CompoundList
Sign in
Central nervous system drugs

Nortriptyline

Also known as Noramitriptyline, Desitriptilina, Ateben

CAS 72-69-5Formula C19H21NMolar mass 263.38 g/molEC 200-788-8
GHS signal word: Warning. Pictograms: Harmful or irritant 52 suppliers listed Drug substance
Get quotes Compare 52 suppliers
Nortriptyline chemical structure, C19H21N, CAS 72-69-5
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
72-69-5
Formula
C19H21N
Molar mass
263.38 g/mol
EC number
200-788-8
HS code
292149
Category
Central nervous system drugs

What is Nortriptyline?

Plain description, key identifiers and synonyms

Nortriptyline is an organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of amitriptyline. It has a role as an antidepressant, an analgesic, an antineoplastic agent, an adrenergic uptake inhibitor, a drug metabolite and an apoptosis inducer. It is a secondary amine and an organic tricyclic compound. It is functionally related to an amitriptyline. It derives from a hydride of a dibenzo[a,d][7]annulene.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-methyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amine
CAS number
72-69-5 CAS number cross-checkedOther or deprecated CAS: 894-71-3
EC number
200-788-8
Molecular formula
C19H21N
UNII
BL03SY4LXB
MDL number
MFCD00242775
InChIKey
PHVGLTMQBUFIQQ-UHFFFAOYSA-N
InChI
InChI=1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-11,20H,6,12-14H2,1H3
SMILES (canonical and isomeric)
CNCCC=C1C2=CC=CC=C2CCC3=CC=CC=C31

Synonyms

  • Noramitriptyline
  • Desitriptilina
  • Ateben
  • Avantyl
  • Lumbeck
  • Desmethylamitriptyline
  • Noritren
  • Sensaval
  • Demethylamitriptyline
  • Sesaval
  • Demethylamitryptyline
  • Nortryptiline
  • Nortryptyline
  • Nortriptilina
  • Nortriptylinum
  • Psychostyl
  • Nortrilen
  • Amitryptyline, demethyl-
  • 1-Propanamine, 3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N-methyl-
  • 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
  • N-methyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amine
  • 5-(3-Methylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptene
  • 5-(3-(Methylamino)propylidene)dibenzo(a,e)cyclohepta(1,5)diene
  • 5-(alpha-Methylaminopropylidene)dibenzo(a,d)cyclohepta(1,4)diene
  • N-Methyl-3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-yliden)propylamin
Show all 39 synonyms
  • 10,11-Dihydro-5-(3-methylaminopropylidene)-5H-dibenzo(a,d)(1,4)cycloheptene
  • 10,11-Dihydro-N-methyl-5H-dibenzo(a,d)cycloheptene-delta(5,gamma)-propylamine
  • 3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N-methylpropan-1-amine
  • 1-Propanamine, 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-
  • 5H-Dibenzo(a,d)cycloheptene-delta(sup 5),gamma-propylamine, 10,11-dihydro-N-methyl-
  • Desitriptyline
  • Desmethylamitriptylin
  • 10,11-dihydro-N-methyl-5H-dibenzo[a,d]cycloheptene-Delta(5,gamma)-propylamine
  • 3-(10,11-Dihydro-5H-dibenzo(a,d)(7)annulen-5-ylidene)-N-methylpropan-1-amine
  • methyl({3-[(2E)-tricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene]propyl})amine
  • 5-[3-(Methylamino)propylidene]dibenzo[a,E]cyclohepta[1,5]diene
  • Nu Nortriptyline
  • Apo Nortriptyline
  • Gen Nortriptyline

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
263.38 g/molcalc.
Exact mass
263.1674 Dacalc.
LogP (octanol/water)
3.83calc.
Topological polar surface area
12.03 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
1calc.
Rotatable bonds
3calc.
Heavy atoms
20calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.26calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C=C1c2ccccc2CCc2ccccc21

C=C1c2ccccc2CCc2ccccc21

3 rings, 16 atoms, the 5-Methylene-10,11-dihydro-5H-dibenzo[a,d][7]annulene ring system.

77 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
Precautionary statements (5)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P317If swallowed: Get medical help.
  • P330Rinse mouth.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Nortriptyline suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 52 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

52 suppliers in 14 countries

Send one request to many suppliers

Choose up to 10 suppliers or let us match your request. Compare quotes side by side, free.

Choose suppliersPost a request

Nortriptyline price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

Get latest price

Uses and applications

What the substance is used for, by industry and function

Adrenergic Uptake Inhibitors, Antidepressive Agents, Tricyclic.

Use classes: Pharmaceuticals, Transformation products.

Industries and functions

Pharmacological actions

  • Adrenergic Uptake Inhibitors
  • Antidepressive Agents, Tricyclic

Roles

  • adrenergic agent
  • adrenergic uptake inhibitor
  • analgesic
  • antidepressant
  • antineoplastic agent
  • antipsoriatic
  • antipsychotic agent
  • antispasmodic drug
  • anxiolytic drug
  • apoptosis inducer
  • central nervous system depressant
  • central nervous system drug
  • dermatologic drug
  • drug metabolite
  • eukaryotic metabolite
  • gastrointestinal drug
  • metabolite
  • muscle relaxant
  • neuromuscular agent
  • neurotransmitter agent
  • pharmaceutical
  • psychotropic drug
  • tranquilizing drug
  • xenobiotic metabolite

Pharmacology

Nortriptyline is a Tricyclic Antidepressant.

How it is made

Dibenzosuberone + cyclopropyl bromide + methylamine (Grignard reaction/rearrangement/amine formation)

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Nortriptyline is traded under.

HS 2921.49Indicative HS code

Aromatic monoamines and their derivatives, salts thereof, other

World exports in 2024
$1.14B
+5.6% vs 2023, imports $1.06B
2019 to 2024
Top exporters
  1. Germany23.3%
  2. China19.4%
  3. Singapore14.6%
Top importers
  1. Belgium15.9%
  2. South Korea15.0%
  3. Germany12.8%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Nortriptyline is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Nortriptyline, based on the data on this page

What is Nortriptyline?

Nortriptyline is an organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of amitriptyline.

What is the CAS number of Nortriptyline?

The CAS registry number of Nortriptyline is 72-69-5. Other or deprecated CAS numbers: 894-71-3.

What is the molecular formula and weight of Nortriptyline?

The molecular formula of Nortriptyline is C19H21N and its molar mass is 263.38 g/mol.

What is Nortriptyline used for?

Adrenergic Uptake Inhibitors, Antidepressive Agents, Tricyclic. Use classes: Pharmaceuticals, Transformation products.

Is Nortriptyline hazardous?

Nortriptyline carries the GHS signal word "Warning". Main hazards: harmful if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Nortriptyline?

Nortriptyline is usually classified under HS code 292149 (Aromatic monoamines and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Nortriptyline?

CompoundList lists 52 suppliers of Nortriptyline in United States, China, United Kingdom, Spain and 10 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Nortriptyline in India?

3 suppliers in India list Nortriptyline on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Nortriptyline?

Suppliers quote Nortriptyline on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Nortriptyline

Get quotes for Nortriptyline

Post one free request with your grade, quantity and destination. Matching suppliers send quotes you can compare side by side.
Post a request Sell Nortriptyline
Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
Embed this structure on your websiteShow code

Paste this code into your page to show the 2D structure of Nortriptyline with a 3D view, its CAS number where known and a link back to this page. Free to use with the link kept.

<iframe src="https://www.compoundlist.com/embed/structure/nortriptyline-72-69-5" title="Nortriptyline structure on CompoundList" width="360" height="420" style="border:1px solid #E7E2DA;border-radius:12px;max-width:100%" loading="lazy" referrerpolicy="strict-origin-when-cross-origin"></iframe>
Preview the embed

Explore more in Central nervous system drugs or HS code 292149

52 suppliers
Free quotes, contact stays private
Get quotes