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Heterocyclic building blocks

Pipobroman

Also known as Vercyte, Amedel, 1,4-Bis(3-bromopropionyl)piperazine

CAS 54-91-1Formula C10H16Br2N2O2Molar mass 356.06 g/molEC 620-535-9
GHS signal word: Danger. Pictograms: Harmful or irritant, Serious health hazard 11 suppliers listed
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Pipobroman chemical structure, C10H16Br2N2O2, CAS 54-91-1
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals
Melting point
106 to 107
Solubility
FREELY SOL IN CHLOROFORM, SOL IN METHANOL & ACETONE, SPARINGLY SOL IN ALC & BENZENE, SLI…
HS code
293359
Category
Heterocyclic building blocks
Illustrative photo, a shrink wrapped pallet of kraft paper sacks in a chemical plant
Typical packagingIllustrative packaging image, not the actual product

What is Pipobroman?

Plain description, key identifiers and synonyms

Pipobroman is an N-acylpiperazine that is piperazine in which each of the nitrogens has been acylated by a 3-bromopropionoyl group. An anti-cancer drug. It has a role as an alkylating agent and an antineoplastic agent. It is a tertiary carboxamide, an organobromine compound and a N-acylpiperazine.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
3-bromo-1-[4-(3-bromopropanoyl)piperazin-1-yl]propan-1-one
CAS number
54-91-1 CAS number cross-checked
EC number
620-535-9
Molecular formula
C10H16Br2N2O2
UNII
6Q99RDT97R
MDL number
MFCD00866372
InChIKey
NJBFOOCLYDNZJN-UHFFFAOYSA-N
InChI
InChI=1S/C10H16Br2N2O2/c11-3-1-9(15)13-5-7-14(8-6-13)10(16)2-4-12/h1-8H2
SMILES (canonical and isomeric)
C1CN(CCN1C(=O)CCBr)C(=O)CCBr

Synonyms

  • Vercyte
  • Amedel
  • 1,4-Bis(3-bromopropionyl)piperazine
  • Pipobromanum
  • Piperazine, 1,4-bis(3-bromo-1-oxopropyl)-
  • 3-bromo-1-[4-(3-bromopropanoyl)piperazin-1-yl]propan-1-one
  • N,N-Bis-(3-bromopropionyl)-piperazine
  • Piperazine, 1,4-bis(3-bromopropionyl)-
  • 3-bromo-1-(4-(3-bromopropanoyl)piperazin-1-yl)propan-1-one
  • 1,1'-(Piperazine-1,4-diyl)bis(3-bromopropan-1-one)
  • 1,4-Bis(3-bromopropanoyl)piperazine
  • N,N'-Bis(3-bromopropionyl)piperazine
  • C10H16Br2N2O2
  • Vercyte (tn)
  • Pipobroman (JAN/USAN/INN)
  • DivK1c_000799
  • Piperazine,4-bis(3-bromopropionyl)-
  • 1, 4-Bis(3-bromopropionyl)piperazine
  • 1,4-Bis(3-bromopropanoyl)piperazine #
  • Piperazine,4-bis(3-bromo-1-oxopropyl)-
  • 1,1'-piperazine-1,4-diylbis(3-bromopropan-1-one)
  • 1,1'-(1,4-Piperazinediyl)bis[3-bromo-1-propanone],

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystalsexp.
Odour
SLIGHTLY SHARP, FRUITY ODORexp.
Taste
SLIGHT BITTER TASTEexp.
Melting point
106 to 107exp.
Solubility
FREELY SOL IN CHLOROFORM, SOL IN METHANOL & ACETONE, SPARINGLY SOL IN ALC & BENZENE, SLIGHTLY SOL IN WATER, VERY SLIGHTLY SOL IN ETHERexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
356.06 g/molcalc.
Exact mass
353.9579 Dacalc.
LogP (octanol/water)
1.23calc.
Topological polar surface area
40.62 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
4calc.
Heavy atoms
16calc.
Rings
1calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.8calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1CNCCN1

C1CNCCN1

1 ring, 6 atoms, the Piperazine ring system.

6,832 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
  • H340May cause genetic defects.
  • H351Suspected of causing cancer.
Precautionary statements (18)
  • P203Obtain, read and follow all safety instructions before use.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Pipobroman suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 11 suppliers
11 of 11 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

11 suppliers in 3 countries

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Pipobroman price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Antineoplastic Agents, Alkylating

Roles

  • aetiopathogenetic role
  • alkylating agent
  • antineoplastic agent
  • genotoxin
  • mutagen
  • pharmaceutical

Pharmacology

Pipobroman is a piperazine derivative with potential antineoplastic alkyating activity. Although the exact mechanism of action of pipobroman has yet to be fully elucidated, this agent appears to act by alkylating DNA, leading to disruption of DNA replication and eventually cell death.

How it is made

Structure-cytostatic effect studies.

Piperazine, in dry chloroform solution, is doubly condensed with 3-bromopropionyl chloride using excess of piperazine to encourage dehydrochlorination. Crude product is crystallized from isopropyl alcohol.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Pipobroman is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Pipobroman is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Pipobroman, based on the data on this page

What is Pipobroman?

Pipobroman is an N-acylpiperazine that is piperazine in which each of the nitrogens has been acylated by a 3-bromopropionoyl group. An anti-cancer drug. It has a role as an alkylating agent and an antineoplastic agent. It is a tertiary carboxamide, an organobromine compound and a N-acylpiperazine.

What is the CAS number of Pipobroman?

The CAS registry number of Pipobroman is 54-91-1.

What is the molecular formula and weight of Pipobroman?

The molecular formula of Pipobroman is C10H16Br2N2O2 and its molar mass is 356.06 g/mol.

What is Pipobroman used for?

Known uses and roles of Pipobroman include building blocks in research and laboratory, aetiopathogenetic role, alkylating agent, antineoplastic agent, genotoxin and 3 more.

Is Pipobroman hazardous?

Pipobroman carries the GHS signal word "Danger". Main hazards: causes skin irritation, causes serious eye irritation, may cause respiratory irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Pipobroman?

Pipobroman is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Pipobroman?

CompoundList lists 11 suppliers of Pipobroman in China, United States and Germany. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Pipobroman?

Suppliers quote Pipobroman on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Pipobroman

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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