CompoundList
Sign in
Pharmaceuticals and APIs

Protriptyline hydrochloride

Also known as Protriptyline HCl, Concordin, Maximed

CAS 1225-55-4Formula C19H22ClNMolar mass 299.85 g/molEC 214-956-3
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant 28 suppliers listed Drug substance
Get quotes Compare 28 suppliers
Protriptyline hydrochloride chemical structure, C19H22ClN, CAS 1225-55-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
1225-55-4
Formula
C19H22ClN
Molar mass
299.85 g/mol
EC number
214-956-3
HS code
292149
Category
Pharmaceuticals and APIs

What is Protriptyline hydrochloride?

Plain description, key identifiers and synonyms

Protriptyline Hydrochloride is the hydrochloride salt form of protriptyline, a tricyclic secondary amine with antidepressant property. Protriptyline hydrochloride blocks the re-uptake of norepinephrine and serotonin by nerve terminals, thereby increasing available norepinephrine and serotonin. Protriptyline does not block dopamine transport but may have an indirect dopamine-facilitating effect through interactions of increased peri-synaptic abundance of norepinephrine, particularly in the cerebral cortex, where adrenergic terminals exceed dopaminergic terminals. This results in elevation of mood and behavioral activity. In addition, this agent exhibits anticholinergic activity.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-methyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaenyl)propan-1-amine, hydrochloride
CAS number
1225-55-4 CAS number cross-checked
EC number
214-956-3
Molecular formula
C19H22ClN
UNII
44665V00O8
MDL number
MFCD00072057
InChIKey
OGQDIIKRQRZXJH-UHFFFAOYSA-N
InChI
InChI=1S/C19H21N.ClH/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19;/h2-5,7-10,12-13,19-20H,6,11,14H2,1H3;1H
SMILES (canonical and isomeric)
CNCCCC1C2=CC=CC=C2C=CC3=CC=CC=C13.Cl

Synonyms

  • Protriptyline HCl
  • Concordin
  • Maximed
  • Triptil hydrochloride
  • Concordin-5
  • Concordin-10
  • Triptyl
  • Protriptyline (hydrochloride)
  • Normethyl EX4442
  • Protriptyline.HCl
  • Vivactyl
  • 5H-Dibenzo[a,d]cycloheptene-5-propanamine, N-methyl-, hydrochloride (1:1)
  • N-methyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaenyl)propan-1-amine, hydrochloride
  • 5-(3-Methylaminopropyl)-5H-dibenzo(a,d)cycloheptene hydrochloride
  • Triptil (VAN)
  • 5-(3-Methylaminopropyl)-5H-dibenzo[a,d]cycloheptene hydrochloride
  • MK-240 (VAN)
  • Vivactil (TN)
  • Protriptyline hydrochloride (USP)
  • REGID_for_CID_6603149
  • 5H-Dibenzo[a, N-methyl-, hydrochloride
  • Protriptyline (hydrochloride) (Standard)
  • Protriptyline hydrochloride, >=99% (TLC), powder
  • Protriptyline.HCl, 1mg/ml in Methanol (as free base)
  • 5-[3-(Methylamino)propyl]-5H-dibenzo[a,d]cycloheptene hydrochloride
Show all 27 synonyms
  • 5H-Dibenzo(a,d)cycloheptene-5-propylamine, N-methyl-, hydrochloride
  • Protriptyline Hydrochloride 1.0 mg/ml in Methanol (as free base)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
299.85 g/molcalc.
Exact mass
299.1441 Dacalc.
LogP (octanol/water)
4.72calc.
Topological polar surface area
12.03 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
1calc.
Rotatable bonds
4calc.
Heavy atoms
21calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.26calc.
Formal charge
0calc.
Stereocentres
0calc.
Components
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1=Cc2ccccc2Cc2ccccc21

C1=Cc2ccccc2Cc2ccccc21

3 rings, 15 atoms, the 5H-Dibenzo(a,d)cycloheptene ring system.

55 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H301Toxic if swallowed.
  • H312Harmful in contact with skin.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H332Harmful if inhaled.
  • H335May cause respiratory irritation.
Precautionary statements (20)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P317Get medical help.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Protriptyline hydrochloride suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 28 suppliers
28 of 28 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

28 suppliers in 10 countries

Send one request to many suppliers

Choose up to 10 suppliers or let us match your request. Compare quotes side by side, free.

Choose suppliersPost a request

Protriptyline hydrochloride price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

Get latest price

Uses and applications

What the substance is used for, by industry and function

Roles

  • antidepressant
  • central nervous system drug
  • pharmaceutical
  • psychotropic drug

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Protriptyline hydrochloride is traded under.

HS 2921.49Indicative HS code

Aromatic monoamines and their derivatives, salts thereof, other

World exports in 2024
$1.14B
+5.6% vs 2023, imports $1.06B
2019 to 2024
Top exporters
  1. Germany23.3%
  2. China19.4%
  3. Singapore14.6%
Top importers
  1. Belgium15.9%
  2. South Korea15.0%
  3. Germany12.8%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Protriptyline hydrochloride is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Protriptyline hydrochloride, based on the data on this page

What is Protriptyline hydrochloride?

Protriptyline Hydrochloride is the hydrochloride salt form of protriptyline, a tricyclic secondary amine with antidepressant property. Protriptyline hydrochloride blocks the re-uptake of norepinephrine and serotonin by nerve terminals, thereby increasing available norepinephrine and serotonin.

What is the CAS number of Protriptyline hydrochloride?

The CAS registry number of Protriptyline hydrochloride is 1225-55-4.

What is the molecular formula and weight of Protriptyline hydrochloride?

The molecular formula of Protriptyline hydrochloride is C19H22ClN and its molar mass is 299.85 g/mol.

What is Protriptyline hydrochloride used for?

Known uses and roles of Protriptyline hydrochloride include antidepressant, central nervous system drug, pharmaceutical and psychotropic drug.

Is Protriptyline hydrochloride hazardous?

Protriptyline hydrochloride carries the GHS signal word "Danger". Main hazards: toxic if swallowed, harmful in contact with skin, causes skin irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Protriptyline hydrochloride?

Protriptyline hydrochloride is usually classified under HS code 292149 (Aromatic monoamines and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Protriptyline hydrochloride?

CompoundList lists 28 suppliers of Protriptyline hydrochloride in China, United States, India, Italy and 6 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Protriptyline hydrochloride in India?

2 suppliers in India list Protriptyline hydrochloride on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Protriptyline hydrochloride?

Suppliers quote Protriptyline hydrochloride on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Protriptyline hydrochloride

Get quotes for Protriptyline hydrochloride

Post one free request with your grade, quantity and destination. Matching suppliers send quotes you can compare side by side.
Post a request Sell Protriptyline hydrochloride
Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
Embed this structure on your websiteShow code

Paste this code into your page to show the 2D structure of Protriptyline hydrochloride with a 3D view, its CAS number where known and a link back to this page. Free to use with the link kept.

<iframe src="https://www.compoundlist.com/embed/structure/protriptyline-hydrochloride-1225-55-4" title="Protriptyline hydrochloride structure on CompoundList" width="360" height="420" style="border:1px solid #E7E2DA;border-radius:12px;max-width:100%" loading="lazy" referrerpolicy="strict-origin-when-cross-origin"></iframe>
Preview the embed

Explore more in Pharmaceuticals and APIs or HS code 292149

28 suppliers
Free quotes, contact stays private
Get quotes