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Screening compounds

Sivelestat

Also known as Ono-5046, 2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetic acid, N-(2-(4-(2,2-Dimethylpropionyloxy)phenylsulfonylamino)benzoyl)aminoacetic acid

CAS 127373-66-4Formula C20H22N2O7SMolar mass 434.47 g/mol
9 suppliers listed
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Sivelestat chemical structure, C20H22N2O7S, CAS 127373-66-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
127373-66-4
Formula
C20H22N2O7S
Molar mass
434.47 g/mol
HS code
293590
Category
Screening compounds

What is Sivelestat?

Plain description, key identifiers and synonyms

Sivelestat is a N-acylglycine and a pivalate ester. It is functionally related to a N-benzoylglycine.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetic acid
CAS number
127373-66-4 CAS number cross-checked
Molecular formula
C20H22N2O7S
UNII
DWI62G0P59
MDL number
MFCD00889071
InChIKey
BTGNGJJLZOIYID-UHFFFAOYSA-N
InChI
InChI=1S/C20H22N2O7S/c1-20(2,3)19(26)29-13-8-10-14(11-9-13)30(27,28)22-16-7-5-4-6-15(16)18(25)21-12-17(23)24/h4-11,22H,12H2,1-3H3,(H,21,25)(H,23,24)
SMILES (canonical and isomeric)
CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)O

Synonyms

  • Ono-5046
  • 2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetic acid
  • N-(2-(4-(2,2-Dimethylpropionyloxy)phenylsulfonylamino)benzoyl)aminoacetic acid
  • Glycine, N-(2-(((4-(2,2-dimethyl-1-oxopropoxy)phenyl)sulfonyl)amino)benzoyl)-
  • 2-[(2-{4-[(2,2-dimethylpropanoyl)oxy]benzenesulfonamido}phenyl)formamido]acetic acid
  • sivelestatum
  • 2-((2-((4-(2,2-dimethylpropanoyloxy)phenyl)sulfonylamino)benzoyl)amino)acetic acid
  • 2-((2-(4-((2,2-dimethylpropanoyl)oxy)benzenesulfonamido)phenyl)formamido)acetic acid
  • Adalimumab54mg/ml
  • Propanoic acid, 2,2-dimethyl-, 4-[[[2-[[(carboxymethyl)amino]carbonyl]phenyl]amino]sulfonyl]phenyl ester
  • Sivelestat (ONO-5046)
  • (2-((4-(Pivaloyloxy)phenyl)sulfonamido)benzoyl)glycine
  • EI546, LY544349, ONO5046
  • 2,2-Dimethyl-propionic acid 4-[2-(carboxymethyl-carbamoyl)-phenylsulfamoyl]-phenyl ester
  • EI 546
  • Ono-EI-600
  • siberestat
  • LY 544349
  • Sivelestat (USAN/INN)
  • Adalimumab (anti-TNF-alpha)
  • US9073833, Sivelestat
  • o-(p-Hydroxybenzenesulfonamido)hippuric acid, pivalate (ester)
  • Adalimumab pound 54mg/ml pound(c)
  • Sdccgsbi-0633759.p001
  • ONO5046, LY544349, EI546
Show all 28 synonyms
  • N-(2-{4-[(2,2-Dimethylpropanoyl)oxy]benzene-1-sulfonamido}benzoyl)glycine
  • N-{2-[({4-[(2,2-Dimethylpropanoyl)oxy]phenyl}sulfonyl)amino]benzoyl}glycine sodium
  • 2,2-Dimethyl-propionic acid 4-[2-(carboxymethyl-carbamoyl)-phenylsulfamoyl]-phenyl ester(ONO-5046)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
434.47 g/molcalc.
Exact mass
434.1148 Dacalc.
LogP (octanol/water)
2.25calc.
Topological polar surface area
138.9 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
7calc.
Heavy atoms
30calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.25calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=S(=O)(Nc1ccccc1)c1ccccc1

O=S(=O)(Nc1ccccc1)c1ccccc1

2 rings, 16 atoms, the Benzenesulfonanilide ring system.

5,797 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Sivelestat suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 9 suppliers
9 of 9 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

9 suppliers in 3 countries

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Sivelestat price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Serine Proteinase Inhibitors

Roles

  • cardiovascular drug
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Sivelestat is traded under.

HS 2935.90Indicative HS code

Sulphonamides, other

World exports in 2024
$5.64B
−11.0% vs 2023, imports $8.56B
2019 to 2024
Top exporters
  1. Ireland43.1%
  2. China12.0%
  3. India * partner reported9.5%
Top importers
  1. United States23.6%
  2. Slovenia19.1%
  3. Spain11.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Sivelestat is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Sivelestat, based on the data on this page

What is Sivelestat?

Sivelestat is a N-acylglycine and a pivalate ester. It is functionally related to a N-benzoylglycine.

What is the CAS number of Sivelestat?

The CAS registry number of Sivelestat is 127373-66-4.

What is the molecular formula and weight of Sivelestat?

The molecular formula of Sivelestat is C20H22N2O7S and its molar mass is 434.47 g/mol.

What is Sivelestat used for?

Known uses and roles of Sivelestat include building blocks in research and laboratory, screening compounds in research and laboratory, cardiovascular drug, pharmaceutical and serine proteinase inhibitors.

Is Sivelestat hazardous?

No GHS hazard classification for Sivelestat is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Sivelestat?

Sivelestat is usually classified under HS code 293590 (Sulphonamides, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Sivelestat?

CompoundList lists 9 suppliers of Sivelestat in China, United States and Germany. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Sivelestat?

Suppliers quote Sivelestat on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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