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Aliphatic and alicyclic building blocks

RefChem:920783

Also known as e-64c, E 64c, Loxistatin acid

CAS 76684-89-4Formula C15H26N2O5Molar mass 314.38 g/mol
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RefChem:920783 chemical structure, C15H26N2O5, CAS 76684-89-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
76684-89-4
Formula
C15H26N2O5
Molar mass
314.38 g/mol
HS code
292429
Category
Aliphatic and alicyclic building blocks

What is RefChem:920783?

Plain description, key identifiers and synonyms

E-64c is a leucine derivative.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2S,3S)-3-[[(2S)-4-methyl-1-(3-methylbutylamino)-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylic acid
CAS number
76684-89-4
Molecular formula
C15H26N2O5
UNII
28DN73YPX4
MDL number
MFCD00132882
InChIKey
SCMSYZJDIQPSDI-SRVKXCTJSA-N
InChI
InChI=1S/C15H26N2O5/c1-8(2)5-6-16-13(18)10(7-9(3)4)17-14(19)11-12(22-11)15(20)21/h8-12H,5-7H2,1-4H3,(H,16,18)(H,17,19)(H,20,21)/t10-,11-,12-/m0/s1
Canonical SMILES
CC(C)CCNC(=O)C(CC(C)C)NC(=O)C1OC1C(=O)O
Isomeric SMILES
CC(C)CCNC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1[C@H](O1)C(=O)O

Synonyms

  • e-64c
  • E 64c
  • Loxistatin acid
  • N-(N-(3-carboxyoxirane-2-carbonyl)leucyl)isoamylamine
  • E-64-c
  • (2S,3S)-3-[[(2S)-4-methyl-1-(3-methylbutylamino)-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylic acid
  • L-trans-Epoxysuccinyl-Leu-3-methylbutylamide
  • (2S,3S)-3-(((S)-1-(Isopentylamino)-4-methyl-1-oxopentan-2-yl)carbamoyl)oxirane-2-carboxylic acid
  • HO-tES-Leu-NH-CH2-CH2CH(CH3)2
  • (2S,3S)-trans-Epoxysuccinyl-L-leucylamido-3-methylbutane
  • EP 475 (Enzyme inhibitor)
  • Loxistatinacid
  • loxistatin-acid
  • E-64c, EP 475
  • (2S,3S)-3-{[(1S)-3-methyl-1-[(3-methylbutyl)carbamoyl]butyl]carbamoyl}oxirane-2-carboxylic acid
  • E-64c, Calpain Inhibitor
  • (Carboxymethyl)trimethylammon
  • [2S,3S]-trans-Epoxysuccinyl-L-leucylamido-3-methylbutane
  • (+)-(2S,3S)-3-((S)-3-Methyl-1-(3-methylbutylcarbamoyl)butylcarbamoyl)-2-oxiranecarboxylic acid
  • epoxysuccinyl derivative E64c
  • E-64c?
  • Oxiranecarboxylic acid, 3-(((3-methyl-1-(((3-methylbutyl)amino)carbonyl)butyl)amino)carbonyl)-, (2S-(2-alpha,3-beta(R*)))-
  • Oxiranecarboxylic acid, 3-(((3-methyl-1-(((3-methylbutyl)amino)carbonyl)butyl)amino)carbonyl)-, (2S-(2alpha,3beta(R*)))-
  • (2S,3S)-3-[[(1S)-1-(isoamylcarbamoyl)-3-methyl-butyl]carbamoyl]oxirane-2-carboxylic acid
  • (2S,3S)-3-[[(1S)-1-(isopentylcarbamoyl)-3-methyl-butyl]carbamoyl]oxirane-2-carboxylic acid
Show all 29 synonyms
  • (2S,3S)-3-[[(2S)-4-methyl-1-(3-methylbutylamino)-1-oxidanylidene-pentan-2-yl]carbamoyl]oxirane-2-carboxylic acid
  • (2S,3S)-3-[[[(1S)-3-Methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-2-oxiranecarboxylic acid
  • (2S,3S)-3-[[[(2S)-4-methyl-1-(3-methylbutylamino)-1-oxopentan-2-yl]amino]-oxomethyl]-2-oxiranecarboxylic acid
  • 2-Oxiranecarboxylic acid, 3-[[[(1S)-3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-, (2S,3S)-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
314.38 g/molcalc.
Exact mass
314.1842 Dacalc.
LogP (octanol/water)
0.53calc.
Topological polar surface area
108 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
9calc.
Heavy atoms
22calc.
Rings
1calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.8calc.
Formal charge
0calc.
Stereocentres
3calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1CO1

C1CO1

1 ring, 3 atoms, the Ethylene oxide ring system.

3,057 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

RefChem:920783 suppliers

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RefChem:920783 price

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Uses and applications

What the substance is used for, by industry and function

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code RefChem:920783 is traded under.

HS 2924.29Indicative HS code

Cyclic amides (including cyclic carbamates) and their derivatives, salts thereof, other

World exports in 2024
$5.69B
−5.1% vs 2023, imports $5.8B
2019 to 2024
Top exporters
  1. China32.3%
  2. Switzerland * partner reported13.6%
  3. Norway * partner reported12.8%
Top importers
  1. United States15.9%
  2. Ireland15.8%
  3. Germany11.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for RefChem:920783 is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about RefChem:920783, based on the data on this page

What is RefChem:920783?

E-64c is a leucine derivative.

What is the CAS number of RefChem:920783?

The CAS registry number of RefChem:920783 is 76684-89-4.

What is the molecular formula and weight of RefChem:920783?

The molecular formula of RefChem:920783 is C15H26N2O5 and its molar mass is 314.38 g/mol.

What is RefChem:920783 used for?

Known uses and roles of RefChem:920783 include building blocks in research and laboratory.

Is RefChem:920783 hazardous?

No GHS hazard classification for RefChem:920783 is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of RefChem:920783?

RefChem:920783 is usually classified under HS code 292429 (Cyclic amides (including cyclic carbamates) and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy RefChem:920783?

CompoundList lists 1 supplier of RefChem:920783 in Japan. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of RefChem:920783?

Suppliers quote RefChem:920783 on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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