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Peptides

Soblidotin

Also known as Auristatin PE, Tzt-1027, Soblidotina

CAS 149606-27-9Formula C39H67N5O6Molar mass 701.99 g/mol
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Soblidotin chemical structure, C39H67N5O6, CAS 149606-27-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
149606-27-9
Formula
C39H67N5O6
Molar mass
701.99 g/mol
HS code
293399
Category
Peptides

What is Soblidotin?

Plain description, key identifiers and synonyms

Soblidotin is a tetrapeptide derivative of dolastatin 10. It is an inhibitor of tubulin polymerization which exhibits potent antitumor activity. It has a role as an antineoplastic agent, a microtubule-destabilising agent and an apoptosis inducer. It is functionally related to a L-valine and a 2-phenylethylamine.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2S)-2-[[(2S)-2-(dimethylamino)-3-methylbutanoyl]amino]-N-[(3R,4S,5S)-3-methoxy-1-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-(2-phenylethylamino)propyl]pyrrolidin-1-yl]-5-methyl-1-oxoheptan-4-yl]-N,3-dimethylbutanamide
CAS number
149606-27-9 CAS number cross-checked
Molecular formula
C39H67N5O6
UNII
DQC51A0WQH
MDL number
MFCD09838692
InChIKey
DZMVCVHATYROOS-ZBFGKEHZSA-N
InChI
InChI=1S/C39H67N5O6/c1-13-27(6)35(43(10)39(48)33(25(2)3)41-38(47)34(26(4)5)42(8)9)31(49-11)24-32(45)44-23-17-20-30(44)36(50-12)28(7)37(46)40-22-21-29-18-15-14-16-19-29/h14-16,18-19,25-28,30-31,33-36H,13,17,20-24H2,1-12H3,(H,40,46)(H,41,47)/t27-,28+,30-,31+,33-,34-,35-,36+/m0/s1
Canonical SMILES
CCC(C)C(C(CC(=O)N1CCCC1C(OC)C(C)C(=O)NCCc1ccccc1)OC)N(C)C(=O)C(NC(=O)C(C(C)C)N(C)C)C(C)C
Isomeric SMILES
CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@@H](C)C(=O)NCCC2=CC=CC=C2)OC)OC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)N(C)C

Synonyms

  • Auristatin PE
  • Tzt-1027
  • Soblidotina
  • Soblidotine
  • Tzt 1027
  • soblidotinum
  • Auristatin PE, TZT-1027
  • Soblitodin

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
701.99 g/molcalc.
Exact mass
701.5091 Dacalc.
LogP (octanol/water)
3.99calc.
Topological polar surface area
120.5 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
7calc.
Rotatable bonds
20calc.
Heavy atoms
50calc.
Rings
2calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.74calc.
Formal charge
0calc.
Stereocentres
8calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(CCC1CCCN1)NCCc1ccccc1

O=C(CCC1CCCN1)NCCc1ccccc1

2 rings, 18 atoms.

46 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Soblidotin suppliers

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Soblidotin price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Antineoplastic Agents

Roles

  • antimitotic
  • antineoplastic agent
  • apoptosis inducer
  • microtubule-destabilising agent
  • pharmaceutical
  • tubulin modulator

Pharmacology

Soblidotin is a dolastatin-10 derivative. Soblidotin inhibits tubulin polymerization, resulting in cell cycle arrest and induction of apoptosis. (NCI04)

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Soblidotin is traded under.

HS 2933.99Indicative HS code

Heterocyclic compounds with nitrogen hetero-atom(s) only, other

World exports in 2024
$12.1B
−31.0% vs 2023, imports $28.8B
2019 to 2024
Top exporters
  1. China30.5%
  2. India * partner reported16.3%
  3. Ireland9.0%
Top importers
  1. Slovenia31.7%
  2. Italy24.2%
  3. United States5.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Soblidotin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Soblidotin, based on the data on this page

What is Soblidotin?

Soblidotin is a tetrapeptide derivative of dolastatin 10. It is an inhibitor of tubulin polymerization which exhibits potent antitumor activity. It has a role as an antineoplastic agent, a microtubule-destabilising agent and an apoptosis inducer. It is functionally related to a L-valine and a 2-phenylethylamine.

What is the CAS number of Soblidotin?

The CAS registry number of Soblidotin is 149606-27-9.

What is the molecular formula and weight of Soblidotin?

The molecular formula of Soblidotin is C39H67N5O6 and its molar mass is 701.99 g/mol.

What is Soblidotin used for?

Known uses and roles of Soblidotin include antimitotic, antineoplastic agent, apoptosis inducer, microtubule-destabilising agent, pharmaceutical and 2 more.

Is Soblidotin hazardous?

No GHS hazard classification for Soblidotin is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Soblidotin?

Soblidotin is usually classified under HS code 293399 (Heterocyclic compounds with nitrogen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Soblidotin?

Post a free request on CompoundList and suppliers of Soblidotin will send you quotes. Your contact details stay private until you accept a quote.

What is the price of Soblidotin?

Suppliers quote Soblidotin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Soblidotin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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