Sovleplenib
Also known as HMPL-523, HMPL523, compound 225
Key facts
What buyers check first
- CAS number
- 1415792-84-5
- Formula
- C24H30N6O3S
- Molar mass
- 482.61 g/mol
- HS code
- 293590
- Category
- Screening compounds
What is Sovleplenib?
Plain description, key identifiers and synonyms
Sovleplenib is an orally available inhibitor of spleen tyrosine kinase (Syk), with potential immunomodulating and antineoplastic activities. Upon oral administration of sovleplenib, this agent binds to and inhibits the activity of Syk. This inhibits B-cell receptor (BCR) signaling, which leads to the inhibition of B-cell activation, and prevents tumor cell activation, migration, adhesion and proliferation. Syk, a non-receptor cytoplasmic, BCR-associated tyrosine kinase, is expressed in hematopoietic tissues and is often overexpressed in hematopoietic malignancies, it plays a key role in B-cell receptor signaling.
Identifiers
Registry numbers, names and line notations, tap to copy
- IUPAC name
- 7-[4-(1-methylsulfonylpiperidin-4-yl)phenyl]-N-[[(2S)-morpholin-2-yl]methyl]pyrido[3,4-b]pyrazin-5-amine
- CAS number
- 1415792-84-5
- Molecular formula
- C24H30N6O3S
- UNII
- 9CL6353KHO
- MDL number
- MFCD34549487
- InChIKey
- NJIAKNWTIVDSDA-FQEVSTJZSA-N
- InChI
- InChI=1S/C24H30N6O3S/c1-34(31,32)30-11-6-18(7-12-30)17-2-4-19(5-3-17)21-14-22-23(27-9-8-26-22)24(29-21)28-16-20-15-25-10-13-33-20/h2-5,8-9,14,18,20,25H,6-7,10-13,15-16H2,1H3,(H,28,29)/t20-/m0/s1
- Canonical SMILES
- CS(=O)(=O)N1CCC(c2ccc(-c3cc4nccnc4c(NCC4CNCCO4)n3)cc2)CC1
- Isomeric SMILES
- CS(=O)(=O)N1CCC(CC1)C2=CC=C(C=C2)C3=CC4=NC=CN=C4C(=N3)NC[C@@H]5CNCCO5
Synonyms
- HMPL-523
- HMPL523
- compound 225
- (S)-7-(4-(1-(Methylsulfonyl)piperidin-4-yl)phenyl)-N-(morpholin-2-ylmethyl)pyrido(4,3-b)pyrazin-5-amine
- compound 225 (WO2012167733A1)
- Syk Inhibitor HMPL-523
- Spleen Tyrosine Kinase Inhibitor HMPL-523
- Hmpl 523
- (S)-7-(4-(1-(Methylsulfonyl)piperidin-4-yl)phenyl)-N-(morpholin-2-ylmethyl)pyrido[3,4-b]pyrazin-5-amine
- Pyrido[3,4-b]pyrazin-5-amine, 7-[4-[1-(methylsulfonyl)-4-piperidinyl]phenyl]-N-[(2S)-2-morpholinylmethyl]-
- 7-[4-(1-methylsulfonylpiperidin-4-yl)phenyl]-N-[[(2S)-morpholin-2-yl]methyl]pyrido[3,4-b]pyrazin-5-amine
- Sovleplenib (USAN/INN)
- 7-[4-[1-(Methylsulfonyl)-4-piperidinyl]phenyl]-N-[(2S)-2-morpholinylmethyl]pyrido[3,4-b]pyrazin-5-amine
- 7-{4-[1-(methanesulfonyl)piperidin-4-yl]phenyl}-N-{[(2S)-morpholin-2-yl]methyl}pyrido[3,4-b]pyrazin-5-amine
Physical and chemical properties
Measured values and descriptors computed from the structure
Physical and chemical properties
Measured values, check the supplier specification for your grade
No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.
Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.
Computed descriptors
Calculated from the structure, useful for screening and formulation
| Molecular weight | 482.61 g/molcalc.Computed value |
|---|---|
| Exact mass | 482.21 Dacalc.Computed value |
| LogP (octanol/water) | 2.23calc.Computed value |
| Topological polar surface area | 109.3 Ųcalc.Computed value |
| Hydrogen bond donors | 2calc.Computed value |
| Hydrogen bond acceptors | 8calc.Computed value |
| Rotatable bonds | 6calc.Computed value |
| Heavy atoms | 34calc.Computed value |
| Rings | 5calc.Computed value |
| Aromatic rings | 3calc.Computed value |
| Fraction sp3 carbons | 0.46calc.Computed value |
| Formal charge | 0calc.Computed value |
| Stereocentres | 1calc.Computed value |
| Lipinski rule of five | Passes (0 violations)calc.Computed value |
Calculated for screening. Confirm critical figures with the supplier.
Murcko scaffold
The ring system that remains when every side chain is removed
c1cnc2c(NCC3CNCCO3)nc(-c3ccc(C4CCNCC4)cc3)cc2n1
5 rings, 30 atoms.
1 other chemical share this scaffoldSafety and hazards
GHS classification summary, not a safety data sheet
No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.
GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.
Sovleplenib suppliers
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Sovleplenib price
Indicative price range per kg from live supplier offers
Suppliers quote this chemical on request. Send one free request and compare quotes side by side.
Uses and applications
What the substance is used for, by industry and function
Industries and functions
Regulatory status
Inventories, regulations and trade controls that list this substance
No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.
HS code and trade data
Customs classification and reported world trade statistics
Global trade
World import and export statistics for the HS code Sovleplenib is traded under.
Sulphonamides, other
- United States23.6%
- Slovenia19.1%
- Spain11.7%
* Partner reported figures, a lower bound.
The HS code shown for Sovleplenib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.
Related chemicals
Parent and salt forms, stereoisomers, similar structures and isomers
Salt and hydrate forms
Records that share this compound as their parent
Same formula isomers
Different compounds that share this molecular formula
![{3-[(2-{[3-Methanesulfonyl-5-(4-methylpiperazin-1-yl)phenyl]amino}-5-methylpyrimidin-4-yl)amino]phenyl}methanol chemical structure, C24H30N6O3S, CAS 2228908-74-3](/s/WKJVLTJTBZVAKC-UHFFFAOYSA-N.svg)
![N-Ethyl-1-(6-(2-((4-isopropylphenyl)amino)-2-oxoethyl)-7-oxo-6,7-dihydrothiazolo[4,5-d]pyrimidin-2-yl)piperidine-3-carboxamide chemical structure, C24H30N6O3S, CAS 1115899-38-1](/s/BCROSNMAWLVZTG-UHFFFAOYSA-N.svg)
![N-Ethyl-1-(7-oxo-6-{[(2,4,6-trimethylphenyl)carbamoyl]methyl}-6H,7H-[1,3]thiazolo[4,5-d]pyrimidin-2-yl)piperidine-3-carboxamide chemical structure, C24H30N6O3S, CAS 1116048-75-9](/s/QHQTWKJJDMBPAB-UHFFFAOYSA-N.svg)
![N-[4-({[5-(1,3-Benzodioxol-5-yl)-1,3,4-oxadiazol-2-yl]methyl}thio)phenyl]-3-methylthiophene-2-carboxamide chemical structure, C24H30N6O3S, CAS 1115982-58-5](/s/PBYSAGMPLMRUKR-UHFFFAOYSA-N.svg)
![Ethyl 4-(2-((4-isopropyl-1-(p-tolyl)-1H-pyrazolo[3,4-d]pyridazin-7-yl)thio)acetyl)piperazine-1-carboxylate chemical structure, C24H30N6O3S, CAS 1207029-69-3](/s/CESBHWCFGDZNDS-UHFFFAOYSA-N.svg)
![N-[3-[[(3,4-Dihydro-2H-pyrrol-5-yl)amino]sulfonyl]phenyl]-4,6-dimethyl-1-(1-methylethyl)-1H-pyrazolo[3,4-b]pyridine-5-propanamide chemical structure, C24H30N6O3S, CAS 878259-70-2](/s/DSKDDLLWIHIJLE-UHFFFAOYSA-N.svg)
Frequently asked questions
Quick answers about Sovleplenib, based on the data on this page
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Guides for buyers
Practical guides that help when you source, ship or handle Sovleplenib
- Guide, Chemical identityCAS registry numbers explainedWhat a CAS number identifies, how the check digit works, why one chemical can have several numbers and what a CAS number cannot tell you about a product.Read
- Article, SourcingHow to write an RFQ that gets fast and accurate quotesWhat suppliers need to quote quickly and comparably: exact product identity, quantity and packing, delivery terms, documents, samples and payment, with a ready to use template.Read
- Guide, Trade and logisticsHS codes for chemicals and why they matterHow the Harmonized System classifies chemicals, the chapters that matter, the rules for chemically defined compounds and mixtures, and practical steps to find the right code.Read
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