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Oncology and immunology drugs

Sunitinib

Also known as sunitinibum, N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide

CAS 557795-19-4Formula C22H27FN4O2Molar mass 398.48 g/molEC 111-194-2
GHS signal word: Warning. Pictograms: Serious health hazard, Hazardous to the environment 90 suppliers listed Drug substance
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Sunitinib chemical structure, C22H27FN4O2, CAS 557795-19-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
557795-19-4
Formula
C22H27FN4O2
Appearance
Orange solid
Solubility
Solubility at 22 °C (ug/mL): 2582 in 20 mM KCl/HCl buffer (pH 2), 364 in 20 mM phosphate…
HS code
293379
Category
Oncology and immunology drugs
Illustrative photo, closed white HDPE bottles and amber jars on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Sunitinib?

Plain description, key identifiers and synonyms

Sunitinib is a member of pyrroles and a monocarboxylic acid amide. It has a role as an antineoplastic agent, an angiogenesis inhibitor, an immunomodulator, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor, a neuroprotective agent and a vascular endothelial growth factor receptor antagonist. It is functionally related to a 3-methyleneoxindole.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
CAS number
557795-19-4 CAS number cross-checkedOther or deprecated CAS: 342641-94-5
EC number
111-194-2
Molecular formula
C22H27FN4O2
UNII
V99T50803M
MDL number
MFCD09260778
InChIKey
WINHZLLDWRZWRT-ATVHPVEESA-N
InChI
InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12-
Canonical SMILES
CCN(CC)CCNC(=O)c1c(C)[nH]c(C=C2C(=O)Nc3ccc(F)cc32)c1C
Isomeric SMILES
CCN(CC)CCNC(=O)C1=C(NC(=C1C)/C=C\2/C3=C(C=CC(=C3)F)NC2=O)C

Synonyms

  • sunitinibum
  • N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide
  • N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
  • n-(2-(diethylamino)ethyl)-5-((z)-(5-fluoro-1,2-dihydro-2-oxo-3h-indol-3-ylidene)methyl)-2,4-dimethyl-1h-pyrrole-3-carboxamide
  • 1H-Pyrrole-3-carboxamide, N-(2-(diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-
  • N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
  • N-(2-(Diethylamino)ethyl)-5-((Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide
  • 1H-Pyrrole-3-carboxamide, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-
  • N-(2-(diethylamino)ethyl)-5-(((3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide
  • N-(2-(diethylamino)ethyl)-5-((Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide
  • 5-(5-fluoro-2-oxo-1,2-dihydroindolylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide
  • Sutent
  • Sunitinib Base
  • N-(2-(Diethylamino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide
  • (Z)-N-(2-(Diethylamino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide
  • Sunitinib (INN)
  • SU 11248
  • Sunitinib (free base)
  • Sunitinib base?
  • (Z)-Sunitinib
  • 5-(5-fluoro-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylamino-ethyl)-amide
  • 5-[5-fluoro-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylamino-ethyl)-amide
  • Sutent (free base)
  • Sunitinib (Standard)
  • Sunitinib Impurity 23(Sunitinib Mixture Of E And Z Isomer)
Show all 27 synonyms
  • Sutent, Sunitinib, SU11248
  • 1H-Pyrrole-3-carboxamide,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Orange solidexp.
Solubility
Solubility at 22 °C (ug/mL): 2582 in 20 mM KCl/HCl buffer (pH 2), 364 in 20 mM phosphate buffer (pH 6)exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
398.48 g/molcalc.
Exact mass
398.2118 Dacalc.
LogP (octanol/water)
3.33calc.
Topological polar surface area
77.23 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
7calc.
Heavy atoms
29calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.36calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1Nc2ccccc2C1=Cc1ccc[nH]1

O=C1Nc2ccccc2C1=Cc1ccc[nH]1

3 rings, 16 atoms, the 3-(1H-Pyrrol-2-ylmethylidene)-1H-indol-2-one ring system.

102 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS08: Serious health hazard
Serious health hazard
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H361dSuspected of damaging the unborn child.
  • H373May cause damage to organs through prolonged or repeated exposure.
  • H400Very toxic to aquatic life.
  • H410Very toxic to aquatic life with long lasting effects.
Precautionary statements (9)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P391Collect spillage.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Sunitinib suppliers

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Where suppliers are based

90 suppliers in 16 countries

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Sunitinib price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Angiogenesis Inhibitors
  • Antineoplastic Agents
  • Protein Kinase Inhibitors

Roles

  • angiogenesis inhibitor
  • antagonist
  • antimicrobial agent
  • antineoplastic agent
  • antiviral agent
  • enzyme inhibitor
  • immunomodulator
  • neuroprotective agent
  • pharmaceutical
  • protective agent
  • protein kinase inhibitor
  • renoprotective agent
  • tyrosine kinase inhibitor
  • vascular endothelial growth factor receptor antagonist

Pharmacology

Sunitinib is a Kinase Inhibitor. The mechanism of action of sunitinib is as a Protein Kinase Inhibitor.

How it is made

The formation of the pyrrole was performed according to the classical Knorr synthesis, and hydrolysis of the tert-butylester with a subsequent decarboxylation reaction occurred smoothly with sulfuric acid in aqueous methanol at 65 °C. Thereafter, reaction with the Vilsmeier reagent (chloromethylenedimethylammonium chloride) in acetonitrile afforded the corresponding complex, which upon addition of 5-fluorooxindole and pulverized potassium hydroxide yielded the desired product.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Sunitinib is traded under.

HS 2933.79Indicative HS code

Lactams, other lactams

World exports in 2024
$16.2B
−64.4% vs 2023, imports $15.4B
2019 to 2024
Top exporters
  1. Ireland37.0%
  2. France * partner reported15.6%
  3. Spain11.3%
Top importers
  1. Germany27.8%
  2. Ireland18.9%
  3. Panama * partner reported12.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Sunitinib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Sunitinib, based on the data on this page

What is Sunitinib?

Sunitinib is a member of pyrroles and a monocarboxylic acid amide. It has a role as an antineoplastic agent, an angiogenesis inhibitor, an immunomodulator, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor, a neuroprotective agent and a vascular endothelial growth factor receptor antagonist.

What is the CAS number of Sunitinib?

The CAS registry number of Sunitinib is 557795-19-4. Other or deprecated CAS numbers: 342641-94-5.

What is the molecular formula and weight of Sunitinib?

The molecular formula of Sunitinib is C22H27FN4O2 and its molar mass is 398.48 g/mol.

What is Sunitinib used for?

Known uses and roles of Sunitinib include anticancer drugs in pharmaceuticals, biochemical and pharmacological tools in research and laboratory, angiogenesis inhibitor, antagonist, antimicrobial agent and 14 more.

Is Sunitinib hazardous?

Sunitinib carries the GHS signal word "Warning". Main hazards: suspected of damaging the unborn child, may cause damage to organs through prolonged or repeated exposure, very toxic to aquatic life. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Sunitinib?

Sunitinib is usually classified under HS code 293379 (Lactams, other lactams). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Sunitinib?

CompoundList lists 90 suppliers of Sunitinib in China, United States, India, Germany and 12 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Sunitinib in India?

5 suppliers in India list Sunitinib on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Sunitinib?

Suppliers quote Sunitinib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Sunitinib

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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