spray.
- P262Do not get in eyes, on skin, or on clothing.
- P264Wash skin thoroughly after handling.
- P270Do not eat, drink or smoke when using this product.
- P271Use only outdoors or in a well-ventilated area.
- P280Wear protective gloves, protective clothing, eye protection and face protection.
- P301 + P330 + P331If swallowed: Rinse mouth. Do not induce vomiting.
- P302 + P352If on skin: Wash with plenty of water.
- P302 + P361 + P354If on skin: Take off immediately all contaminated clothing. Immediately rinse with water for several minutes.
- P303 + P361 + P353If on skin (or hair): Take off immediately all contaminated clothing. Rinse skin with water or shower.
- P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
- P305 + P354 + P338If in eyes: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
- P316Get emergency medical help immediately.
- P321Specific treatment (see supplemental first aid instructions on the label).
- P361 + P364Take off immediately all contaminated clothing. And wash it before reuse.
- P363Wash contaminated clothing before reuse.
- P370 + P378In case of fire: Use appropriate media to extinguish.
- P403 + P233Store in a well-ventilated place. Keep container tightly closed.
- P403 + P235Store in a well-ventilated place. Keep cool.
- P405Store locked up.
- P501Dispose of contents and container in accordance with local regulations.
- UN number
- UN 2401
- Transport hazard class
- 8
- Packing group
- I
GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.
Full safety data and first aidPiperidine suppliers
Controlled substance, listings of documented suppliers only, in the documented ranking
Piperidine is controlled. Only documented suppliers can list it, and buyers must upload a valid licence with their request. Every request is reviewed before suppliers see it.
Reference: UN Convention against Illicit Traffic 1988 Table II, India NDPS controlled substance, HS 2022 subheading 2933.32 (piperidine)
Our policy on controlled substancesLicensed buyers can post a request for Piperidine with their licence. Our compliance team reviews it before suppliers see it.
Piperidine price
Indicative price range per kg from live supplier offers
Suppliers quote this chemical on request. Send one free request and compare quotes side by side.
Uses and applications
What the substance is used for, by industry and function
Prepn of crystalline derivatives of aromatic nitro compd containing nuclear halogen atoms.
Solvent and intermediate, curing agent for rubber and epoxy resins, catalyst for condensation reactions, ingredient in oils and fuels, complexing agent.
Used in the manufacture of local anesthetics, analgesics and other pharmaceuticals, and for wetting agents and germicides.
Intermediate for rubber vulcanization accelerators, hardening agent for epoxy resins.
Industrial uses: Intermediate, Laboratory chemicals, Processing aids not otherwise specified.
Pharmacological actions
- Calcium Channel Blockers
Roles
- Bronsted acid
- acid
- animal metabolite
- base
- catalyst
- donor
- eukaryotic metabolite
- human metabolite
- mammalian metabolite
- metabolite
- non-polar solvent
- plant metabolite
- polar solvent
- protic solvent
- reagent
- solvent
Functional uses
- Flavouring and nutrient
- Fragrance
How it is made
May be obtained from piperine by heating with alcoholic potassium hydroxide, or from 1,5-diaminopentane hydrochloride by cyclization. Usually prepared by electrolytic reduction of pyridine.
Usually prepared by electrolytic reduction of pyridine.
Piperidine and most of its derivatives are easily produced by hydrogenation of the corresponding pyridine derivatives at elevated temperature and pressure over nickel, palladium, or ruthenium catalysts.
Regulatory status
Inventories, regulations and trade controls that list this substance
Piperidine is controlled. Only documented suppliers can list it, and buyers must upload a valid licence with their request. Every request is reviewed before suppliers see it.
Reference: UN Convention against Illicit Traffic 1988 Table II, India NDPS controlled substance, HS 2022 subheading 2933.32 (piperidine)
Our policy on controlled substancesEurope
- EU harmonised classification (CLP Annex VI)Index no: 613-027-00-3
Controls
- US DEA controlled substance or listed chemical
- Drug precursor (UN 1988 Convention)
United States
- TSCA inventory (USA)Status: Active in US commerce
HS code and trade data
Customs classification and reported world trade statistics
Global trade
World import and export statistics for the HS code Piperidine is traded under.
Piperidine and its salts
- India * partner reported27.3%
- China15.4%
- United Kingdom14.4%
- Italy12.6%
- United States12.2%
- South Korea10.3%
* Partner reported figures, a lower bound.
The HS code shown for Piperidine is indicative (it was matched by name in the HS nomenclature). Confirm the classification with your customs broker before shipping.
Related chemicals
Parent and salt forms, stereoisomers, similar structures and isomers
Salt and hydrate forms
Records that share this compound as their parent
Stereoisomers and isotopic forms
Same connectivity, different stereochemistry or isotopes (same InChIKey skeleton)
Similar structures
Nearest neighbours by Morgan fingerprint Tanimoto similarity
Same formula isomers
Different compounds that share this molecular formula
Frequently asked questions
Quick answers about Piperidine, based on the data on this page
What is Piperidine?
What is the CAS number of Piperidine?
What is the molecular formula and weight of Piperidine?
What is Piperidine used for?
Is Piperidine hazardous?
What is the HS code of Piperidine?
Can I buy Piperidine on CompoundList?
Guides for buyers
Practical guides that help when you source, ship or handle Piperidine
- Guide, SafetyHow to read a safety data sheet in 10 minutesA section by section method to pull the essentials out of any 16 section SDS: identity, hazards, composition, storage, PPE, properties, transport and emergency measures.Read
- Guide, Trade and logisticsShipping dangerous goods: UN numbers, classes and packing groupsHow the UN dangerous goods system works for chemicals, from the nine classes and UN numbers to packing groups, UN packaging marks, labels, documents and segregation.Read
- Guide, SafetyGHS pictograms, signal words and hazard statements explainedA practical guide to the nine GHS pictograms, the signal words Danger and Warning, H and P statements, and how to read a chemical label in seconds.Read
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