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Insecticides and acaricides

Prothiofos

Also known as Prothiophos, Tokuthion, Dichlorpropaphos

CAS 34643-46-4Formula C11H15Cl2O2PS2Molar mass 345.25 g/molEC 252-125-7
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant, Hazardous to the environment
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Prothiofos chemical structure, C11H15Cl2O2PS2, CAS 34643-46-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
34643-46-4
Formula
C11H15Cl2O2PS2
Molar mass
345.25 g/mol
EC number
252-125-7
HS code
293090
Category
Insecticides and acaricides

What is Prothiofos?

Plain description, key identifiers and synonyms

Prothiofos is an organic thiophosphate that is the 2,4-dichlorophenyl ester of O-ethyl S-propyl dithiophosphoric acid. It has a role as an insecticide, an agrochemical, an EC 3.1.1.8 (cholinesterase) inhibitor and an EC 3.1.1.7 (acetylcholinesterase) inhibitor. It is a dichlorobenzene, an organosulfur compound and an organic thiophosphate. It is functionally related to a 2,4-dichlorophenol.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2,4-dichlorophenoxy)-ethoxy-propylsulfanyl-sulfanylidene-λ5-phosphane
CAS number
34643-46-4 CAS number cross-checkedOther or deprecated CAS: 1246818-20-1
EC numbers
252-125-7, 685-654-0
Molecular formula
C11H15Cl2O2PS2
UNII
H5232196GP
InChIKey
FITIWKDOCAUBQD-UHFFFAOYSA-N
InChI
InChI=1S/C11H15Cl2O2PS2/c1-3-7-18-16(17,14-4-2)15-11-6-5-9(12)8-10(11)13/h5-6,8H,3-4,7H2,1-2H3
SMILES (canonical and isomeric)
CCCSP(=S)(OCC)OC1=C(C=C(C=C1)Cl)Cl

Synonyms

  • Prothiophos
  • Tokuthion
  • Dichlorpropaphos
  • Toyodan
  • BAY-NTN 8629
  • Phosphorodithioic acid, O-(2,4-dichlorophenyl) O-ethyl S-propyl ester
  • o-(2,4-Dichlorophenyl) o-ethyl S-propyl phosphorodithioate
  • O-(2,4-dichlorophenyl) O-ethyl S-propyl phosphorodithionate
  • Tukuthion
  • (rs)-(O-2,4-Dichlorophenyl o-ethyl S-propyl phosphorodithioate)
  • Bideron
  • BAY ntn 8629
  • Prothiofos-13C6
  • O-(2,4-Dichlorophenyl) O-ethyl S-propyl dithiophosphate
  • (2,4-dichlorophenoxy)-ethoxy-propylsulfanyl-sulfanylidene-lambda5-phosphane
  • Toyothion
  • NTN 8629,4541
  • O-(2,4-Dichlorophenyl) O-ethyl S-propylphosphorodithioate
  • O-Ethyl-O-(2,4-dichlorophenyl)-S-n-propyl-dithiophosphate
  • (+/-)-Prothiofos
  • Prothiofos, (+/-)-
  • Prothiophos 10 |Ig/mL in Cyclohexane
  • Prothiophos 10 |Ig/mL in Acetonitrile
  • Prothiophos 10 microg/mL in Cyclohexane
  • Prothiophos 10 microg/mL in Acetonitrile
Show all 29 synonyms
  • Prothiophos 100 microg/mL in Acetonitrile
  • Tokuthion, technical grade, pkg of 50 mg
  • Prothiofos, PESTANAL(R), analytical standard
  • o-(2,4-Dichlorophenyl) o-ethyl S-propyl dithiophosphate #

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
345.25 g/molcalc.
Exact mass
343.9628 Dacalc.
LogP (octanol/water)
5.78calc.
Topological polar surface area
18.46 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
7calc.
Heavy atoms
18calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.46calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccccc1

c1ccccc1

1 ring, 6 atoms, the Benzene ring system.

485,677 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H302Harmful if swallowed.
  • H330Fatal if inhaled.
  • H400Very toxic to aquatic life.
  • H410Very toxic to aquatic life with long lasting effects.
Precautionary statements (15)
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P273Avoid release to the environment.
  • P284In case of inadequate ventilation wear respiratory protection.
  • P301 + P317If swallowed: Get medical help.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P316Get emergency medical help immediately.
  • P320Specific treatment is urgent (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P391Collect spillage.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Prothiofos suppliers

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Prothiofos price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Roles

  • agrochemical
  • enzyme inhibitor
  • insecticide
  • pesticide

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Prothiofos is traded under.

HS 2930.90Indicative HS code

Organo-sulphur compounds, other

World exports in 2024
$5.83B
+0.1% vs 2023, imports $5.93B
2019 to 2024
Top exporters
  1. China40.7%
  2. United States10.9%
  3. Japan9.3%
Top importers
  1. United States13.3%
  2. Brazil12.6%
  3. China6.6%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Prothiofos is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Prothiofos, based on the data on this page

What is Prothiofos?

Prothiofos is an organic thiophosphate that is the 2,4-dichlorophenyl ester of O-ethyl S-propyl dithiophosphoric acid. It has a role as an insecticide, an agrochemical, an EC 3.1.1.8 (cholinesterase) inhibitor and an EC 3.1.1.7 (acetylcholinesterase) inhibitor.

What is the CAS number of Prothiofos?

The CAS registry number of Prothiofos is 34643-46-4. Other or deprecated CAS numbers: 1246818-20-1.

What is the molecular formula and weight of Prothiofos?

The molecular formula of Prothiofos is C11H15Cl2O2PS2 and its molar mass is 345.25 g/mol.

What is Prothiofos used for?

Use classes: Pharmaceuticals.

Is Prothiofos hazardous?

Prothiofos carries the GHS signal word "Danger". Main hazards: harmful if swallowed, fatal if inhaled, very toxic to aquatic life. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Prothiofos?

Prothiofos is usually classified under HS code 293090 (Organo-sulphur compounds, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Prothiofos?

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What is the price of Prothiofos?

Suppliers quote Prothiofos on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Prothiofos

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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