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Emollients

Squalene

Also known as Spinacene, trans-Squalene, All-trans-Squalene

CAS 111-02-4Formula C30H50Molar mass 410.73 g/molEC 203-826-1
GHS signal word: Danger. Pictograms: Serious health hazard 92 suppliers listed
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Squalene chemical structure, C30H50, CAS 111-02-4
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Oil, crystals from ether/methanol (-5 °C)
Melting point
-4.8 °C
Boiling point
421.3 °C
Density
0.8584 g/cm³ at 20 °C
Flash point
110 °C
HS code
290129
Category
Emollients
Illustrative photo, 25 litre white jerry cans of liquid in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Squalene?

Plain description, key identifiers and synonyms

Squalene is a triterpene consisting of 2,6,10,15,19,23-hexamethyltetracosane having six double bonds at the 2-, 6-, 10-, 14-, 18- and 22-positions with (all-E)-configuration. It has a role as a mouse metabolite, a Saccharomyces cerevisiae metabolite, a plant metabolite and a human metabolite.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
CAS number
111-02-4Other or deprecated CAS: 11051-27-7, 7683-64-9
EC number
203-826-1
Molecular formula
C30H50
UNII
7QWM220FJH
MDL number
MFCD00008912
INCI name
SQUALENE
InChIKey
YYGNTYWPHWGJRM-AAJYLUCBSA-N
InChI
InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+
Canonical SMILES
CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C
Isomeric SMILES
CC(=CCC/C(=C/CC/C(=C/CC/C=C(/CC/C=C(/CCC=C(C)C)\C)\C)/C)/C)C

Synonyms

  • Spinacene
  • trans-Squalene
  • All-trans-Squalene
  • (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
  • Spinacen
  • Nikko Squalane EX
  • Super Squalene
  • Squalen
  • (All-E)-2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaene
  • 2,6,10,15,19,23-Hexamethyl-2,6,10,14,18,22-tetracosahexaene
  • 2,6,10,14,18,22-Tetracosahexaene, 2,6,10,15,19,23-hexamethyl-, (all-E)-
  • 2,6,10,14,18,22-tetracosahexaene, 2,6,10,15,19,23-hexamethyl-, (6E,10E,14E,18E)-
  • 2,6,10,14,18,22-Tetracosahexaene, 2,6,10,15,19,23-hexamethyl-, (2E,6E,10E,14E,18E)-
  • Supraene
  • (E)-Squalene
  • (E,E,E,E)-Squalene
  • (E/Z)-Squalene
  • 2,6,10,14,18,22-Tetracosahexaene, 2,6,10,15,19,23-hexamethyl-
  • Squalene CRS
  • Super Squalene, trans-Squalene, AddaVax
  • Squalene (Standard)
  • Squalene, all-trans-
  • Squalene, Spinacene, Supraene
  • 2,6,10,15,19,23-Hexamethyl-2,6,10,14,18,22-tetracosahexene
  • QSPL 049
Show all 31 synonyms
  • Mf59 component squalene
  • Squalene 100 |Ig/mL in Hexane
  • Squalene 100 microg/mL in Hexane
  • 2,6,10,15,19,23-Hexamethyl-2,6,10,14,18,22-tetracosahexaene, (all-E)-
  • Montanide isa 720 component squalene
  • 2,6,10,14,18,22-tetracosahexaene, 2,6,10,15,19,23-hexamethyl-, (all E)-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Oil, crystals from ether/methanol (-5 °C)exp.
Odour
Faint agreeable odorexp.
Melting point
-4.8 °Cexp.
Boiling point
421.3 °Cexp.
Density
0.8584 g/cm³ at 20 °Cexp.
Flash point
110 °Cexp.
Solubility
Practically insoluble in water.exp.
Vapour pressure
2 [mm Hg] @240 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
410.73 g/molcalc.
Exact mass
410.3913 Dacalc.
LogP (octanol/water)
10.6calc.
Topological polar surface area
0 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
0calc.
Rotatable bonds
15calc.
Heavy atoms
30calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.6calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H304May be fatal if swallowed and enters airways.
Precautionary statements (4)
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P331Do not induce vomiting.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Squalene suppliers

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All 92 suppliers
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Where suppliers are based

92 suppliers in 17 countries

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Squalene price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Bactericide, intermediate in manufacture of pharmaceuticals, organic coloring materials, rubber chemicals, aromatics and surface active agents.

Biochemical and pharmaceutical research, a percursor of cholestrol in biosynthesis, chemical intermediate.

Squalane and Squalene have been identified as natural components of human sebum. Both ingredients are used in a variety of cosmetics at concentrations ranging from < or =0.1 to >50%.

Squalene is a polyunsaturated hydrocarbon with a formula of C30H50. Squalene can be found in certain fish oils, especially shark liver oil, in high amounts and some vegetable oils in relatively smaller amounts. Human sebum also contains 13% squalene as one of its major constituents. Squalane is a saturated derivative of squalene and also found in these sources.

Read more

Interest in squalene has been raised after its characterization in shark liver oil which is used as a traditional medicine for decades. Several studies exhibited results that prove certain bioactivities for squalene and squalane. Up to date, anticancer, antioxidant, drug carrier, detoxifier, skin hydrating, and emollient activities of these substances have been reported both in animal models and in vitro environments. According to promising results from recent studies, squalene and squalane are considered important substances in practical and clinical uses with a huge potential in nutraceutical and pharmaceutical industries.

Use classes: Cosmetics.

Cosmetic ingredient, INCI name SQUALENE(skin conditioning - emollient, hair conditioning, solvent)

Roles

  • Saccharomyces cerevisiae metabolite
  • animal metabolite
  • eukaryotic metabolite
  • fungal metabolite
  • human metabolite
  • mammalian metabolite
  • metabolite
  • mouse metabolite
  • plant metabolite

Functional uses

  • Anti-static agent
  • Softener and conditioner

Cosmetic functions

  • Hair conditioning
  • Skin conditioning - emollient
  • Solvent

How it is made

Squalene is commercially extracted from fish oil, and in particular shark liver oil. Squalene used in pharmaceutical products and vaccines is purified from this source.

Commercially available methods for squalene extraction from olive oil yield to a vegetable squalene with around 97.5% purity, while squalene obtained from shark liver oil can reach 99.9% purity.

Squalene is extracted from shark liver or synthesized from hexaphenyl-1,4-butanediyldiphosphonium dibromide and 6,10-dimethyl-5,9-undecadien-2-one (geranylacetone, industrial intermediate in the vitamin E synthesis).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Squalene is traded under.

HS 2901.29Indicative HS code

Unsaturated, other

World exports in 2024
$2.65B
−3.2% vs 2023, imports $2.57B
2019 to 2024
Top exporters
  1. United States43.9%
  2. South Africa15.3%
  3. Qatar * partner reported9.0%
Top importers
  1. Singapore10.9%
  2. United States10.1%
  3. South Korea8.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Squalene is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Squalene, based on the data on this page

What is Squalene?

Squalene is a triterpene consisting of 2,6,10,15,19,23-hexamethyltetracosane having six double bonds at the 2-, 6-, 10-, 14-, 18- and 22-positions with (all-E)-configuration. It has a role as a mouse metabolite, a Saccharomyces cerevisiae metabolite, a plant metabolite and a human metabolite.

What is the CAS number of Squalene?

The CAS registry number of Squalene is 111-02-4. Other or deprecated CAS numbers: 11051-27-7, 7683-64-9.

What is the molecular formula and weight of Squalene?

The molecular formula of Squalene is C30H50 and its molar mass is 410.73 g/mol.

What is Squalene used for?

Bactericide, intermediate in manufacture of pharmaceuticals, organic coloring materials, rubber chemicals, aromatics and surface active agents. Biochemical and pharmaceutical research, a percursor of cholestrol in biosynthesis, chemical intermediate.

Is Squalene hazardous?

Squalene carries the GHS signal word "Danger". Main hazards: may be fatal if swallowed and enters airways. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Squalene?

Squalene is usually classified under HS code 290129 (Unsaturated, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Squalene?

CompoundList lists 92 suppliers of Squalene in China, United States, Germany, United Kingdom and 13 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Squalene in India?

2 suppliers in India list Squalene on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Squalene?

Suppliers quote Squalene on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Squalene

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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