CompoundList
Sign in
Pharmaceuticals and APIs

Ribociclib succinate

Also known as LEE-011 succinate, Birociclib, Kisqali femara co-pack component ribociclib succinate

CAS 1374639-75-4Formula C27H36N8O5Molar mass 552.64 g/molEC 801-486-4
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant, Serious health hazard, Hazardous to the environment 64 suppliers listed Drug substance
Get quotes Compare 64 suppliers
Ribociclib succinate chemical structure, C27H36N8O5, CAS 1374639-75-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
1374639-75-4
Formula
C27H36N8O5
Molar mass
552.64 g/mol
EC number
801-486-4
HS code
293359
Category
Pharmaceuticals and APIs

What is Ribociclib succinate?

Plain description, key identifiers and synonyms

Ribociclib Succinate is the succinate salt form of ribociclib, an orally available inhibitor of the cyclin-dependent kinases (CDKs) 4 and 6, with antineoplastic activity. Upon oral administration, ribociclib specifically targets, binds to and inhibits CDK4 and CDK6. This inhibits the cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, which inhibits phosphorylation of the retinoblastoma (Rb) protein. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of CDK4/6, as seen in certain types of cancer, causes cell cycle dysregulation.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
butanedioic acid, 7-cyclopentyl-N,N-dimethyl-2-[(5-piperazin-1-yl-2-pyridinyl)amino]pyrrolo[2,3-d]pyrimidine-6-carboxamide
CAS number
1374639-75-4 CAS number cross-checked
EC number
801-486-4
Molecular formula
C27H36N8O5
UNII
BG7HLX2919
MDL number
MFCD28167746
InChIKey
NHANOMFABJQAAH-UHFFFAOYSA-N
InChI
InChI=1S/C23H30N8O.C4H6O4/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30;5-3(6)1-2-4(7)8/h7-8,13-15,17,24H,3-6,9-12H2,1-2H3,(H,25,26,27,28);1-2H2,(H,5,6)(H,7,8)
SMILES (canonical and isomeric)
CN(C)C(=O)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=NC=C(C=C4)N5CCNCC5.C(CC(=O)O)C(=O)O

Synonyms

  • LEE-011 succinate
  • Birociclib
  • Kisqali femara co-pack component ribociclib succinate
  • Ribociclib succinate component of kisqali femara co-pack
  • LEE011 succinate
  • 7-Cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide succinate
  • Kisqali
  • butanedioic acid, 7-cyclopentyl-N,N-dimethyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrrolo[2,3-d]pyrimidine-6-carboxamide
  • Ribociclib succinate (USAN)
  • 7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide, butanedioic acid
  • Kisqali (TN)
  • LEE011 succinate?
  • LEE-011 succinate salt, Ribociclib succinate salt
  • 7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide succinic acid
  • 7-cyclopentyl-N,N-dimethyl-2-[(5-piperazin-1-yl-2-pyridyl)amino]pyrrolo[2,3-d]pyrimidine-6-carboxamide, succinic acid
  • butanedioic acid, 7-cyclopentyl-N,N-dimethyl-2-[(5-piperazin-1-yl-2-pyridinyl)amino]pyrrolo[2,3-d]pyrimidine-6-carboxamide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
552.64 g/molcalc.
Exact mass
552.2809 Dacalc.
LogP (octanol/water)
2.73calc.
Topological polar surface area
165.8 Ųcalc.
Hydrogen bond donors
4calc.
Hydrogen bond acceptors
9calc.
Rotatable bonds
8calc.
Heavy atoms
40calc.
Rings
5calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.48calc.
Formal charge
0calc.
Stereocentres
0calc.
Components
2calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1cc(Nc2ncc3ccn(C4CCCC4)c3n2)ncc1N1CCNCC1

c1cc(Nc2ncc3ccn(C4CCCC4)c3n2)ncc1N1CCNCC1

5 rings, 27 atoms.

26 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H301Toxic if swallowed.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H360DMay damage the unborn child.
  • H373May cause damage to organs through prolonged or repeated exposure.
  • H411Toxic to aquatic life with long lasting effects.
Precautionary statements (20)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P302 + P352If on skin: Wash with plenty of water.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P391Collect spillage.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Ribociclib succinate suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 64 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

64 suppliers in 13 countries

Send one request to many suppliers

Choose up to 10 suppliers or let us match your request. Compare quotes side by side, free.

Choose suppliersPost a request

Ribociclib succinate price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

Get latest price

Uses and applications

What the substance is used for, by industry and function

Roles

  • antineoplastic agent
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Ribociclib succinate is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Ribociclib succinate is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Ribociclib succinate, based on the data on this page

What is Ribociclib succinate?

Ribociclib Succinate is the succinate salt form of ribociclib, an orally available inhibitor of the cyclin-dependent kinases (CDKs) 4 and 6, with antineoplastic activity. Upon oral administration, ribociclib specifically targets, binds to and inhibits CDK4 and CDK6.

What is the CAS number of Ribociclib succinate?

The CAS registry number of Ribociclib succinate is 1374639-75-4.

What is the molecular formula and weight of Ribociclib succinate?

The molecular formula of Ribociclib succinate is C27H36N8O5 and its molar mass is 552.64 g/mol.

What is Ribociclib succinate used for?

Known uses and roles of Ribociclib succinate include antineoplastic agent and pharmaceutical.

Is Ribociclib succinate hazardous?

Ribociclib succinate carries the GHS signal word "Danger". Main hazards: toxic if swallowed, causes skin irritation, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Ribociclib succinate?

Ribociclib succinate is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Ribociclib succinate?

CompoundList lists 64 suppliers of Ribociclib succinate in China, United States, India, United Kingdom and 9 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Ribociclib succinate in India?

8 suppliers in India list Ribociclib succinate on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Ribociclib succinate?

Suppliers quote Ribociclib succinate on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Ribociclib succinate

Get quotes for Ribociclib succinate

Post one free request with your grade, quantity and destination. Matching suppliers send quotes you can compare side by side.
Post a request Sell Ribociclib succinate
Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
Embed this structure on your websiteShow code

Paste this code into your page to show the 2D structure of Ribociclib succinate with a 3D view, its CAS number where known and a link back to this page. Free to use with the link kept.

<iframe src="https://www.compoundlist.com/embed/structure/ribociclib-succinate-1374639-75-4" title="Ribociclib succinate structure on CompoundList" width="360" height="420" style="border:1px solid #E7E2DA;border-radius:12px;max-width:100%" loading="lazy" referrerpolicy="strict-origin-when-cross-origin"></iframe>
Preview the embed

Explore more in Pharmaceuticals and APIs or HS code 293359

64 suppliers
Free quotes, contact stays private
Get quotes