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Cardiovascular and metabolic drugs

Procainamide

Also known as Novocainamide, Procaine amide, 4-Amino-N-[2-(diethylamino)ethyl]benzamide

CAS 51-06-9Formula C13H21N3OMolar mass 235.33 g/molEC 200-078-8
GHS signal word: Warning. Pictograms: Harmful or irritant 63 suppliers listed Drug substance
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Procainamide chemical structure, C13H21N3O, CAS 51-06-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
51-06-9
Formula
C13H21N3O
Molar mass
235.33 g/mol
Solubility
INSOL IN PETROLEUM ETHER /HYDROCHLORIDE SALT/
HS code
292429
Category
Cardiovascular and metabolic drugs

What is Procainamide?

Plain description, key identifiers and synonyms

Procainamide is a benzamide that is 4-aminobenzamide substituted on the amide N by a 2-(diethylamino)ethyl group. It is a pharmaceutical antiarrhythmic agent used for the medical treatment of cardiac arrhythmias. It has a role as an anti-arrhythmia drug, a sodium channel blocker and a platelet aggregation inhibitor.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-amino-N-[2-(diethylamino)ethyl]benzamide
CAS number
51-06-9 CAS number cross-checked
EC number
200-078-8
Molecular formula
C13H21N3O
UNII
L39WTC366D
MDL number
MFCD00066880
InChIKey
REQCZEXYDRLIBE-UHFFFAOYSA-N
InChI
InChI=1S/C13H21N3O/c1-3-16(4-2)10-9-15-13(17)11-5-7-12(14)8-6-11/h5-8H,3-4,9-10,14H2,1-2H3,(H,15,17)
SMILES (canonical and isomeric)
CCN(CC)CCNC(=O)C1=CC=C(C=C1)N

Synonyms

  • Novocainamide
  • Procaine amide
  • 4-Amino-N-[2-(diethylamino)ethyl]benzamide
  • Novocamid
  • Novocaine amide
  • Novocainamid
  • Biocoryl
  • Procamide
  • Procainamida
  • Procainamidum
  • p-Aminobenzoic diethylaminoethylamide
  • p-Amino-N-(2-diethylaminoethyl)benzamide
  • 4-Amino-N-(2-(diethylamino)ethyl)benzamide
  • Sp 100 (pharmaceutical)
  • Benzamide, 4-amino-N-(2-(diethylamino)ethyl)-
  • Benzamide, p-amino-N-(2-(diethylamino)ethyl)-
  • Benzamide, 4-amino-N-[2-(diethylamino)ethyl]-
  • Benzamide, p-amino-N-[2-(diethylamino)ethyl]-
  • Amide, Procaine
  • novocainamidum (for the hydrochloride)
  • 4-amino-N-(2-diethylaminoethyl)benzamide
  • Pronestyl
  • Procapan (free base)
  • Procan
  • Procainamide (INN)
Show all 31 synonyms
  • 2-Diethylaminoethylamid kyseliny p-aminobenzoove
  • Procanbid, SP 100, SP 100 (pharmaceutical)
  • Rhythmin
  • (4-aminophenyl)-N-[2-(diethylamino)ethyl]carboxamide
  • 4-amino-N-(2-diethylaminoethyl) benzamide
  • Cambridge id 5144127

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Solubility
INSOL IN PETROLEUM ETHER /HYDROCHLORIDE SALT/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
235.33 g/molcalc.
Exact mass
235.1685 Dacalc.
LogP (octanol/water)
1.34calc.
Topological polar surface area
58.36 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
6calc.
Heavy atoms
17calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.46calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccccc1

c1ccccc1

1 ring, 6 atoms, the Benzene ring system.

485,677 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (19)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Procainamide suppliers

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All 63 suppliers
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

63 suppliers in 15 countries

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Procainamide price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Veterinary medication:.

Use classes: Pharmaceuticals.

Pharmacological actions

  • Anti-Arrhythmia Agents
  • Voltage-Gated Sodium Channel Blockers

Roles

  • anti-arrhythmia drug
  • biophysical role
  • cardiovascular drug
  • hematologic agent
  • membrane transport modulator
  • pharmaceutical
  • platelet aggregation inhibitor
  • sodium channel blocker
  • sodium channel modulator

Pharmacology

Procainamide is an Antiarrhythmic.

How it is made

By condensing p-nitrobenzoyl chloride with beta-diethylaminoethylamine & then reducing nitro group to amino by any of usual methods. Hydrochloride forms readily when stream of hydrogen chloride is passed into solution of base in appropriate organic solvent. (Hydrochloride salt)

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: Procainamide (INN), its salts and derivatives, Ref no: 25, Annex ref: II/25
  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Procainamide is traded under.

HS 2924.29Indicative HS code

Cyclic amides (including cyclic carbamates) and their derivatives, salts thereof, other

World exports in 2024
$5.69B
−5.1% vs 2023, imports $5.8B
2019 to 2024
Top exporters
  1. China32.3%
  2. Switzerland * partner reported13.6%
  3. Norway * partner reported12.8%
Top importers
  1. United States15.9%
  2. Ireland15.8%
  3. Germany11.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Procainamide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Procainamide, based on the data on this page

What is Procainamide?

Procainamide is a benzamide that is 4-aminobenzamide substituted on the amide N by a 2-(diethylamino)ethyl group. It is a pharmaceutical antiarrhythmic agent used for the medical treatment of cardiac arrhythmias. It has a role as an anti-arrhythmia drug, a sodium channel blocker and a platelet aggregation inhibitor.

What is the CAS number of Procainamide?

The CAS registry number of Procainamide is 51-06-9.

What is the molecular formula and weight of Procainamide?

The molecular formula of Procainamide is C13H21N3O and its molar mass is 235.33 g/mol.

What is Procainamide used for?

Veterinary medication:. Use classes: Pharmaceuticals.

Is Procainamide hazardous?

Procainamide carries the GHS signal word "Warning". Main hazards: harmful if swallowed, causes skin irritation, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Procainamide?

Procainamide is usually classified under HS code 292429 (Cyclic amides (including cyclic carbamates) and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Procainamide?

CompoundList lists 63 suppliers of Procainamide in United States, China, Germany, Spain and 11 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Procainamide in India?

2 suppliers in India list Procainamide on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Procainamide?

Suppliers quote Procainamide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Procainamide

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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