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Murcko scaffold

Ring system with 5 rings and 27 atoms

27 chemicals on CompoundList share this ring system.

Rings: 5
Scaffold atoms: 27
Chemicals: 27
With full pages: 3

Scaffold SMILES

c1cc(Nc2ncc3ccn(C4CCCC4)c3n2)ncc1N1CCNCC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold c1cc(Nc2ncc3ccn(C4CCCC4)c3n2)ncc1N1CCNCC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 27 of 27 chemicals

Ribociclib chemical structure, C23H30N8O, CAS 1211441-98-3

CAS 1211441-98-3C₂₃H₃₀N₈O

7-Cyclopentyl-2-[[5-(3-methyl-1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carbonitrile chemical structure, C22H26N8, CAS 1211440-25-3

7-Cyclopentyl-2-[[5-(3-methyl-1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carbonitrile

CAS 1211440-25-3C₂₂H₂₆N₈

7-Cyclopentyl-2-{5-[4-(2-hydroxy-ethyl)-piperazin-1-yl]-pyridin-2-ylamino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide chemical structure, C25H34N8O2, CAS 1211440-85-5

7-Cyclopentyl-2-{5-[4-(2-hydroxy-ethyl)-piperazin-1-yl]-pyridin-2-ylamino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide

CAS 1211440-85-5C₂₅H₃₄N₈O₂

N-desmethyl Ribociclib chemical structure, C22H28N8O, CAS 1211441-59-6

N-desmethyl Ribociclib

CAS 1211441-59-6C₂₂H₂₈N₈O

Pyrrolo[2,3-d]pyrimidine derivative 9 chemical structure, C26H36N8O, CAS 1211441-71-2

Pyrrolo[2,3-d]pyrimidine derivative 9

CAS 1211441-71-2C₂₆H₃₆N₈O

7-Cyclopentyl-2-(5-(4-ethylpiperazin-1-yl)pyridin-2-ylamino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide chemical structure, C25H34N8O, CAS 1211442-07-7

7-Cyclopentyl-2-(5-(4-ethylpiperazin-1-yl)pyridin-2-ylamino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

CAS 1211442-07-7C₂₅H₃₄N₈O

Ribociclib D6 chemical structure, C23H30N8O, CAS 1328934-40-2

CAS 1328934-40-2C₂₃H₃₀N₈O

Ribociclib succinate chemical structure, C27H36N8O5, CAS 1374639-75-4

Ribociclib succinate

CAS 1374639-75-4C₂₇H₃₆N₈O₅

tert-Butyl 4-[6-[(7-cyclopentylpyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]piperazine-1-carboxylate chemical structure, C25H33N7O2, CAS 959798-79-9

tert-Butyl 4-[6-[(7-cyclopentylpyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]piperazine-1-carboxylate

CAS 959798-79-9C₂₅H₃₃N₇O₂

4-[6-(6-Cyano-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)-pyridin-3-yl]-2-methyl-piperazine-1-carboxylic acid tert-butyl ester chemical structure, C27H34N8O2, CAS 1211442-99-7

4-[6-(6-Cyano-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)-pyridin-3-yl]-2-methyl-piperazine-1-carboxylic acid tert-butyl ester

CAS 1211442-99-7C₂₇H₃₄N₈O₂

4-[6-(6-Cyano-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)-pyridin-3-yl]-piperazine-1-carboxylic acid tert-butyl ester chemical structure, C26H32N8O2, CAS 1211442-94-2

4-[6-(6-Cyano-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)-pyridin-3-yl]-piperazine-1-carboxylic acid tert-butyl ester

CAS 1211442-94-2C₂₆H₃₂N₈O₂

4-[6-(7-Cyclopentyl-6-dimethylcarbamoyl-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino) pyridin-3-yl]-2-methyl-piperazine-1-carboxylic acid tert-butyl ester chemical structure, C29H40N8O3, CAS 1211443-25-2

4-[6-(7-Cyclopentyl-6-dimethylcarbamoyl-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino) pyridin-3-yl]-2-methyl-piperazine-1-carboxylic acid tert-butyl ester

CAS 1211443-25-2C₂₉H₄₀N₈O₃

tert-Butyl 4-[6-[[7-cyclopentyl-6-(dimethylcarbamoyl)pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-pyridinyl]-2,6-dimethylpiperazine-1-carboxylate chemical structure, C30H42N8O3, CAS 1211443-84-3

tert-Butyl 4-[6-[[7-cyclopentyl-6-(dimethylcarbamoyl)pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-pyridinyl]-2,6-dimethylpiperazine-1-carboxylate

CAS 1211443-84-3C₃₀H₄₂N₈O₃

Ribociclib hydrochloride chemical structure, C23H31ClN8O, CAS 1211443-80-9

Ribociclib hydrochloride

CAS 1211443-80-9C₂₃H₃₁ClN₈O

tert-Butyl 4-(6-((7-cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo(2,3-d)pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate chemical structure, C28H38N8O3, CAS 1374639-78-7

tert-Butyl 4-(6-((7-cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo(2,3-d)pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate

CAS 1374639-78-7C₂₈H₃₈N₈O₃

7-Cyclopentyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic Acid chemical structure, C21H25N7O2, CAS 2762182-61-4

7-Cyclopentyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic Acid

CAS 2762182-61-4C₂₁H₂₅N₇O₂

tert-Butyl 4-[6-[[7-cyclopentyl-6-(methylcarbamoyl)pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-pyridinyl]piperazine-1-carboxylate chemical structure, C27H36N8O3, CAS 3066072-08-7

tert-Butyl 4-[6-[[7-cyclopentyl-6-(methylcarbamoyl)pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-pyridinyl]piperazine-1-carboxylate

CAS 3066072-08-7C₂₇H₃₆N₈O₃

LEE011 succinate hydrate chemical structure, C27H38N8O6, CAS 1374639-79-8

LEE011 succinate hydrate

CAS 1374639-79-8C₂₇H₃₈N₈O₆

Ribociclib pyridine N-oxide chemical structure, C23H30N8O2, CAS 2069953-39-3

Ribociclib pyridine N-oxide

CAS 2069953-39-3C₂₃H₃₀N₈O₂

Ribociclib impurity 44 chemical structure, C26H33N7O4, CAS 2250106-77-3

Ribociclib impurity 44

CAS 2250106-77-3C₂₆H₃₃N₇O₄

Ribociclib-d8 chemical structure, C23H30N8O, CAS 2167898-24-8

CAS 2167898-24-8C₂₃H₃₀N₈O

Ribociclib piperazine N1-oxide chemical structure, C23H30N8O2, CAS 2470164-21-5

Ribociclib piperazine N1-oxide

CAS 2470164-21-5C₂₃H₃₀N₈O₂

Ribociclib-d6 hydrochloride chemical structure, C23H31ClN8O, CAS 2934109-69-8

Ribociclib-d6 hydrochloride

CAS 2934109-69-8C₂₃H₃₁ClN₈O

7-Cyclopentyl-6-(dimethylcarbamoyl)-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine 7-Oxide chemical structure, C23H30N8O2, CAS 2514753-27-4

7-Cyclopentyl-6-(dimethylcarbamoyl)-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine 7-Oxide

CAS 2514753-27-4C₂₃H₃₀N₈O₂