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Murcko scaffold

1,1'-(Methylenebis(thio))bis(benzene) scaffold

93 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
15
Chemicals
93
With full pages
6
Scaffold SMILES

c1ccc(SCSc2ccccc2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1,1'-(Methylenebis(thio))bis(benzene) page
Murcko scaffold c1ccc(SCSc2ccccc2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 93 chemicals

Probucol chemical structure, C31H48O2S2, CAS 23288-49-5
Probucol
CAS 23288-49-5C31H48O2S2
1,1'-(Methylenebis(thio))bis(benzene) chemical structure, C13H12S2, CAS 3561-67-9
1,1'-(Methylenebis(thio))bis(benzene)
CAS 3561-67-9C13H12S2
Benzenamine, 2,2'-(methylenebis(thio))bis- chemical structure, C13H14N2S2, CAS 57491-68-6
Benzenamine, 2,2'-(methylenebis(thio))bis-
CAS 57491-68-6C13H14N2S2
Mdl 29311 chemical structure, C29H44O2S2, CAS 129895-82-5
Mdl 29311
CAS 129895-82-5C29H44O2S2
Bis(4-chlorophenylthio)methane chemical structure, C13H10Cl2S2, CAS 2393-97-7
Bis(4-chlorophenylthio)methane
CAS 2393-97-7C13H10Cl2S2
Mdl 27968 chemical structure, C19H24O2S2, CAS 27428-13-3
Mdl 27968
CAS 27428-13-3C19H24O2S2
Butyric acid, 3,3-bis((p-(1-carboxy-1-methylethoxy)phenyl)thio)- chemical structure, C24H28O8S2, CAS 99661-82-2
Butyric acid, 3,3-bis((p-(1-carboxy-1-methylethoxy)phenyl)thio)-
CAS 99661-82-2C24H28O8S2
Succinobucol chemical structure, C35H52O5S2, CAS 216167-82-7
Succinobucol
CAS 216167-82-7C35H52O5S2
Bis((4-chlorophenyl)thio)acetic acid chemical structure, C14H10Cl2O2S2, CAS 92153-25-8
Bis((4-chlorophenyl)thio)acetic acid
CAS 92153-25-8C14H10Cl2O2S2
5,5-Bis(phenylsulfanyl)pentane-1,2,3,4-tetrol chemical structure, C17H20O4S2, CAS 28697-82-7
5,5-Bis(phenylsulfanyl)pentane-1,2,3,4-tetrol
CAS 28697-82-7C17H20O4S2
Bis[(4-methylphenyl)sulfanyl]acetic acid chemical structure, C16H16O2S2, CAS 17067-32-2
Bis[(4-methylphenyl)sulfanyl]acetic acid
CAS 17067-32-2C16H16O2S2
Bis(p-tolylthio)methane chemical structure, C15H16S2, CAS 17241-04-2
Bis(p-tolylthio)methane
CAS 17241-04-2C15H16S2
Bis(3,4-dichlorophenylthio)methane chemical structure, C13H8Cl4S2, CAS 106241-40-1
Bis(3,4-dichlorophenylthio)methane
CAS 106241-40-1C13H8Cl4S2
Bis[(4-bromophenyl)thio]methane chemical structure, C13H10Br2S2, CAS 2393-98-8
Bis[(4-bromophenyl)thio]methane
CAS 2393-98-8C13H10Br2S2
Ethyl 2,2-bis((4-chlorophenyl)thio)-3-oxobutanoate chemical structure, C18H16Cl2O3S2, CAS 380344-03-6
Ethyl 2,2-bis((4-chlorophenyl)thio)-3-oxobutanoate
CAS 380344-03-6C18H16Cl2O3S2
Diethyl 2,2-bis((4-chlorophenyl)thio)malonate chemical structure, C19H18Cl2O4S2, CAS 76000-59-4
Diethyl 2,2-bis((4-chlorophenyl)thio)malonate
CAS 76000-59-4C19H18Cl2O4S2
(2-Methyl-1-phenylsulfanylpropyl)sulfanylbenzene chemical structure, C16H18S2, CAS 54905-13-4
(2-Methyl-1-phenylsulfanylpropyl)sulfanylbenzene
CAS 54905-13-4C16H18S2
Acetamide, 2,2-bis(p-tolylthio)- chemical structure, C16H17NOS2, CAS 73664-35-4
Acetamide, 2,2-bis(p-tolylthio)-
CAS 73664-35-4C16H17NOS2
Propionic acid, 2,2'-((1-methylethylidenedithio)bis(p-phenyleneoxy))bis(2-methyl- chemical structure, C23H28O6S2, CAS 99661-85-5
Propionic acid, 2,2'-((1-methylethylidenedithio)bis(p-phenyleneoxy))bis(2-methyl-
CAS 99661-85-5C23H28O6S2
Propanoic acid, 2-(4-((1-((4-hydroxyphenyl)thio)-1-methylethyl)thio)phenoxy)-2-methyl-, ethyl ester chemical structure, C21H26O4S2, CAS 99661-86-6
Propanoic acid, 2-(4-((1-((4-hydroxyphenyl)thio)-1-methylethyl)thio)phenoxy)-2-methyl-, ethyl ester
CAS 99661-86-6C21H26O4S2
Propionic acid, 2-(p-((1-((p-hydroxyphenyl)thio)-1-methylethyl)thio)phenoxy)-2-methyl- chemical structure, C19H22O4S2, CAS 99661-87-7
Propionic acid, 2-(p-((1-((p-hydroxyphenyl)thio)-1-methylethyl)thio)phenoxy)-2-methyl-
CAS 99661-87-7C19H22O4S2
Bis[(4-chlorophenyl)thiomethylene]biphosphonic Acid, Tetraisopropyl Ester chemical structure, C25H36Cl2O6P2S2, CAS 887353-24-4
Bis[(4-chlorophenyl)thiomethylene]biphosphonic Acid, Tetraisopropyl Ester
CAS 887353-24-4C25H36Cl2O6P2S2
Camobucol chemical structure, C33H50O4S2, CAS 216167-92-9
Camobucol
CAS 216167-92-9C33H50O4S2
Pentanedioic acid mono-{2,6-di-tert-butyl-4-[1-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-1-methyl-ethylsulfanyl]-phenyl} ester chemical structure, C36H54O5S2, CAS 216167-94-1
Pentanedioic acid mono-{2,6-di-tert-butyl-4-[1-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-1-methyl-ethylsulfanyl]-phenyl} ester
CAS 216167-94-1C36H54O5S2