Murcko scaffold
3-(1H-Pyrrol-2-ylmethylidene)-1H-indol-2-one scaffold
103 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 16
- Chemicals
- 103
- With full pages
- 21
Scaffold SMILES
O=C1Nc2ccccc2C1=Cc1ccc[nH]1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
![Murcko scaffold O=C1Nc2ccccc2C1=Cc1ccc[nH]1](/scaffold/SEZFNTZQMWJIAI-UHFFFAOYSA-N/structure.svg)
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 103 chemicals
3-(1H-Pyrrol-2-ylmethylidene)-1H-indol-2-one
CAS 91822-51-4C13H10N2O
Semaxinib
CAS 204005-46-9C15H14N2O
3-(2,4-Dimethyl-5-((2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid
CAS 1044712-39-1C18H18N2O3
N-(2-(Diethylamino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide
CAS 342641-94-5C22H27FN4O2
Su5402
CAS 215543-92-3C17H16N2O3
Semaxanib
CAS 194413-58-6C15H14N2O
Orantinib
CAS 252916-29-3C18H18N2O3
![N-[2-(Diethylamino)ethyl]-2,4-dimethyl-5-{[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-1H-pyrrole-3-carboxamide chemical structure, C22H28N4O2, CAS 326914-09-4](/s/UJGXTMZILSGDLG-LGMDPLHJSA-N.svg)
N-[2-(Diethylamino)ethyl]-2,4-dimethyl-5-{[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-1H-pyrrole-3-carboxamide
CAS 326914-09-4C22H28N4O2
Sunitinib
CAS 557795-19-4C22H27FN4O2
SU-11652
CAS 326914-10-7C22H27ClN4O2
N,N-Dimethyl sunitinib
CAS 326914-17-4C20H23FN4O2
![3-[5-[(Z)-(5-Bromo-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrol-3-yl]propanoic acid chemical structure, C18H17BrN2O3, CAS 251356-32-8](/s/CQXPYMNBBOWLME-ZSOIEALJSA-N.svg)
3-[5-[(Z)-(5-Bromo-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrol-3-yl]propanoic acid
CAS 251356-32-8C18H17BrN2O3
![(3E)-3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one chemical structure, C15H14N2O, CAS 194413-57-5](/s/WUWDLXZGHZSWQZ-XYOKQWHBSA-N.svg)
(3E)-3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one
CAS 194413-57-5C15H14N2O
(Z)-3-((1H-Pyrrol-2-yl)methylene)indolin-2-one
CAS 210303-07-4C13H10N2O
![(3Z)-3-[[4-(2-Chloroacetyl)-1H-pyrrol-2-yl]methylidene]-1H-indol-2-one chemical structure, C15H11ClN2O2, CAS 866038-33-7](/s/TXAORZNEFJVBGJ-SDQBBNPISA-N.svg)
(3Z)-3-[[4-(2-Chloroacetyl)-1H-pyrrol-2-yl]methylidene]-1H-indol-2-one
CAS 866038-33-7C15H11ClN2O2
![3-[2,4-Dimethyl-5-[(E)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid chemical structure, C18H18N2O3, CAS 245036-27-5](/s/NHFDRBXTEDBWCZ-NTEUORMPSA-N.svg)
3-[2,4-Dimethyl-5-[(E)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid
CAS 245036-27-5C18H18N2O3
Vegf receptor 2 kinase inhibitor I
CAS 15966-93-5C18H18N2O3
Sunitinib malate
CAS 341031-54-7C26H33FN4O7
(E)-Sunitinib
CAS 1691223-83-2C22H27FN4O2
![(3Z)-3-[(1-Methylpyrrol-2-yl)methylidene]-1H-indol-2-one chemical structure, C14H12N2O, CAS 210303-56-3](/s/WSUCIBGSTGQSRL-XFXZXTDPSA-N.svg)
(3Z)-3-[(1-Methylpyrrol-2-yl)methylidene]-1H-indol-2-one
CAS 210303-56-3C14H12N2O
SU 5614
CAS 1055412-47-9C15H13ClN2O
3-(5-Methyl-2-(2-oxo-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrol-3-yl)propionicacid
CAS 515821-11-1C17H16N2O3
Sunitinib N-oxide
CAS 356068-99-0C22H27FN4O3
N-Desethyl sunitinib
CAS 356068-97-8C20H23FN4O2
- 3 suppliersSunitinib acid356068-93-4C16H13FN2O3
- Methyl 3-[2,4-dimethyl-5-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoate548740-24-5C19H20N2O3
- 5-[(Z)-(5-Chloro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid356069-14-2C16H13ClN2O3
- [(3Z)-3-{1-[4-(Aminomethyl)-1H-pyrrol-2-yl]ethylidene}-2-oxo-2,3-dihydro-1H-indol-5-yl]urea1056225-52-5C16H17N5O2
- BX-517946843-63-6C15H14N4O2
- SU-014335873077-70-4C18H19FN4O2
- 5-{[(3Z)-5-(Carbamoylamino)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-N-[2-(dimethylamino)ethyl]-1H-pyrrole-3-carboxamide1056224-81-7C19H22N6O3
- N-[(5-{1-[(3Z)-5-(carbamoylamino)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]ethyl}-1H-pyrrol-3-yl)methyl]acetamide1056225-57-0C18H19N5O3
- [(3Z)-2-Oxo-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-indol-5-yl]urea946843-47-6C14H12N4O2
- 3-(5-{[(3Z)-5-(Carbamoylamino)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-4-methyl-1H-pyrrol-3-yl)propanoic acid1056224-73-7C18H18N4O4
- 5-{[(3Z)-5-(Carbamoylamino)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-1H-pyrrole-3-carboxylic acid1056224-65-7C15H12N4O4
- 2-Amino-N-[(5-{1-[(3Z)-5-(carbamoylamino)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]ethyl}-1H-pyrrol-3-yl)methyl]acetamide1056225-81-0C18H20N6O3
- 3-(5-{[(3Z)-5-(Carbamoylamino)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrol-3-yl)propanoic acid1056224-77-1C19H20N4O4
- tert-Butyl (Z)-((5-(1-(2-oxo-5-ureidoindolin-3-ylidene)ethyl)-1H-pyrrol-3-yl)methyl)carbamate850717-37-2C21H25N5O4
- [(3Z)-2-Oxo-3-[1-(1H-pyrrol-2-yl)propylidene]-2,3-dihydro-1H-indol-5-yl]urea946843-64-7C16H16N4O2
- 1 suppliersSunitinib maleate1126641-10-8C26H31FN4O6
- N-(3-Aminopropyl)-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide916975-71-8C19H21FN4O2
- 6-Hydroxy-TSU-681035154-49-4C18H18N2O4
- 5-{[(3Z)-5-(Carbamoylamino)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-4-methyl-1H-pyrrole-3-carboxylic acid1056224-69-1C16H14N4O4
- (3Z)-3-[(3,5-Dimethyl-4-nitro-1H-pyrrol-2-yl)methylidene]-5-fluoro-1,3-dihydro-2H-indol-2-one1072331-71-5C15H12FN3O3
- 5-((Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide1186651-51-3C16H14FN3O2
- (Z)-6-(5-((5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamido)hexanoic acid1100214-49-0C22H24FN3O4
- Sunitinib-d41126721-79-6C22H27FN4O2
- N-(2-(Bis(1,1,2,2,2-pentadeuterioethyl)amino)ethyl)-5-((Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide1126721-82-1C22H27FN4O2
Related scaffolds
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