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Cardiovascular and metabolic drugs

Ranolazine

Also known as Ranexa, RAN D, Ran4

CAS 95635-55-5Formula C24H33N3O4Molar mass 427.55 g/molEC 620-450-7
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant, Serious health hazard 155 suppliers listed Drug substance
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Ranolazine chemical structure, C24H33N3O4, CAS 95635-55-5
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
95635-55-5
Formula
C24H33N3O4
Appearance
White to off-white solid
Solubility
Soluble in dichloromethane, methanol, sparingly soluble in tetrahydrofuran, ethanol, ace…
HS code
293359
Category
Cardiovascular and metabolic drugs
Illustrative photo, a white jumbo bulk bag of powder in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Ranolazine?

Plain description, key identifiers and synonyms

N-(2,6-dimethylphenyl)-2-{4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl}acetamide is an aromatic amide obtained by formal condensation of the carboxy group of 2-{4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl}acetic acid with the amino group of 2,6-dimethylaniline. It is a monomethoxybenzene, a monocarboxylic acid amide, a secondary alcohol, a N-alkylpiperazine and an aromatic amide.

Ranolazine is a drug to treat angina that was first approved in 2006.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-(2,6-dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]acetamide
CAS number
95635-55-5 CAS number cross-checkedOther or deprecated CAS: 1080496-58-7, 142387-99-3, 95635-56-6
EC number
620-450-7
Molecular formula
C24H33N3O4
UNII
A6IEZ5M406
MDL number
MFCD00864690
InChIKey
XKLMZUWKNUAPSZ-UHFFFAOYSA-N
InChI
InChI=1S/C24H33N3O4/c1-18-7-6-8-19(2)24(18)25-23(29)16-27-13-11-26(12-14-27)15-20(28)17-31-22-10-5-4-9-21(22)30-3/h4-10,20,28H,11-17H2,1-3H3,(H,25,29)
SMILES (canonical and isomeric)
CC1=C(C(=CC=C1)C)NC(=O)CN2CCN(CC2)CC(COC3=CC=CC=C3OC)O

Synonyms

  • Ranexa
  • RAN D
  • Ran4
  • renolazine
  • (+-)-Ranolazine
  • Aspruzyo
  • Ranolazina
  • N-(2,6-Dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazineacetamide
  • N-(2,6-dimethylphenyl)-4-(2-hydroxy-3-(2-methoxyphenoxy)propyl)-1-piperazineacetamide
  • 1-Piperazineacetamide, N-(2,6-dimethylphenyl)-4-(2-hydroxy-3-(2-methoxyphenoxy)propyl)-
  • 1-Piperazineacetamide, N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-
  • ranolazinum
  • HCl, Ranolazine
  • N-(2,6-dimethylphenyl)-2-(4-(2-hydroxy-3-(2-methoxyphenoxy)propyl)piperazin-1-yl)ethanimidic acid
  • N-(2,6-dimethylphenyl)-2-{4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl}ethanimidic acid
  • Aspruzyo sprinkle
  • Hydrochloride, Ranolazine
  • Dihydrochloride, Ranolazine
  • 43285, RS
  • RS 43285193
  • RS 43285 193
  • N-(2,6-dimethylphenyl)-2-(4-(2-hydroxy-3-(2-methoxyphenoxy)propyl)piperazin-1-yl)acetamide
  • N-(2,6-dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]acetamide
  • Latixa
  • N-(2,6-dimethylphenyl)-2-{4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl}acetamide
Show all 34 synonyms
  • Ranolazine (usp-rs)
  • (-)-Ranolazine
  • Ranexa (TN)
  • Ranolazine (USAN/INN)
  • Ranolazin
  • Ranolaz
  • (+/-)-Ranolazine
  • Ranolazine (Ranexa)?
  • Ranolazine (Standard)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
White to off-white solidexp.
Solubility
Soluble in dichloromethane, methanol, sparingly soluble in tetrahydrofuran, ethanol, acetonitrile, acetone, slightly soluble in ethyl acetate, isopropanol, toluene, ethyl ether, very slightly soluble in waterexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
427.55 g/molcalc.
Exact mass
427.2471 Dacalc.
LogP (octanol/water)
2.31calc.
Topological polar surface area
74.27 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
9calc.
Heavy atoms
31calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.46calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(CN1CCN(CCCOc2ccccc2)CC1)Nc1ccccc1

O=C(CN1CCN(CCCOc2ccccc2)CC1)Nc1ccccc1

3 rings, 26 atoms.

21 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H301Toxic if swallowed.
  • H302Harmful if swallowed.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
  • H336May cause drowsiness or dizziness.
  • H361Suspected of damaging fertility or the unborn child.
  • H373May cause damage to organs through prolonged or repeated exposure.
Precautionary statements (23)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Ranolazine suppliers

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All 155 suppliers
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Where suppliers are based

155 suppliers in 21 countries

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Ranolazine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Cardiovascular Agents
  • Sodium Channel Blockers

Roles

  • anti-arrhythmia drug
  • antihypertensive agent
  • antispasmodic drug
  • biophysical role
  • cardiovascular drug
  • hypoglycemic agent
  • membrane transport modulator
  • muscle relaxant
  • neuromuscular agent
  • pharmaceutical
  • protective agent
  • renoprotective agent
  • sodium channel blocker
  • sodium channel modulator

Pharmacology

Ranolazine is an Anti-anginal. The mechanism of action of ranolazine is as a Cytochrome P450 3A Inhibitor, and P-Glycoprotein Inhibitor, and Cytochrome P450 2D6 Inhibitor, and Organic Cation Transporter 2 Inhibitor.

How it is made

Preparation: A. F. Kluge et al., EP 126449, eidem, US 4567264 (1984, 1986 both to Syntex)

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Ranolazine is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Ranolazine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Ranolazine, based on the data on this page

What is Ranolazine?

N-(2,6-dimethylphenyl)-2-{4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl}acetamide is an aromatic amide obtained by formal condensation of the carboxy group of 2-{4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl}acetic acid with the amino group of 2,6-dimethylaniline.

What is the CAS number of Ranolazine?

The CAS registry number of Ranolazine is 95635-55-5. Other or deprecated CAS numbers: 1080496-58-7, 142387-99-3, 95635-56-6.

What is the molecular formula and weight of Ranolazine?

The molecular formula of Ranolazine is C24H33N3O4 and its molar mass is 427.55 g/mol.

What is Ranolazine used for?

Known uses and roles of Ranolazine include cardiovascular drugs in pharmaceuticals, anti-arrhythmia drug, antihypertensive agent, antispasmodic drug, biophysical role and 12 more.

Is Ranolazine hazardous?

Ranolazine carries the GHS signal word "Danger". Main hazards: toxic if swallowed, harmful if swallowed, causes skin irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Ranolazine?

Ranolazine is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Ranolazine?

CompoundList lists 155 suppliers of Ranolazine in India, United States, China, Germany and 17 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Ranolazine in India?

41 suppliers in India list Ranolazine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Ranolazine?

Suppliers quote Ranolazine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Ranolazine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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