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Heterocyclic building blocks

Semaxanib

Also known as SU 5416, Semoxind, Semaxanib (SU5416)

CAS 194413-58-6Formula C15H14N2OMolar mass 238.29 g/mol
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Semaxanib chemical structure, C15H14N2O, CAS 194413-58-6
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
194413-58-6
Formula
C15H14N2O
Molar mass
238.29 g/mol
HS code
293379
Category
Heterocyclic building blocks

What is Semaxanib?

Plain description, key identifiers and synonyms

Semaxanib is an oxindole that is 3-methyleneoxindole in which one of the hydrogens of the methylene group is replaced by a 3,5-dimethylpyrrol-2-yl group. It has a role as an antineoplastic agent, an angiogenesis modulating agent, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor and a vascular endothelial growth factor receptor antagonist. It is a member of pyrroles, a member of oxindoles and an olefinic compound. It is functionally related to a 3-methyleneoxindole.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one
CAS number
194413-58-6 CAS number cross-checkedOther or deprecated CAS: 204005-46-9
Molecular formula
C15H14N2O
UNII
71IA9S35AJ
MDL number
MFCD01940922, MFCD09763655
InChIKey
WUWDLXZGHZSWQZ-WQLSENKSSA-N
InChI
InChI=1S/C15H14N2O/c1-9-7-10(2)16-14(9)8-12-11-5-3-4-6-13(11)17-15(12)18/h3-8,16H,1-2H3,(H,17,18)/b12-8-
Canonical SMILES
Cc1cc(C)c(C=C2C(=O)Nc3ccccc32)[nH]1
Isomeric SMILES
CC1=CC(=C(N1)/C=C\2/C3=CC=CC=C3NC2=O)C

Synonyms

  • SU 5416
  • Semoxind
  • Semaxanib (SU5416)
  • TSU 16
  • (Z)-3-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)indolin-2-one
  • (3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one
  • Z-Semaxanib
  • (Z)-SU 5416
  • 3-(1-(3,5-Dimethyl-1H-pyrrol-2-yl)meth-(Z)-ylidene)-2-oxo-2,3-dihydroindole
  • 3-[(2,4-Dimethylpyrrol-5-yl)methylidenyl]-2-indolinon
  • 3-((Z)-(3,5-Dimethylpyrrol-2-yl)methylene)-2-indolinone
  • (3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]indolin-2-one
  • 3-[(3,5-dimethyl-1h-pyrrol-2-yl)methylene]-1,3-dihydro-2h-indol-2-one
  • (3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1,3-dihydro-2H-indol-2-one
  • (3Z)-3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylidene]-2,3-dihydro-1H-indol-2-one
  • 3-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)indolin-2-one
  • Semaxnib
  • (Z)-Semaxinib
  • VEGF Receptor 2 Kinase Inhibitor III
  • 1,3-Dihydro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-2H-indol-2-one
  • 2H-Indol-2-one, 3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-
  • Semaxanib (USAN/INN)
  • methylene]-2H-indol-2-one
  • test2
  • (3Z)-3-((3,5-Dimethyl-1H-pyrrol-2-yl)methylidene)-1,3-dihydro-2H-indol-2-one
Show all 32 synonyms
  • (Z)-Semaxanib
  • 2x2m
  • Semaxanib, SU5416
  • Semaxanib (SU5416)?
  • H-Indol-2-one, 3-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-1,3-dihydro-
  • 1,3-Dihydro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)
  • 3-(2,4-dimethylpyrrol-5-yl)methylidene-indolin-2-one

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
238.29 g/molcalc.
Exact mass
238.1106 Dacalc.
LogP (octanol/water)
3.12calc.
Topological polar surface area
44.89 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
1calc.
Rotatable bonds
1calc.
Heavy atoms
18calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.13calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1Nc2ccccc2C1=Cc1ccc[nH]1

O=C1Nc2ccccc2C1=Cc1ccc[nH]1

3 rings, 16 atoms, the 3-(1H-Pyrrol-2-ylmethylidene)-1H-indol-2-one ring system.

102 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Semaxanib suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 5 suppliers
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Where suppliers are based

5 suppliers in 1 country

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Semaxanib price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • angiogenesis modulating agent
  • antagonist
  • antineoplastic agent
  • enzyme inhibitor
  • pharmaceutical
  • protein kinase inhibitor
  • tyrosine kinase inhibitor
  • vascular endothelial growth factor receptor antagonist

Pharmacology

Semaxanib is a quinolone derivative with potential antineoplastic activity. Semaxanib reversibly inhibits ATP binding to the tyrosine kinase domain of vascular endothelial growth factor receptor 2 (VEGFR2), which may inhibit VEGF-stimulated endothelial cell migration and proliferation and reduce the tumor microvasculature. This agent also inhibits the phosphorylation of the stem cell factor receptor tyrosine kinase c-kit, often expressed in acute myelogenous leukemia cells.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Semaxanib is traded under.

HS 2933.79Indicative HS code

Lactams, other lactams

World exports in 2024
$16.2B
−64.4% vs 2023, imports $15.4B
2019 to 2024
Top exporters
  1. Ireland37.0%
  2. France * partner reported15.6%
  3. Spain11.3%
Top importers
  1. Germany27.8%
  2. Ireland18.9%
  3. Panama * partner reported12.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Semaxanib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Semaxanib, based on the data on this page

What is Semaxanib?

Semaxanib is an oxindole that is 3-methyleneoxindole in which one of the hydrogens of the methylene group is replaced by a 3,5-dimethylpyrrol-2-yl group.

What is the CAS number of Semaxanib?

The CAS registry number of Semaxanib is 194413-58-6. Other or deprecated CAS numbers: 204005-46-9.

What is the molecular formula and weight of Semaxanib?

The molecular formula of Semaxanib is C15H14N2O and its molar mass is 238.29 g/mol.

What is Semaxanib used for?

Known uses and roles of Semaxanib include building blocks in research and laboratory, screening compounds in research and laboratory, angiogenesis modulating agent, antagonist, antineoplastic agent and 5 more.

Is Semaxanib hazardous?

No GHS hazard classification for Semaxanib is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Semaxanib?

Semaxanib is usually classified under HS code 293379 (Lactams, other lactams). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Semaxanib?

CompoundList lists 5 suppliers of Semaxanib in China. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Semaxanib?

Suppliers quote Semaxanib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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