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Heterocyclic building blocks

Rolipram

Also known as (R,S)-rolipram, 4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one, ZK 62711

CAS 61413-54-5Formula C16H21NO3Molar mass 275.35 g/molEC 262-771-1
GHS signal word: Warning. Pictograms: Harmful or irritant 90 suppliers listed
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Rolipram chemical structure, C16H21NO3, CAS 61413-54-5
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
61413-54-5
Formula
C16H21NO3
Molar mass
275.35 g/mol
EC number
262-771-1
HS code
293379
Category
Heterocyclic building blocks

What is Rolipram?

Plain description, key identifiers and synonyms

Rolipram is a member of the lclass of pyrrolidin-2-ones that is pyrrolidin-2-one bearing a 3-(cyclopentyloxy)-4-methoxyphenyl substituent at the 4-position. It is a type IV-specific phosphodiesterase (PDE4) inhibitor. It has a role as an antidepressant and an EC 3.1.4.* (phosphoric diester hydrolase) inhibitor.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one
CAS number
61413-54-5 CAS number cross-checked
EC number
262-771-1
Molecular formula
C16H21NO3
UNII
K676NL63N7
MDL number
MFCD00270906
InChIKey
HJORMJIFDVBMOB-UHFFFAOYSA-N
InChI
InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)
SMILES (canonical and isomeric)
COC1=C(C=C(C=C1)C2CC(=O)NC2)OC3CCCC3

Synonyms

  • (R,S)-rolipram
  • 4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one
  • ZK 62711
  • Rolipramum
  • 4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone
  • 4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one
  • 4-(3-(Cyclopentyloxy)-4-methoxyphenyl)-2-pyrrolidinone
  • ZK 62 711
  • (+-)-rolipram
  • Pyrrolidone, 4-(3-cyclopentyloxy-4-methoxyphenyl)-2-
  • (+/-)-Rolipram
  • 4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one
  • Adeo
  • 4-(3-Cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidone
  • 2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-
  • 4-[3-(cyclopentoxy)-4-methoxy-phenyl]pyrrolidin-2-one
  • (R,S)-Rolipram, SB 95952, ZK 62711
  • 4-(3-Cyclopentyloxy-4-methoxy-phenyl)-pyrrolidin-2-one
  • 2-Pyrrolidinone, 4-(3-(cyclopentyloxy)-4-methoxyphenyl)-
  • (4R)-4-[3-(Cyclopentyloxy)-4 Methoxyphenyl)pyrrolidin-2-one
  • [3H]rolipram
  • [3H]-rolipram
  • SB 95952
  • Rolipram?
  • (plusmn)-rolipram
Show all 28 synonyms
  • Rolipram (Standard)
  • Rolipram (JAN/USAN/INN)
  • (4S)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-pyrrolidin-2-one

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
275.35 g/molcalc.
Exact mass
275.1521 Dacalc.
LogP (octanol/water)
2.62calc.
Topological polar surface area
47.56 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
4calc.
Heavy atoms
20calc.
Rings
3calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.56calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CC(c2cccc(OC3CCCC3)c2)CN1

O=C1CC(c2cccc(OC3CCCC3)c2)CN1

3 rings, 18 atoms.

6 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (19)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Rolipram suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 90 suppliers
30 of 30 offers
  • Shanghaizehan biopharma technology co., Ltd
    China, ShanghaiUnclaimed profile
    RolipramGrade, purity and minimum order on request
    Price on request
    View
  • 001Chemical
    China, HangzhouUnclaimed profile
    RolipramGrade, purity and minimum order on request
    Price on request
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  • 10X Chem
    United States, San DiegoUnclaimed profile
    RolipramGrade, purity and minimum order on request
    Price on request
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  • 3WAY Pharm Inc
    China, ShanghaiUnclaimed profile
    RolipramGrade, purity and minimum order on request
    Price on request
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  • A2B Chem LLC
    United States, San DiegoUnclaimed profile
    RolipramGrade, purity and minimum order on request
    Price on request
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  • Aa Blocks LLC
    United States, San DiegoUnclaimed profile
    RolipramGrade, purity and minimum order on request
    Price on request
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  • Aaron Chemicals LLC.
    China, NanjingUnclaimed profile
    RolipramGrade, purity and minimum order on request
    Price on request
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  • AbaChemScene, LLC
    United States, Monmouth JunctionUnclaimed profile
    RolipramGrade, purity and minimum order on request
    Price on request
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  • Abmole Bioscience Inc.
    United States, HoustonUnclaimed profile
    RolipramGrade, purity and minimum order on request
    Price on request
    View
  • Accel Scientific S.L.
    Spain, BarcelonaUnclaimed profile
    RolipramGrade, purity and minimum order on request
    Price on request
    View

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

90 suppliers in 13 countries

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Rolipram price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Antidepressive Agents
  • Phosphodiesterase 4 Inhibitors

Roles

  • antidepressant
  • central nervous system drug
  • enzyme inhibitor
  • immunomodulator
  • immunosuppressive agent
  • pharmaceutical
  • psychotropic drug

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Rolipram is traded under.

HS 2933.79Indicative HS code

Lactams, other lactams

World exports in 2024
$16.2B
−64.4% vs 2023, imports $15.4B
2019 to 2024
Top exporters
  1. Ireland37.0%
  2. France * partner reported15.6%
  3. Spain11.3%
Top importers
  1. Germany27.8%
  2. Ireland18.9%
  3. Panama * partner reported12.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Rolipram is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Rolipram, based on the data on this page

What is Rolipram?

Rolipram is a member of the lclass of pyrrolidin-2-ones that is pyrrolidin-2-one bearing a 3-(cyclopentyloxy)-4-methoxyphenyl substituent at the 4-position. It is a type IV-specific phosphodiesterase (PDE4) inhibitor. It has a role as an antidepressant and an EC 3.1.4.* (phosphoric diester hydrolase) inhibitor.

What is the CAS number of Rolipram?

The CAS registry number of Rolipram is 61413-54-5.

What is the molecular formula and weight of Rolipram?

The molecular formula of Rolipram is C16H21NO3 and its molar mass is 275.35 g/mol.

What is Rolipram used for?

Known uses and roles of Rolipram include building blocks in research and laboratory, screening compounds in research and laboratory, antidepressant, central nervous system drug, enzyme inhibitor and 6 more.

Is Rolipram hazardous?

Rolipram carries the GHS signal word "Warning". Main hazards: harmful if swallowed, causes skin irritation, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Rolipram?

Rolipram is usually classified under HS code 293379 (Lactams, other lactams). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Rolipram?

CompoundList lists 90 suppliers of Rolipram in United States, China, United Kingdom, Germany and 9 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Rolipram?

Suppliers quote Rolipram on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Rolipram

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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