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Hormones and steroids

Progesterone

Also known as Pregn-4-ene-3,20-dione, Agolutin, Progestin

CAS 57-83-0Formula C21H30O2Molar mass 314.47 g/molEC 200-350-6
GHS signal word: Danger. Pictograms: Serious health hazard, Hazardous to the environment 168 suppliers listed Drug substance
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Progesterone chemical structure, C21H30O2, CAS 57-83-0
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Prisms
Melting point
129 °C
Density
1.166 g/cm³ at 23 °C
Solubility
In double-distilled water, 9.12 mg/L
HS code
293723
Category
Hormones and steroids
Illustrative photo, closed blue fibre drums on a pallet in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Progesterone?

Plain description, key identifiers and synonyms

Progesterone is a C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species. It has a role as a contraceptive drug, a progestin, a progesterone receptor agonist, a mouse metabolite and a human metabolite. It is a 20-oxo steroid, a 3-oxo-Delta(4) steroid and a C21-steroid hormone. It derives from a hydride of a pregnane.

Progesterone is a sex hormone.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
CAS number
57-83-0 CAS number cross-checkedOther or deprecated CAS: 137940-28-4
EC number
200-350-6
Molecular formula
C21H30O2
UNII
4G7DS2Q64Y
MDL number
MFCD00003658
INCI name
PROGESTERONE
InChIKey
RJKFOVLPORLFTN-LEKSSAKUSA-N
InChI
InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1
Canonical SMILES
CC(=O)C1CCC2C3CCC4=CC(=O)CCC4(C)C3CCC12C
Isomeric SMILES
CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C

Synonyms

  • Pregn-4-ene-3,20-dione
  • Agolutin
  • Progestin
  • Crinone
  • Utrogestan
  • Luteol
  • Gestormone
  • Glanducorpin
  • Syngesterone
  • Cyclogest
  • Gestone
  • 4-Pregnene-3,20-dione
  • Corlutina
  • Corluvite
  • Flavolutan
  • Fologenon
  • Gynolutone
  • Hormoflaveine
  • Hormoluton
  • Lucorteum
  • Luteostab
  • Lutociclina
  • Lutocyclin
  • Pregnenedione
  • Progestasert
Show all 39 synonyms
  • Progesterol
  • Progesteronum
  • Progestone
  • Progestron
  • Prometrium
  • Corlutin
  • Corporin
  • Gesterol
  • Gestron
  • Gynlutin
  • Luteodyn
  • Luteogan
  • Luteopur
  • Luteosan

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Prismsexp.
Odour
Odorlessexp.
Melting point
129 °Cexp.
Density
1.166 g/cm³ at 23 °Cexp.
Solubility
In double-distilled water, 9.12 mg/Lexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
314.47 g/molcalc.
Exact mass
314.2246 Dacalc.
LogP (octanol/water)
4.72calc.
Topological polar surface area
34.14 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
1calc.
Heavy atoms
23calc.
Rings
4calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.81calc.
Formal charge
0calc.
Stereocentres
6calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1C=C2CCC3C4CCCC4CCC3C2CC1

O=C1C=C2CCC3C4CCCC4CCC3C2CC1

4 rings, 18 atoms.

1,419 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS08: Serious health hazard
Serious health hazard
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H350May cause cancer.
  • H351Suspected of causing cancer.
  • H360May damage fertility or the unborn child.
  • H360FDMay damage fertility. May damage the unborn child.
  • H361Suspected of damaging fertility or the unborn child.
  • H362May cause harm to breast-fed children.
  • H410Very toxic to aquatic life with long lasting effects.
Precautionary statements (11)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P263Avoid contact during pregnancy and while nursing.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P318If exposed or concerned, get medical advice.
  • P391Collect spillage.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Progesterone suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 168 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

168 suppliers in 20 countries

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Progesterone price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

A food additive permitted in the feed and drinking water of animals and/or for the treatment of food-producing animals. Also permitted in food for human consumption.

Lab reagent.

Veterinary medication:.

Use classes: Pharmaceuticals, Animal Drugs.

Cosmetic ingredient, INCI name PROGESTERONE(skin conditioning)

Pharmacological actions

  • Neurosteroids
  • Progestins

Roles

  • anti-HIV agent
  • anticoagulant
  • anticonvulsant
  • antidepressant
  • antihypertensive agent
  • antineoplastic agent
  • antiviral agent
  • appetite enhancer
  • appetite regulator
  • bone density conservation agent
  • cardiovascular drug
  • central nervous system drug
  • contraceptive drug
  • hematologic agent
  • hormone agonist
  • hormone receptor modulator
  • human metabolite
  • hypoglycemic agent
  • mouse metabolite
  • neuroprotective agent
  • pharmaceutical
  • progesterone receptor agonist
  • progestin
  • protective agent

Functional uses

  • Softener and conditioner

Cosmetic functions

  • Skin conditioning

Pharmacology

Progesterone is a Progesterone.

How it is made

From animal ovaries, synthesized from stigmasterol, or better from diosgenin (extracted from Dioscorea mexicana, a Mexican yam). The latter synthesis involves acetolysis, chromic acid oxidation, cleavage of the ketoester diacetate with boiling acetic acid to 16-dehydropregnenolone acetate, which on catalytic reduction yields pregnenolone acetate. Saponification of the acetate ester to the 3beta-alcohol followed by Oppenauer oxidation affords progesterone.

Two methods are available for the preparation of progesterone: (1) Selective hydrogenation of dehydropregnenolone acetate, (2) The conversion of stigmasterol...

Isolation from corpus luteum of pregnant sows.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory
  • Active ingredient in FDA approved drug labels

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Progesterone is traded under.

HS 2937.23Indicative HS code

Oestrogens and progestogens

World exports in 2024
$762M
−2.3% vs 2023, imports $693M
2019 to 2024
Top exporters
  1. China42.9%
  2. Italy18.4%
  3. Netherlands8.9%
Top importers
  1. India * partner reported12.1%
  2. United States11.0%
  3. Belgium8.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Progesterone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Progesterone, based on the data on this page

What is Progesterone?

Progesterone is a C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.

What is the CAS number of Progesterone?

The CAS registry number of Progesterone is 57-83-0. Other or deprecated CAS numbers: 137940-28-4.

What is the molecular formula and weight of Progesterone?

The molecular formula of Progesterone is C21H30O2 and its molar mass is 314.47 g/mol.

What is Progesterone used for?

A food additive permitted in the feed and drinking water of animals and/or for the treatment of food-producing animals. Also permitted in food for human consumption. Lab reagent. Veterinary medication:. Use classes: Pharmaceuticals, Animal Drugs.

Is Progesterone hazardous?

Progesterone carries the GHS signal word "Danger". Main hazards: may cause cancer, suspected of causing cancer, may damage fertility or the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Progesterone?

Progesterone is usually classified under HS code 293723 (Oestrogens and progestogens). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Progesterone?

CompoundList lists 168 suppliers of Progesterone in China, United States, India, Germany and 16 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Progesterone in India?

26 suppliers in India list Progesterone on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Progesterone?

Suppliers quote Progesterone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Progesterone

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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