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Central nervous system drugs

Protriptyline

Also known as Protryptyline, Amimetilina, Triptil

CAS 438-60-8Formula C19H21NMolar mass 263.38 g/molEC 207-119-9
Drug substance
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Protriptyline chemical structure, C19H21N, CAS 438-60-8
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
438-60-8
Formula
C19H21N
Melting point
169 to 171 °C
Solubility
SOL: 1 G IN ABOUT 2 ML WATER, ABOUT 2 ML METHANOL, ABOUT 2.3 ML CHLOROFORM, ABOUT 4 ML A…
HS code
292149
Category
Central nervous system drugs

What is Protriptyline?

Plain description, key identifiers and synonyms

Protriptyline is a carbotricyclic compound. It has a role as an antidepressant. It derives from a hydride of a dibenzo[a,d][7]annulene.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-methyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaenyl)propan-1-amine
CAS number
438-60-8 CAS number cross-checked
EC number
207-119-9
Molecular formula
C19H21N
UNII
4NDU154T12
InChIKey
BWPIARFWQZKAIA-UHFFFAOYSA-N
InChI
InChI=1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-10,12-13,19-20H,6,11,14H2,1H3
SMILES (canonical and isomeric)
CNCCCC1C2=CC=CC=C2C=CC3=CC=CC=C13

Synonyms

  • Protryptyline
  • Amimetilina
  • Triptil
  • Protriptilina
  • Protriptylinum
  • 7-(3-Methylaminopropyl)-1,2:5,6-dibenzocycloheptatriene
  • N-Methyl-5H-dibenzo[a,d]cycloheptene-5-propanamine
  • N-Methyl-5H-dibenzo[a,d]cycloheptene-5-propylamine
  • 5-(3-Methylaminopropyl)-5H-Dibenzo[a,d]cycloheptene
  • N-3-(5H-Dibenzo(a,d)cyclohepten-5-yl)propyl-N-methylamine
  • 3-(5H-dibenzo[a,d][7]annulen-5-yl)-N-methylpropan-1-amine
  • N-Methyl-5H-dibenzo(a,d)cycloheptene-5-propylamine
  • 5-(3-Methylaminopropyl)-5H-dibenzo(a,d)cycloheptene
  • 5H-Dibenzo(a,d)cycloheptene-5-propanamine, N-methyl-
  • 5H-Dibenzo(a,d)cycloheptene-5-propylamine, N-methyl-
  • 3-(5H-Dibenzo[a,d]cyclohepten-5-yl)-N-methyl-1-propanamine
  • 5H-Dibenzo[a,d]cycloheptene-5-propanamine, N-methyl-
  • 3-(11H-dibenzo[1,2-a:1',2'-e][7]annulen-11-yl)-N-methylpropan-1-amine
  • 5H-Dibenzo(a,d)cycloheptene-5-propanamine, N-methyl-, hydrochloride
  • N-methyl-5H-dibenzo(a,d)cycloheptene-5-propanamine
  • 5H-Dibenzo[a,d]cycloheptene-5-propylamine, N-methyl-
  • 3-(5H-dibenzo(a,d)(7)annulen-5-yl)-N-methylpropan-1-amine
  • 3-(5H-dibenzo(a,d)cyclohepten-5-yl)-N-methyl-1-propanamine
  • 3-(11H-dibenzo(1,2-a:1',2'-e)(7)annulen-11-yl)-N-methylpropan-1-amine
  • methyl(3-(tricyclo(9.4.0.0^(3,8))pentadeca-1(11),3(8),4,6,9,12,14-heptaen-2-yl)propyl)amine
Show all 34 synonyms
  • methyl(3-{tricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,9,12,14-heptaen-2-yl}propyl)amine
  • Hydrochloride, Protriptyline
  • methyl(3-(tricyclo(9.4.0.03,8)pentadeca-1(15),3,5,7,9,11,13-heptaen-2-yl)propyl)amine
  • N-Methyl-5H-dibenzo(a,d)cycloheptene-5-propylamine hydrochloride
  • Vivactil
  • Vivactyl
  • Protriptyline (INN)
  • Protryptyline hydrochloride
  • N-methyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaenyl)propan-1-amine

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Melting point
169 to 171 °Cexp.
Solubility
SOL: 1 G IN ABOUT 2 ML WATER, ABOUT 2 ML METHANOL, ABOUT 2.3 ML CHLOROFORM, ABOUT 4 ML ALCOHOL, PRACTICALLY INSOL IN ETHER /HYDROCHLORIDE/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
263.38 g/molcalc.
Exact mass
263.1674 Dacalc.
LogP (octanol/water)
4.3calc.
Topological polar surface area
12.03 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
1calc.
Rotatable bonds
4calc.
Heavy atoms
20calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.26calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1=Cc2ccccc2Cc2ccccc21

C1=Cc2ccccc2Cc2ccccc21

3 rings, 15 atoms, the 5H-Dibenzo(a,d)cycloheptene ring system.

55 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Protriptyline suppliers

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Protriptyline price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Industries and functions

Pharmacological actions

  • Adrenergic Uptake Inhibitors
  • Antidepressive Agents, Tricyclic

Roles

  • antidepressant
  • central nervous system drug
  • pharmaceutical
  • psychotropic drug

Pharmacology

Protriptyline is a Tricyclic Antidepressant.

How it is made

Engelhardt, Christy, Belgian patent 617,967 (1962 to Merck & Co) CA 59, 517f (1963), Tishler et al, US patent 3,244,748 & 3,271,451 (both 1966 to Merck & Co), Engelhardt et al, J Med Chem 11, 325 (1968).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Protriptyline is traded under.

HS 2921.49Indicative HS code

Aromatic monoamines and their derivatives, salts thereof, other

World exports in 2024
$1.14B
+5.6% vs 2023, imports $1.06B
2019 to 2024
Top exporters
  1. Germany23.3%
  2. China19.4%
  3. Singapore14.6%
Top importers
  1. Belgium15.9%
  2. South Korea15.0%
  3. Germany12.8%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Protriptyline is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Protriptyline, based on the data on this page

What is Protriptyline?

Protriptyline is a carbotricyclic compound. It has a role as an antidepressant. It derives from a hydride of a dibenzo[a,d][7]annulene.

What is the CAS number of Protriptyline?

The CAS registry number of Protriptyline is 438-60-8.

What is the molecular formula and weight of Protriptyline?

The molecular formula of Protriptyline is C19H21N and its molar mass is 263.38 g/mol.

What is Protriptyline used for?

Use classes: Pharmaceuticals.

Is Protriptyline hazardous?

No GHS hazard classification for Protriptyline is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Protriptyline?

Protriptyline is usually classified under HS code 292149 (Aromatic monoamines and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Protriptyline?

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What is the price of Protriptyline?

Suppliers quote Protriptyline on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Protriptyline

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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