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Central nervous system drugs

Reserpine

Also known as Serpalan, Serpasil, Apoplon

CAS 50-55-5Formula C33H40N2O9Molar mass 608.69 g/molEC 200-047-9
GHS signal word: Warning. Pictograms: Harmful or irritant 91 suppliers listed Drug substance
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Reserpine chemical structure, C33H40N2O9, CAS 50-55-5
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
White or pale buff to slightly yellowish powder
Melting point
264.5 °C
Solubility
In water, 73 mg/l @ 30 °C
HS code
293979
Category
Central nervous system drugs
UN number
UN 3077
Illustrative photo, fine white powder in a white HDPE jar on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Reserpine?

Plain description, key identifiers and synonyms

Reserpine is an alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. It has a role as an adrenergic uptake inhibitor, an antihypertensive agent, a xenobiotic, a first generation antipsychotic, an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor, a plant metabolite and an environmental contaminant. It is a methyl ester, a yohimban alkaloid and an alkaloid ester. It is functionally related to a reserpic acid.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
methyl (1R,15S,17R,18R,19S,20S)-6,18-dimethoxy-17-(3,4,5-trimethoxybenzoyl)oxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate
CAS number
50-55-5 CAS number cross-checked
EC number
200-047-9
Molecular formula
C33H40N2O9
UNII
8B1QWR724A
MDL number
MFCD00005091
InChIKey
QEVHRUUCFGRFIF-MDEJGZGSSA-N
InChI
InChI=1S/C33H40N2O9/c1-38-19-7-8-20-21-9-10-35-16-18-13-27(44-32(36)17-11-25(39-2)30(41-4)26(12-17)40-3)31(42-5)28(33(37)43-6)22(18)15-24(35)29(21)34-23(20)14-19/h7-8,11-12,14,18,22,24,27-28,31,34H,9-10,13,15-16H2,1-6H3/t18-,22+,24-,27-,28+,31+/m1/s1
Canonical SMILES
COC(=O)C1C2CC3c4[nH]c5cc(OC)ccc5c4CCN3CC2CC(OC(=O)c2cc(OC)c(OC)c(OC)c2)C1OC
Isomeric SMILES
CO[C@H]1[C@@H](C[C@@H]2CN3CCC4=C([C@H]3C[C@@H]2[C@@H]1C(=O)OC)NC5=C4C=CC(=C5)OC)OC(=O)C6=CC(=C(C(=C6)OC)OC)OC

Synonyms

  • Serpalan
  • Serpasil
  • Apoplon
  • Sandril
  • Serpivite
  • Alserin
  • Rau-Sed
  • (-)-Reserpine
  • Deserpine
  • Elserpine
  • Eskaserp
  • Hiserpia
  • Raunervil
  • Raupasil
  • Rausedil
  • Rausedyl
  • Rausingle
  • Rauwasedin
  • Reserpin
  • Reserpina
  • Reserpoid
  • Roxinoid
  • Serpanray
  • Benazyl
  • Resine
Show all 39 synonyms
  • Rivasin
  • Serpate
  • Austrapine
  • Bioserpine
  • Carditivo
  • Carpacil
  • Carrserp
  • Enipresser
  • Escaspere
  • Eserpine
  • Helfoserpin
  • Hiposerpil
  • Interpina
  • Lemiserp

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
White or pale buff to slightly yellowish powderexp.
Odour
Odorlessexp.
Melting point
264.5 °Cexp.
Solubility
In water, 73 mg/l @ 30 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
608.69 g/molcalc.
Exact mass
608.2734 Dacalc.
LogP (octanol/water)
4.17calc.
Topological polar surface area
117.8 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
10calc.
Rotatable bonds
8calc.
Heavy atoms
44calc.
Rings
6calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.52calc.
Formal charge
0calc.
Stereocentres
6calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(OC1CCC2CC3c4[nH]c5ccccc5c4CCN3CC2C1)c1ccccc1

O=C(OC1CCC2CC3c4[nH]c5ccccc5c4CCN3CC2C1)c1ccccc1

6 rings, 30 atoms.

52 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
Precautionary statements (5)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P317If swallowed: Get medical help.
  • P330Rinse mouth.
  • P501Dispose of contents and container in accordance with local regulations.
UN number
UN 3077

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Reserpine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 91 suppliers
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Where suppliers are based

91 suppliers in 14 countries

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Reserpine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Antihypertensive, central depressant, and sedative drug for both humans and animals.

Therapeutic category: Antihypertensive.

Therapeutic category (veterinary): Hypotensive, tranquilizer. Has been used to prevent aortic rupture in turkeys.

Use classes: Pharmaceuticals.

Pharmacological actions

  • Adrenergic Uptake Inhibitors
  • Antihypertensive Agents
  • Antipsychotic Agents

Roles

  • adrenergic agent
  • adrenergic uptake inhibitor
  • antiatherosclerotic agent
  • antihypertensive agent
  • antipsychotic agent
  • cardiovascular drug
  • central nervous system depressant
  • central nervous system drug
  • environmental contaminant
  • enzyme inhibitor
  • eukaryotic metabolite
  • first generation antipsychotic
  • hypoglycemic agent
  • metabolite
  • neurotransmitter agent
  • pharmaceutical
  • plant metabolite
  • psychotropic drug
  • tranquilizing drug
  • xenobiotic

Pharmacology

Reserpine is a Catecholamine-depleting Sympatholytic. The physiologic effect of reserpine is by means of Decreased Sympathetic Activity.

How it is made

Isolation from roots of Rauwolfia serpentina L Benth, Apocynaceae: Dorfman et al, Helv Chim Acta 37, 59 (1954), Schwyzer, Mueller, US patent 2,833,771 (1958 to Ciba). Structure: Dorfman et al, Loc cit, Neuss et al, J Am Chem Soc 76, 2463 (1954). ... synthesis: Woodward et al, J Am Chem Soc 78, 2023 (1956).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

United States

  • TSCA inventory (USA)
    Status: Active in US commerce, Regulatory flags: Significant new use rule

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Reserpine is traded under.

HS 2939.79Indicative HS code

Alkaloids of vegetal origin, other than cocaine, ecgonine, salts, esters and other derivatives, not elsewhere…

World exports in 2024
$701M
+18.9% vs 2023, imports $830M
2019 to 2024
Top exporters
  1. Switzerland * partner reported25.3%
  2. Germany21.4%
  3. India * partner reported14.9%
Top importers
  1. United States20.9%
  2. Germany14.7%
  3. Italy14.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Reserpine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Reserpine, based on the data on this page

What is Reserpine?

Reserpine is an alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. It has a role as an adrenergic uptake inhibitor, an antihypertensive agent, a xenobiotic, a first generation antipsychotic, an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor, a plant metabolite and an environmental contaminant.

What is the CAS number of Reserpine?

The CAS registry number of Reserpine is 50-55-5.

What is the molecular formula and weight of Reserpine?

The molecular formula of Reserpine is C33H40N2O9 and its molar mass is 608.69 g/mol.

What is Reserpine used for?

Antihypertensive, central depressant, and sedative drug for both humans and animals. Therapeutic category: Antihypertensive. Therapeutic category (veterinary): Hypotensive, tranquilizer. Has been used to prevent aortic rupture in turkeys. Use classes: Pharmaceuticals.

Is Reserpine hazardous?

Reserpine carries the GHS signal word "Warning". Main hazards: harmful if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Reserpine?

Reserpine is usually classified under HS code 293979 (Alkaloids, natural or reproduced by synthesis, and their salts, ethers, esters and other…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Reserpine?

CompoundList lists 91 suppliers of Reserpine in United States, China, Germany, India and 10 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Reserpine in India?

6 suppliers in India list Reserpine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Reserpine?

Suppliers quote Reserpine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Reserpine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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