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Cardiovascular and metabolic drugs

Quinethazone

Also known as Hydromox, Quinethazon, Quinethazonum

CAS 73-49-4Formula C10H12ClN3O3SMolar mass 289.74 g/molEC 200-801-7
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Quinethazone chemical structure, C10H12ClN3O3S, CAS 73-49-4
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Fibrous crystals from 50% acetone
Melting point
250 to 252 °C
Solubility
Sol in acetone, alcohol.
HS code
293590
Category
Cardiovascular and metabolic drugs
Illustrative photo, closed jumbo bulk bags in a warehouse in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Quinethazone?

Plain description, key identifiers and synonyms

Quinethazone is a member of the class of quinazolines that is quinazolin-4-one substituted at positions 2, 6 and 7 by ethyl, sulfamoyl and chloro groups respectively, a thiazide-like diuretic used to treat hypertension. It has a role as a diuretic and an antihypertensive agent.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
7-chloro-2-ethyl-4-oxo-2,3-dihydro-1H-quinazoline-6-sulfonamide
CAS number
73-49-4 CAS number cross-checked
EC number
200-801-7
Molecular formula
C10H12ClN3O3S
UNII
455E0S048W
MDL number
MFCD00867329
InChIKey
AGMMTXLNIQSRCG-UHFFFAOYSA-N
InChI
InChI=1S/C10H12ClN3O3S/c1-2-9-13-7-4-6(11)8(18(12,16)17)3-5(7)10(15)14-9/h3-4,9,13H,2H2,1H3,(H,14,15)(H2,12,16,17)
SMILES (canonical and isomeric)
CCC1NC2=CC(=C(C=C2C(=O)N1)S(=O)(=O)N)Cl

Synonyms

  • Hydromox
  • Quinethazon
  • Quinethazonum
  • Aquamox
  • Idrokin
  • Quinetazona
  • 7-chloro-2-ethyl-4-oxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide
  • CL 36010
  • 7-Chloro-2-ethyl-1,2,3,4-tetrahydro-4-oxo-6-quinazolinesulfonamide
  • 7-Chloro-2-ethyl-1,2,3,4-tetrahydro-4-oxo-6-sulfamoylquinazoline
  • 7-Chloro-2-ethyl-6-sulfamoyl-1,2,3,4-tetrahydro-4-quinazolinone
  • 6-Quinazolinesulfonamide, 7-chloro-2-ethyl-1,2,3,4-tetrahydro-4-oxo-
  • 7-chloro-2-ethyl-4-hydroxy-1,2-dihydroquinazoline-6-sulfonamide
  • quinetazone
  • Chinethazonum
  • Chinetazone
  • 7-chloro-2-ethyl-4-oxo-2,3-dihydro-1H-quinazoline-6-sulfonamide
  • Hydromox (TN)
  • Quinethazone (JAN/INN)
  • Quinethazone (1.5 g)
  • 2-Ethyl-7-chloro-1,2,3,4-tetrahydro-4-oxochinazolin-6-sulfonamid
  • 2-Ethyl-7-chloro-1,2,3,4-tetrahydro-4-oxoquinazoline-6-sulfonamide
  • 5-25-09-00214 (Beilstein Handbook Reference)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Fibrous crystals from 50% acetoneexp.
Odour
ODORLESSexp.
Taste
BITTER TASTEexp.
Melting point
250 to 252 °Cexp.
Solubility
Sol in acetone, alcohol.exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
289.74 g/molcalc.
Exact mass
289.0288 Dacalc.
LogP (octanol/water)
0.88calc.
Topological polar surface area
101.3 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
2calc.
Heavy atoms
18calc.
Rings
2calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.3calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1NCNc2ccccc21

O=C1NCNc2ccccc21

2 rings, 11 atoms, the 2,3-Dihydroquinazolin-4(1H)-one ring system.

41 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Quinethazone suppliers

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Quinethazone price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Therapeutic category: Diuretic, Antihypertensive.

An orally effective benzothiadiazine diuretic and antihypertensive drug.

Use classes: Pharmaceuticals.

Industries and functions

Pharmacological actions

  • Sodium Chloride Symporter Inhibitors

Roles

  • antihypertensive agent
  • cardiovascular drug
  • diuretic
  • pharmaceutical

Pharmacology

Quinethazone is a long-acting, quinazolinesulfonamide derivative with thiazide-like diuretic activity. Quinethazone acts in a similar manner to that of other typical thiazide diuretics and is no longer commercially available in the United States.

How it is made

Cohen et al, J Am Chem Soc 82, 2731 (1960), Cohen, Vaughan, Jr, US patent 2,976,289 (1961 to Am Cyanamid).

4'-Chloro-o-acetotoluidide is subjected to chlorosulfonation & subsequent amination to form 2-amino-4-chloro-5-sulfamoylbenzamide. Refluxing with an acidulated alcoholic solution of the diethylacetal of propionaldehyde effects the required condensation cyclization to yield quinethazone.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Quinethazone is traded under.

HS 2935.90Indicative HS code

Sulphonamides, other

World exports in 2024
$5.64B
−11.0% vs 2023, imports $8.56B
2019 to 2024
Top exporters
  1. Ireland43.1%
  2. China12.0%
  3. India * partner reported9.5%
Top importers
  1. United States23.6%
  2. Slovenia19.1%
  3. Spain11.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Quinethazone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Quinethazone, based on the data on this page

What is Quinethazone?

Quinethazone is a member of the class of quinazolines that is quinazolin-4-one substituted at positions 2, 6 and 7 by ethyl, sulfamoyl and chloro groups respectively, a thiazide-like diuretic used to treat hypertension. It has a role as a diuretic and an antihypertensive agent.

What is the CAS number of Quinethazone?

The CAS registry number of Quinethazone is 73-49-4.

What is the molecular formula and weight of Quinethazone?

The molecular formula of Quinethazone is C10H12ClN3O3S and its molar mass is 289.74 g/mol.

What is Quinethazone used for?

Therapeutic category: Diuretic, Antihypertensive. An orally effective benzothiadiazine diuretic and antihypertensive drug. Use classes: Pharmaceuticals.

Is Quinethazone hazardous?

No GHS hazard classification for Quinethazone is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Quinethazone?

Quinethazone is usually classified under HS code 293590 (Sulphonamides, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Quinethazone?

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What is the price of Quinethazone?

Suppliers quote Quinethazone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Quinethazone

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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