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Screening compounds

Rabusertib

Also known as N-(5-bromo-4-methyl-2-{[(2S)-morpholin-2-yl]methoxy}phenyl)-N'-(5-methylpyrazin-2-yl)urea, 3-(5-bromo-4-methyl-2-(((2S)-morpholin-2-yl)methoxy)phenyl)-1-(5-methylpyrazin-2-yl)urea, 3-(5-bromo-4-methyl-2-{[(2S)-morpholin-2-yl]methoxy}phenyl)-1-(5-methylpyrazin-2-yl)urea

CAS 911222-45-2Formula C18H22BrN5O3Molar mass 436.31 g/mol
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Rabusertib chemical structure, C18H22BrN5O3, CAS 911222-45-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
911222-45-2
Formula
C18H22BrN5O3
Molar mass
436.31 g/mol
HS code
293499
Category
Screening compounds

What is Rabusertib?

Plain description, key identifiers and synonyms

1-[5-bromo-4-methyl-2-[[(2S)-2-morpholinyl]methoxy]phenyl]-3-(5-methyl-2-pyrazinyl)urea is a member of ureas.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1-[5-bromo-4-methyl-2-[[(2S)-morpholin-2-yl]methoxy]phenyl]-3-(5-methylpyrazin-2-yl)urea
CAS number
911222-45-2 CAS number cross-checked
Molecular formula
C18H22BrN5O3
UNII
3S9L1NU6U7
MDL number
MFCD18633253
InChIKey
SYYBDNPGDKKJDU-ZDUSSCGKSA-N
InChI
InChI=1S/C18H22BrN5O3/c1-11-5-16(27-10-13-8-20-3-4-26-13)15(6-14(11)19)23-18(25)24-17-9-21-12(2)7-22-17/h5-7,9,13,20H,3-4,8,10H2,1-2H3,(H2,22,23,24,25)/t13-/m0/s1
Canonical SMILES
Cc1cnc(NC(=O)Nc2cc(Br)c(C)cc2OCC2CNCCO2)cn1
Isomeric SMILES
CC1=CC(=C(C=C1Br)NC(=O)NC2=NC=C(N=C2)C)OC[C@@H]3CNCCO3

Synonyms

  • N-(5-bromo-4-methyl-2-{[(2S)-morpholin-2-yl]methoxy}phenyl)-N'-(5-methylpyrazin-2-yl)urea
  • 3-(5-bromo-4-methyl-2-(((2S)-morpholin-2-yl)methoxy)phenyl)-1-(5-methylpyrazin-2-yl)urea
  • 3-(5-bromo-4-methyl-2-{[(2S)-morpholin-2-yl]methoxy}phenyl)-1-(5-methylpyrazin-2-yl)urea
  • N-(5-bromo-4-methyl-2-(((2S)-morpholin-2-yl)methoxy)phenyl)-N'-(5-methylpyrazin-2-yl)urea
  • Urea, N-(5-bromo-4-methyl-2-((2S)-2-morpholinylmethoxy)phenyl)-N'-(5-methyl-2-pyrazinyl)-
  • Urea, N-[5-bromo-4-methyl-2-[(2S)-2-morpholinylmethoxy]phenyl]-N'-(5-methyl-2-pyrazinyl)-
  • Checkpoint Kinase 2 Inhibitor LY2603618
  • 1-(5-bromo-4-methyl-2-S-(morpholin-2-yl-methoxy)-phenyl)-3-(5-methyl-pyrazin-2-yl)-urea
  • LY 2603618
  • Rabusertib (LY2603618)
  • (S)-1-(5-bromo-4-methyl-2-(morpholin-2-ylmethoxy)phenyl)-3-(5-methylpyrazin-2-yl)urea
  • 1-[5-bromo-4-methyl-2-[[(2S)-morpholin-2-yl]methoxy]phenyl]-3-(5-methylpyrazin-2-yl)urea
  • Urea, N-(5-bromo-4-methyl-2-((2S)-2-morpholinylmethoxy)phenyl)-N'-(5-methyl-2- pyrazinyl)-
  • ly2603618 IC-83
  • LY2603618, IC-83
  • LY2603618(IC-83)
  • C18H22BrN5O3
  • Sdccgsbi-0654427.p001
  • (S)-1-(5-bromo-4-methyl-2-(morpholin-2-ylmethoxy)phenyl)-3-(5-methylpyrazin-2-yl)urea.
  • LY2603618(IC-83)?
  • 2-(3,4-dihydroxyphenyl)-8-beta-D-glucopyranosy
  • N-[5-bromo-4-methyl-2-[(2S)-2-morpholinylmethoxy]phenyl]-N'-(5-methyl-2-pyrazinyl)urea
  • 1-(5-Bromo-4-methyl-2-((2S)-morpholin-2-ylmethoxy)phenyl)-3-(5-methylpyrazin-2-yl)urea

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
436.31 g/molcalc.
Exact mass
435.0906 Dacalc.
LogP (octanol/water)
2.87calc.
Topological polar surface area
97.4 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
5calc.
Heavy atoms
27calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.39calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(Nc1cnccn1)Nc1ccccc1OCC1CNCCO1

O=C(Nc1cnccn1)Nc1ccccc1OCC1CNCCO1

3 rings, 24 atoms.

No other chemical in our database has this scaffold.

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Rabusertib suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 4 suppliers
4 of 4 offers

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Where suppliers are based

4 suppliers in 2 countries

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Rabusertib price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antineoplastic agent
  • pharmaceutical

Pharmacology

Rabusertib is an inhibitor of the cell cycle checkpoint kinase 2 (chk2) with potential chemopotentiating activity. Rabusertib binds to and inhibits the activity of chk2, which may prevent the repair of DNA caused by DNA-damaging agents, thus potentiating the antitumor efficacies of various chemotherapeutic agents. Chk2, an ATP-dependent serine-threonine kinase, is a key component in the DNA replication-monitoring checkpoint system and is activated by double-stranded breaks (DSBs), activated chk2 is overexpressed by a variety of cancer cell types.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Rabusertib is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Rabusertib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Rabusertib, based on the data on this page

What is Rabusertib?

1-[5-bromo-4-methyl-2-[[(2S)-2-morpholinyl]methoxy]phenyl]-3-(5-methyl-2-pyrazinyl)urea is a member of ureas.

What is the CAS number of Rabusertib?

The CAS registry number of Rabusertib is 911222-45-2.

What is the molecular formula and weight of Rabusertib?

The molecular formula of Rabusertib is C18H22BrN5O3 and its molar mass is 436.31 g/mol.

What is Rabusertib used for?

Known uses and roles of Rabusertib include building blocks in research and laboratory, screening compounds in research and laboratory, antineoplastic agent and pharmaceutical.

Is Rabusertib hazardous?

No GHS hazard classification for Rabusertib is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Rabusertib?

Rabusertib is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Rabusertib?

CompoundList lists 4 suppliers of Rabusertib in China and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Rabusertib?

Suppliers quote Rabusertib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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