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Screening compounds

Rogaratinib

Also known as 4-[[4-amino-6-(methoxymethyl)-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]methyl]piperazin-2-one, 2-Piperazinone, 4-((4-amino-6-(methoxymethyl)-5-(7-methoxy-5-methylbenzo(b)thien-2-yl)pyrrolo(2,1-f)(1,2,4)triazin-7-yl)methyl)-, 4-((4-Amino-6-(methoxymethyl)-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo(2,1-f)(1,2,4)triazin-7-yl)methyl)piperazin-2-one

CAS 1443530-05-9Formula C23H26N6O3SMolar mass 466.57 g/molEC 948-594-9
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Rogaratinib chemical structure, C23H26N6O3S, CAS 1443530-05-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
1443530-05-9
Formula
C23H26N6O3S
Molar mass
466.57 g/mol
EC number
948-594-9
HS code
293499
Category
Screening compounds

What is Rogaratinib?

Plain description, key identifiers and synonyms

Rogaratinib is a pan inhibitor of human fibroblast growth factor receptors (FGFRs) with potential antiangiogenic and antineoplastic activities. Rogaratinib inhibits the activities of FGFRs, which may result in the inhibition of both tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. FGFRs are a family of receptor tyrosine kinases, which may be upregulated in various tumor cell types and may be involved in tumor cell differentiation and proliferation, tumor angiogenesis, and tumor cell survival.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-[[4-amino-6-(methoxymethyl)-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]methyl]piperazin-2-one
CAS number
1443530-05-9
EC number
948-594-9
Molecular formula
C23H26N6O3S
UNII
98BSN6N516
MDL number
MFCD30533278
InChIKey
HNLRRJSKGXOYNO-UHFFFAOYSA-N
InChI
InChI=1S/C23H26N6O3S/c1-13-6-14-8-18(33-22(14)17(7-13)32-3)20-15(11-31-2)16(9-28-5-4-25-19(30)10-28)29-21(20)23(24)26-12-27-29/h6-8,12H,4-5,9-11H2,1-3H3,(H,25,30)(H2,24,26,27)
SMILES (canonical and isomeric)
CC1=CC2=C(C(=C1)OC)SC(=C2)C3=C4C(=NC=NN4C(=C3COC)CN5CCNC(=O)C5)N

Synonyms

  • 4-[[4-amino-6-(methoxymethyl)-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]methyl]piperazin-2-one
  • 2-Piperazinone, 4-((4-amino-6-(methoxymethyl)-5-(7-methoxy-5-methylbenzo(b)thien-2-yl)pyrrolo(2,1-f)(1,2,4)triazin-7-yl)methyl)-
  • 4-((4-Amino-6-(methoxymethyl)-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo(2,1-f)(1,2,4)triazin-7-yl)methyl)piperazin-2-one
  • 4-((4-amino-6-(methoxymethyl)-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo(2,1-f)(1,2,4)triazin-7-yl)methyl)-2-piperazinone
  • 4-{[4-amino-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)-6-(methoxymethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]methyl}piperazin-2-one
  • rogaratinibum
  • 4-((4-amino-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)-6-(methoxymethyl)pyrrolo(2,1-f)(1,2,4)triazin-7-yl)methyl)piperazin-2-one
  • 4-[[4-Amino-6-(methoxymethyl)-5-(7-methoxy-5-methylbenzo[b]thien-2-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]methyl]-2-piperazinone
  • Rogaratinib?
  • Example 1
  • BAY 1163877
  • US9206184, 1
  • US9206184, 2
  • 4-((4-amino-5-(7-methoxy-5-methylbenzo[b]thiophen-2-yl)-6-(methoxymethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)methyl)piperazin-2-one
  • 4-[[4-amino-6-(methoxymethyl)-5-(7-methoxy-5-methyl-benzothiophen-2-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]methyl]piperazin-2-one

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
466.57 g/molcalc.
Exact mass
466.1787 Dacalc.
LogP (octanol/water)
2.59calc.
Topological polar surface area
107 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
8calc.
Rotatable bonds
6calc.
Heavy atoms
33calc.
Rings
5calc.
Aromatic rings
4calc.
Fraction sp3 carbons
0.35calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CN(Cc2cc(-c3cc4ccccc4s3)c3cncnn23)CCN1

O=C1CN(Cc2cc(-c3cc4ccccc4s3)c3cncnn23)CCN1

5 rings, 26 atoms.

1 other chemical share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Rogaratinib suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 2 suppliers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

2 suppliers in 2 countries

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Rogaratinib price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antineoplastic agent
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Rogaratinib is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Rogaratinib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Rogaratinib, based on the data on this page

What is Rogaratinib?

Rogaratinib is a pan inhibitor of human fibroblast growth factor receptors (FGFRs) with potential antiangiogenic and antineoplastic activities. Rogaratinib inhibits the activities of FGFRs, which may result in the inhibition of both tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death.

What is the CAS number of Rogaratinib?

The CAS registry number of Rogaratinib is 1443530-05-9.

What is the molecular formula and weight of Rogaratinib?

The molecular formula of Rogaratinib is C23H26N6O3S and its molar mass is 466.57 g/mol.

What is Rogaratinib used for?

Known uses and roles of Rogaratinib include building blocks in research and laboratory, screening compounds in research and laboratory, antineoplastic agent and pharmaceutical.

Is Rogaratinib hazardous?

No GHS hazard classification for Rogaratinib is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Rogaratinib?

Rogaratinib is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Rogaratinib?

CompoundList lists 2 suppliers of Rogaratinib in Canada and Japan. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Rogaratinib?

Suppliers quote Rogaratinib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Rogaratinib

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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