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Cardiovascular and metabolic drugs

Probucol

Also known as Lorelco, Biphenabid, Bisphenabid

CAS 23288-49-5Formula C31H48O2S2Molar mass 516.86 g/molEC 245-560-9
GHS signal word: Warning. Pictograms: Harmful or irritant 91 suppliers listed
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Probucol chemical structure, C31H48O2S2, CAS 23288-49-5
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
23288-49-5
Formula
C31H48O2S2
Molar mass
516.86 g/mol
EC number
245-560-9
HS code
293090
Category
Cardiovascular and metabolic drugs

What is Probucol?

Plain description, key identifiers and synonyms

Probucol is a dithioketal that is propane-2,2-dithiol in which the hydrogens attached to both sulfur atoms are replaced by 3,5-di-tert-butyl-4-hydroxyphenyl groups. An anticholesteremic drug with antioxidant and anti-inflammatory properties, it is used to treat high levels of cholesterol in blood. It has a role as an antioxidant, an anti-inflammatory drug, a cardiovascular drug, an antilipemic drug and an anticholesteremic drug. It is a polyphenol and a dithioketal.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2,6-ditert-butyl-4-[2-(3,5-ditert-butyl-4-hydroxyphenyl)sulfanylpropan-2-ylsulfanyl]phenol
CAS number
23288-49-5 CAS number cross-checked
EC number
245-560-9
Molecular formula
C31H48O2S2
UNII
P3CTH044XJ
MDL number
MFCD00079281
InChIKey
FYPMFJGVHOHGLL-UHFFFAOYSA-N
InChI
InChI=1S/C31H48O2S2/c1-27(2,3)21-15-19(16-22(25(21)32)28(4,5)6)34-31(13,14)35-20-17-23(29(7,8)9)26(33)24(18-20)30(10,11)12/h15-18,32-33H,1-14H3
SMILES (canonical and isomeric)
CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)SC(C)(C)SC2=CC(=C(C(=C2)C(C)(C)C)O)C(C)(C)C

Synonyms

  • Lorelco
  • Biphenabid
  • Bisphenabid
  • Bisbid
  • Lurselle
  • Sinlestal
  • Probucolum
  • DH 581
  • Acetone bis(3,5-di-tert-butyl-4-hydroxyphenyl) mercaptole
  • 4,4'-(Isopropylidenedithio)bis(2,6-di-tert-butylphenol)
  • 2,6-ditert-butyl-4-[2-(3,5-ditert-butyl-4-hydroxyphenyl)sulfanylpropan-2-ylsulfanyl]phenol
  • Phenol, 4,4'-[(1-methylethylidene)bis(thio)]bis[2,6-bis(1,1-dimethylethyl)-
  • 2,6-di-tert-butyl-4-({2-[(3,5-di-tert-butyl-4-hydroxyphenyl)sulfanyl]propan-2-yl}sulfanyl)phenol
  • Phenol, 4,4'-((1-methylethylidene)bis(thio))bis(2,6-bis(1,1-dimethylethyl)-
  • 4,4'-(Isopropylidenedithio)bis[2,6-di-tert-butylphenol]
  • probucolo
  • 2,6-ditert-butyl-4-(2-(3,5-ditert-butyl-4-hydroxyphenyl)sulfanylpropan-2-ylsulfanyl)phenol
  • 2,6-di-tert-butyl-4-((2-((3,5-di-tert-butyl-4-hydroxyphenyl)sulfanyl)propan-2-yl)sulfanyl)phenol
  • 4,4'-(Propan-2,2-diylbis(sulfandiyl))bis(2,6-bis(1,1-dimethylethyl)phenol)
  • Phenol, 4,4'-((1-methylethylidene)bis(thio))bis(2,6-bis(1,1-dimethylethyl))-
  • Lesterol
  • Lursell
  • Panavir
  • 4,4'-(propane-2,2-diylbis(sulfanediyl))bis(2,6-di-tert-butylphenol)
  • Lorelco (tn)
Show all 36 synonyms
  • Acetone, bis(3,5-di-tert-butyl-4-hydroxyphenyl) mercaptole
  • Probucol (Standard)
  • 4,4'-(propane-2,2-diyldisulfanediyl)bis(2,6-di-tert-butylphenol)
  • 4,4'-[(1-Methylethylidene)bis(thio)]bis-[2,6-bis(1,1-dimethylethyl)phenol]
  • 4,4'-(Isopropylidenedithio)bis(2, 6-di-tert-butylphenol)
  • 4,4'-(Isopropylidenedithio)bis[2, 6-di-tert-butylphenol]
  • Superlipid
  • 4,4'- (Isopropylidenedithio)bis(2,6-di-tert-butylphenol)
  • 2,6-bis(tert-butyl)-4-{1-[3,5-bis(tert-butyl)-4-hydroxyphenylthio]-isopropylth io}phenol
  • 2,6-ditert-butyl-4-[1-(3,5-ditert-butyl-4-hydroxy-phenyl)sulfanyl-1-methyl-ethyl]sulfanyl-phenol
  • Serterol

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
516.86 g/molcalc.
Exact mass
516.3096 Dacalc.
LogP (octanol/water)
9.91calc.
Topological polar surface area
40.46 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
4calc.
Heavy atoms
35calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.61calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Fails (2 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(SCSc2ccccc2)cc1

c1ccc(SCSc2ccccc2)cc1

2 rings, 15 atoms, the 1,1'-(Methylenebis(thio))bis(benzene) ring system.

92 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (16)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Probucol suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 91 suppliers
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Where suppliers are based

91 suppliers in 16 countries

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Probucol price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Anticholesteremic Agents
  • Antioxidants

Roles

  • anti-inflammatory agent
  • anti-inflammatory drug
  • anticholesteremic drug
  • antilipemic drug
  • antioxidant
  • cardiovascular drug
  • hypoglycemic agent
  • pharmaceutical

Pharmacology

Probucol is a bis-phenol antioxidant with antilipidemic activity. Probucol inhibits oxidation of low density lipoprotein and lowers the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Probucol is traded under.

HS 2930.90Indicative HS code

Organo-sulphur compounds, other

World exports in 2024
$5.83B
+0.1% vs 2023, imports $5.93B
2019 to 2024
Top exporters
  1. China40.7%
  2. United States10.9%
  3. Japan9.3%
Top importers
  1. United States13.3%
  2. Brazil12.6%
  3. China6.6%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Probucol is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Probucol, based on the data on this page

What is Probucol?

Probucol is a dithioketal that is propane-2,2-dithiol in which the hydrogens attached to both sulfur atoms are replaced by 3,5-di-tert-butyl-4-hydroxyphenyl groups. An anticholesteremic drug with antioxidant and anti-inflammatory properties, it is used to treat high levels of cholesterol in blood.

What is the CAS number of Probucol?

The CAS registry number of Probucol is 23288-49-5.

What is the molecular formula and weight of Probucol?

The molecular formula of Probucol is C31H48O2S2 and its molar mass is 516.86 g/mol.

What is Probucol used for?

Known uses and roles of Probucol include anti-inflammatories in pharmaceuticals, cardiovascular drugs in pharmaceuticals, polymer antioxidants in plastics and polymers, anti-inflammatory agent, anti-inflammatory drug and 8 more.

Is Probucol hazardous?

Probucol carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation, may cause respiratory irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Probucol?

Probucol is usually classified under HS code 293090 (Organo-sulphur compounds, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Probucol?

CompoundList lists 91 suppliers of Probucol in United States, China, United Kingdom, Spain and 12 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Probucol in India?

1 supplier in India list Probucol on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Probucol?

Suppliers quote Probucol on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Probucol

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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