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Heterocyclic building blocks

(-)-Rolipram

Also known as (R)-(-)-Rolipram, (R)-Rolipram, (4R)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one

CAS 85416-75-7Formula C16H21NO3Molar mass 275.35 g/mol
4 suppliers listed
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(-)-Rolipram chemical structure, C16H21NO3, CAS 85416-75-7
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
85416-75-7
Formula
C16H21NO3
Molar mass
275.35 g/mol
HS code
293379
Category
Heterocyclic building blocks

What is (-)-Rolipram?

Plain description, key identifiers and synonyms

(-)-rolipram is the (R)-enantiomer of rolipram. It is an enantiomer of a (+)-rolipram.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(4R)-4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one
CAS number
85416-75-7
Molecular formula
C16H21NO3
UNII
DPX51KUP08
MDL number
MFCD03093860
InChIKey
HJORMJIFDVBMOB-LBPRGKRZSA-N
InChI
InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)/t12-/m0/s1
Canonical SMILES
COc1ccc(C2CNC(=O)C2)cc1OC1CCCC1
Isomeric SMILES
COC1=C(C=C(C=C1)[C@H]2CC(=O)NC2)OC3CCCC3

Synonyms

  • (R)-(-)-Rolipram
  • (R)-Rolipram
  • (4R)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one
  • R-Rolipram
  • Rolipram, (R)-
  • Rolipram, (-)-
  • (R)-4-(3-Cyclopentyloxy-4-methoxy-phenyl)-pyrrolidin-2-one
  • 2-Pyrrolidinone, 4-(3-(cyclopentyloxy)-4-methoxyphenyl)-, (R)-
  • (4R)-4-(3-(Cyclopentyloxy)-4-methoxyphenyl)-2-pyrrolidinone
  • 2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-, (4R)-
  • 2-Pyrrolidinone, 4-(3-(cyclopentyloxy)-4-methoxyphenyl)-, (4R)-
  • (4R)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one
  • (R)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one
  • R-(-)-Rolipram
  • (4R)-4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one
  • 4R)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one
  • 1xmy
  • Tocris-0905
  • Tocris-1349
  • Tocris-1350
  • 1q9m
  • 1ro6
  • 3g4k
  • (R)-Rolipram, (-)-Rolipram
  • (4R)-4-[3-(cyclopentoxy)-4-methoxy-phenyl]pyrrolidin-2-one
Show all 27 synonyms
  • (4R)-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone
  • (R)-(-)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
275.35 g/molcalc.
Exact mass
275.1521 Dacalc.
LogP (octanol/water)
2.62calc.
Topological polar surface area
47.56 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
4calc.
Heavy atoms
20calc.
Rings
3calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.56calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CC(c2cccc(OC3CCCC3)c2)CN1

O=C1CC(c2cccc(OC3CCCC3)c2)CN1

3 rings, 18 atoms.

6 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

(-)-Rolipram suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 4 suppliers
4 of 4 offers
  • Aceschem Inc
    United States, FriscoUnclaimed profile
    (-)-RolipramGrade, purity and minimum order on request
    Price on request
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  • Axon Medchem
    United States, RestonUnclaimed profile
    (-)-RolipramGrade, purity and minimum order on request
    Price on request
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  • Hello Bio
    United Kingdom, AvonmouthUnclaimed profile
    (-)-RolipramGrade, purity and minimum order on request
    Price on request
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  • Specs
    Netherlands, ZoetermeerUnclaimed profile
    (-)-RolipramGrade, purity and minimum order on request
    Price on request
    View

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

4 suppliers in 3 countries

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(-)-Rolipram price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code (-)-Rolipram is traded under.

HS 2933.79Indicative HS code

Lactams, other lactams

World exports in 2024
$16.2B
−64.4% vs 2023, imports $15.4B
2019 to 2024
Top exporters
  1. Ireland37.0%
  2. France * partner reported15.6%
  3. Spain11.3%
Top importers
  1. Germany27.8%
  2. Ireland18.9%
  3. Panama * partner reported12.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for (-)-Rolipram is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about (-)-Rolipram, based on the data on this page

What is (-)-Rolipram?

(-)-rolipram is the (R)-enantiomer of rolipram. It is an enantiomer of a (+)-rolipram.

What is the CAS number of (-)-Rolipram?

The CAS registry number of (-)-Rolipram is 85416-75-7.

What is the molecular formula and weight of (-)-Rolipram?

The molecular formula of (-)-Rolipram is C16H21NO3 and its molar mass is 275.35 g/mol.

What is (-)-Rolipram used for?

Known uses and roles of (-)-Rolipram include building blocks in research and laboratory and screening compounds in research and laboratory.

Is (-)-Rolipram hazardous?

No GHS hazard classification for (-)-Rolipram is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of (-)-Rolipram?

(-)-Rolipram is usually classified under HS code 293379 (Lactams, other lactams). This is indicative, confirm it with your customs broker before shipping.

Where can I buy (-)-Rolipram?

CompoundList lists 4 suppliers of (-)-Rolipram in United States, United Kingdom and Netherlands. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of (-)-Rolipram?

Suppliers quote (-)-Rolipram on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle (-)-Rolipram

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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